Pharmacological preconditioning with simvastatin protects liver from ischemia-reperfusion injury by heme oxygenase-1 induction

Transplantation

Volumn 85, Issue 5, 2008, Pages 732-738

  Lai, I Rue ^a   Chang, King Jen ^a   Tsai, Hsiu Wen ^a   Chen, Chau Fong ^b  

^a NATIONAL TAIWAN UNIVERSITY HOSPITAL   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Heme oxygenase 1; Liver; Preconditioning; Simvastatin

Indexed keywords

HEME OXYGENASE 1; PROTOPORPHYRIN ZINC; SIMVASTATIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; FEMALE; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER ISCHEMIA; LIVER PROTECTION; NICK END LABELING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REPERFUSION INJURY;

ALANINE TRANSAMINASE; ANIMALS; APOPTOSIS; ENZYME INDUCTION; FEMALE; HEME OXYGENASE-1; HEMODYNAMICS; IMMUNOHISTOCHEMISTRY; ISCHEMIC PRECONDITIONING; LIVER; RATS; RATS, WISTAR; REPERFUSION INJURY; SIMVASTATIN;

EID: 40849100144     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e3181664e70     Document Type: Article

References (31)

1. Choi AM, Alam J. Heme oxygenase-1: Function, regulation, and implication of a novel stress-inducible protein in oxidant-induced lung injury. Am J Respir Cell Mol Biol 1996; 15: 9.
2. Stocker R, Glazer AN, Ames BN. Antioxidant activity of albumin-bound bilirubin. Proc Natl Acad Sci USA 1987; 84: 5918.
3. Morita T, Perrella MA, Lee ME, Kourembanas S. Smooth muscle cell-derived carbon monoxide is a regulator of vascular cGMP. Proc Nat Acad Sci USA 1995; 92: 1475.
4. Lee PJ, Jiang BH, Chin BY, et al. Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. J Biol Chem 1997; 272: 5375.
5. Keyse SM, Tyrrel RM. Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UV radiation, hydrogen peroxide and sodium arsenite. Proc Natl Acad Sci USA 1989; 86: 99.
6. Ewing JF, Maines MD. Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: Heme oxygenase 2 is not a heat shock protein. Proc Natl Acad Sci USA 1991; 88: 5364.
7. Poss KD, Tonegawa S. Reduced stress defense in heme oxygenase 1-deficient cells. Proc Nat Acad Sci USA 1997; 94: 10925.
8. I-Rue Lai, Ming-Chieh Ma, Chau-Fong Chen, King-Jen Chang. The protective role of heme oxgenase-1 on liver after hypoxic preconditioning in rats. Transplantation 2004; 77: 1004.
9. I-Rue Lai, King-Jen Chang, Chau-Fong Chen, Hsiu-Wen Tsai. Transient limb ischemia induces remote preconditioning in liver among rats: The protective role of heme oxygenase-1. Transplantation 2006; 81: 1311.
10. Maron DJ, Fazio S, Linton MF. Current perspectives on statins. Circulation 2000; 101: 207.
11. Dichtl W, Dulak J, Frick M, et al. HMG-CoA reductase inhibitors regulate inflammatory transcription factors in human endothelial and vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2003; 23: 58.
12. Takemoto M, Liao JK. Pleiotropic effects of 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors. Arterioscler Thromb Vasc Biol 2001; 21: 1712.
13. Chandrasekar B, Mummidi S, Mahimainathan L, et al. Interleukin-18-induced human coronary artery smooth muscle cell migration is dependent on NF-kappaB and AP-1-mediated matrix metalloproteinase-9 expression and is inhibited by atorvastatin. J Biol Chem 2006; 281: 15099.
14. Lee TS, Chang CC, Zhu Y, Shyy JYJ. Simvastatin induces heme oxygenase-1: A novel mechanism of vessel protection. Circulation 2004; 110: 1296.
15. Hsu M, Muchova L, Morioka I, Wong RJ, Schroder H, Stevenson DK. Tissue-specific effects of statins on the expression of heme oxygenase-1 in vivo. Biochem Biophys Res Commumn 2006; 343: 738.
16. Asakawa H, Jeppsson B, Mack P, Hultberg B, Hagerstrand I, Bengmark S. Acute ischemic liver failure in the rat: A reproducible model not requiring portal decompression. Eur Surg Res 1989; 21: 42.
17. Iseri S, Ercan F, Gedik N, Yuksel M, Alican I. Simvastatin attenuates cisplatin-induced kidney and liver damage in rats. Toxicology 2007 12; 230: 256.
18. Nesić Z, Todorović Z, Stojanović R, et al. Single-dose intravenous simvastatin treatment attenuates renal injury in an experimental model of ischemia-reperfusion in the rat. J Pharmacol Sci 2006; 102: 413.
19. Sironi L, Cimino M, Guerrini U, et al. Treatment with statins after induction of focal ischemia in rats reduces the extent of brain damage. Arterioscler Thromb Vasc Biol 2003; 23: 322.
20. Zhu B, Shen H, Zhou J, Lin F, Hu Y. Effects of simvastatin on oxidative stress in streptozotocin-induced diabetic rats: A role for glomeruli protection. Nephron Exp Nephrol 2005; 101: e1.
21. Endres M, Laufs U, Huang Z, et al. Stroke protection by 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase inhibitors mediated by endothelial nitric oxide synthase. Proc Natl Acad Sci USA 1998; 95: 8880.
22. Sabbatini M, Pisani A, Uccello F, et al. Atorvastatin improves the course of ischemic acute renal failure in aging rats. J Am Soc Nephrol 2004; 15: 901.
23. Chen JC, Huang KC, Lin WW. HMG-CoA reductase inhibitors upregulate heme oxygenase-1 expression in murine RAW264.7 macrophages via ERK, p38 MAPK and protein kinase G pathways. Cell Signal 2006; 18: 32.
24. Uchiyama T, Atsuta H, Utsugi T, et al. Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis 2006; 188: 265.
25. -/- mice. Am J Pathol 2007; 170: 1820.
26. Ferris CD, Jaffrey SR, Sawa A, et al. Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol 1999; 1: 152.
27. Pannen BHJ, Köhler N, Hole B, Bauer M, Clemens MG, Geiger KK. Protective role of endogenous carbon monoxide in hepatic microcirculatory dysfunction after hemorrhagic shock in rats. J Clin Invest 1998; 102: 1220.
28. Sass G, Soares MC, Yamashita K, et al. Heme oxygenase-1 and its