Simvastatin maintains function and viability of steatotic rat livers procured for transplantation

Journal of Hepatology

Volumn 58, Issue 6, 2013, Pages 1140-1146

  Gracia Sancho, Jordi ^a   García Calderó, Héctor ^a   Hide, Diana ^a   Marrone, Giusi ^a   Guixé Muntet, Sergi ^a   Peralta, Carmen ^b   García Pagán, Juan Carlos ^a   Abraldes, Juan G ^a   Bosch, Jaime ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

Author keywords

Endothelial dysfunction; Endothelium; Ischemia; Reperfusion; Statins

Indexed keywords

NITRIC OXIDE; SIMVASTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELL DEATH; CONTROL GROUP; CONTROLLED STUDY; CRYOPRESERVATION; DRUG EFFECT; ENDOTHELIUM; FATTY LIVER; GRAFT DYSFUNCTION; LIPID DIET; LIVER GRAFT; LIVER INJURY; LIVER PARENCHYMA; LIVER PROTECTION; LIVER TRANSPLANTATION; MALE; MICROCIRCULATION; NONHUMAN; ORGAN DONOR; OXIDATIVE STRESS; PRIORITY JOURNAL; RAT; REPERFUSION; ANIMAL; DRUG EFFECTS; LIVER; LIVER CIRCULATION; ORGAN PRESERVATION; PATHOPHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANIMALS; CRYOPRESERVATION; FATTY LIVER; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LIVER; LIVER CIRCULATION; LIVER TRANSPLANTATION; MALE; ORGAN PRESERVATION; RATS; RATS, SPRAGUE-DAWLEY; SIMVASTATIN;

EID: 84877925296     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2013.02.005     Document Type: Article

References (37)

1. J. Pirenne, F. van Gelder, R. Aerts, D. Monbaliu, D. Van Hees, and J. de Roey Abdominal transplant surgery and transplant coordination university hospitals Leuven 1997-2007: an overview Acta Chir Belg 108 2008 15 21
2. J.C. Cutrin, M.G. Perrelli, B. Cavalieri, C. Peralta, C.J. Rosell, and G. Poli Microvascular dysfunction induced by reperfusion injury and protective effect of ischemic preconditioning Free Radic Biol Med 33 2002 1200 1208
3. N. Selzner, H. Rudiger, R. Graf, and P.A. Clavien Protective strategies against ischemic injury of the liver Gastroenterology 125 2003 917 936
4. R.W. Busuttil, and K. Tanaka The utility of marginal donors in liver transplantation Liver Transpl 9 2003 651 663
5. M. Selzner, and P.A. Clavien Fatty liver in liver transplantation and surgery Semin Liver Dis 21 2001 105 113
6. J.C. Caldwell-Kenkel, R.T. Currin, Y. Tanaka, R.G. Thurman, and J.J. Lemasters Reperfusion injury to endothelial cells following cold ischemic storage of rat livers Hepatology 10 1989 292 299
7. I. Marzi, Z. Zhong, J.J. Lemasters, and R.G. Thurman Evidence that graft survival is not related to parenchymal cell viability in rat liver transplantation. The importance of nonparenchymal cells Transplantation 48 1989 463 468
8. U. Rauen, B. Polzar, H. Stephan, H.G. Mannherz, and G.H. De Cold-induced apoptosis in cultured hepatocytes and liver endothelial cells: mediation by reactive oxygen species FASEB J 13 1999 155 168
9. H. Jaeschke Molecular mechanisms of hepatic ischemia-reperfusion injury and preconditioning Am J Physiol Gastrointest Liver Physiol 284 2003 G15 G26
10. J.J. Lemasters, and R.G. Thurman Reperfusion injury after liver preservation for transplantation Annu Rev Pharmacol Toxicol 37 1997 327 338
11. J. Gracia-Sancho, G. Villarreal Jr., Y. Zhang, J.X. Yu, Y. Liu, and S.G. Tullius Flow cessation triggers endothelial dysfunction during organ cold storage conditions: strategies for pharmacologic intervention Transplantation 90 2010 142 149
12. L. Russo, J. Gracia-Sancho, H. Garcia-Caldero, G. Marrone, J.C. Garcia-Pagan, and G. Garcia-Cardena Addition of simvastatin to cold storage solution prevents endothelial dysfunction in explanted rat livers Hepatology 55 2012 921 930
13. V.T. Samuel, Z.X. Liu, X. Qu, B.D. Elder, S. Bilz, and D. Befroy Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease J Biol Chem 279 2004 32345 32353
14. M. Pasarin, J.G. Abraldes, A. Rodriguez-Vilarrupla, V. LaMura, J.C. Garcia-Pagan, and J. Bosch Insulin resistance and liver microcirculation in a rat model of early NAFLD J Hepatol 55 2011 1095 1102
15. J. Gracia-Sancho, B. Laviña, A. Rodriguez-Vilarrupla, R.P. Brandes, M. Fernandez, and J. Bosch Evidence against NADPH oxidase modulating hepatic vascular tone in cirrhosis Gastroenterology 133 2007 959 966
16. T.K. Gupta, M. Toruner, M.K. Chung, and R.J. Groszmann Endothelial dysfunction and decreased production of nitric oxide in the intrahepatic microcirculation of cirrhotic rats Hepatology 28 1998 926 931
17. J. Gracia-Sancho, L. Russo, H. Garcia-Caldero, J.C. Garcia-Pagan, G. Garcia-Cardena, and J. Bosch Endothelial expression of transcription factor Kruppel-like factor 2 and its vasoprotective target genes in the normal and cirrhotic rat liver Gut 60 2011 517 524
18. M. Pasarin, V. La Mura, J. Gracia-Sancho, H. Garcia-Caldero, A. Rodriguez-Vilarrupla, and J.C. Garcia-Pagan Sinusoidal endothelial dysfunction precedes inflammation and fibrosis in a model of NAFLD PLoS One 7 2012 e32785
19. J.G. Abraldes, A. Rodriguez-Vilarrupla, M. Graupera, C. Zafra, H. Garcia-Caldero, and J.C. Garcia-Pagan Simvastatin treatment improves liver sinusoidal endothelial dysfunction in CCl(4) cirrhotic rats J Hepatol 46 2007 1040 1046
20. A.L. Spitzer, O.B. Lao, A.A. Dick, R. Bakthavatsalam, J.B. Halldorson, and M.M. Yeh The biopsied donor liver: incorporating macrosteatosis into high-risk donor assessment Liver Transpl 16 2010 874 884
21. L. McCormack, P. Dutkowski, A.M. El-Badry, and P.A. Clavien Liver transplantation using fatty livers: always feasible? J Hepatol 54 2011 1055 1062
22. R. Franco-Gou, I.B. Mosbah, A. Serafin, H.B. Abdennebi, J. Rosello-Catafau, and C. Peralta New preservation strategies for preventing liver grafts against cold ischemia reperfusion injury J Gastroenterol Hepatol 22 2007 1120 1126
23. M.B. Jimenez-Castro, A. Casillas-Ramirez, M. Massip-Salcedo, M. Elias-Miro, A. Serafin, and A. Rimola Cyclic adenosine 3′,5′- monophosphate in rat steatotic liver transplantation Liver Transpl 17 2011 1099 1110
24. I.R. Lai, K.J. Chang, H.W. Tsai, and C.F. Chen Pharmacological preconditioning with simvastatin protects liver from ischemia-reperfusion injury by heme oxygenase-1 induction Transplantation 85 2008 732 738
25. L. Llacuna, A. Fernandez, C.V. Montfort, N. Matias, L. Martinez, and F. Caballero Targeting cholesterol at different levels in the mevalonate pathway protects fatty liver against ischemia-reperfusion injury J Hepatol 54 2011 1002 1010
26. H. Ajamieh, G. Farrell, H.J. Wong, J. Yu, E. Chu, and J. Chen Atorvastatin protects obese mice against hepatic ischemia-reperfusion injury by Toll-like receptor-4 suppression and endothelial nitric oxide synthase activation J Gastroenterol Hepatol 27 2012 1353 1361
27. J. Trebicka, M. Hennenberg, W. Laleman, N. Shelest, E. Biecker, and M. Schepke Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase Hepatology 46 2007 242 253
28. G. Marrone, L. Russo, E. Rosado, D. Hide, G. Garcia-Cardena, and J.C. Garcia-Pagan The transcription factor KLF2 mediates hepatic endothelial protection and paracrine endothelial-stellate cell deactivation induced by statins J Hepatol 58 2013 98 103
29. R. Singh, and A.M. Cuervo Autophagy in the cellular energetic balance Cell Metab 13 2011 495 504
30. J. Evankovich, R. Zhang, J.S. Cardinal, L. Zhang, J. Chen, and H. Huang Calcium/calmodulin-dependent protein kinase IV limits organ damage in hepatic ischemia-reperfusion injury through induction of autophagy Am J Physiol Gastrointest Liver Physiol 303 2012 G189 G198
31. T. Minor, J. Stegemann, A. Hirner, and M. Koetting Impaired autophagic clearance after cold preservation of fatty livers correlates with tissue necrosis upon reperfusion and is reversed by hypothermic reconditioning Liver Transpl 15 2009 798 805
32. K. Gotoh, Z. Lu, M. Morita, M. Shibata, M. Koike, and S. Waguri Participation of autophagy in the initiation of graft dysfunction after rat liver transplantation Autophagy 5 2009 351 360
33. K. Teramoto, J.L. Bowers, J.B. Kruskal, and M.E. Clouse Hepatic microcirculatory changes after reperfusion in fatty and normal liver transplantation in the rat Transplantation 56 1993 1076 1082
34. H. de Groot, and U. Rauen Ischemia-reperfusion injury: processes in pathogenetic networks: a review Transplant Proc 39 2007 481 484
35. N. Selzner, M. Selzner, W. Jochum, B. Mann-Vesti, R. Graf, and P.A. Clavien Mouse livers with macrosteatosis are more susceptible to normothermic ischemic injury than those with microsteatosis J Hepatol 44 2006 694 701
36. A. Serafin, J. Rosello-Catafau, N. Prats, C. Xaus, E. Gelpi, and C. Peralta Ischemic preconditioning increases the tolerance of fatty liver to hepatic ischemia-reperfusion injury in the rat Am J Pathol 161 2002 587 601
37. J. Gracia-Sancho Enhancing organ pool by statins: is this the future? J Gastroenterol Hepatol 27 2012 1259 1260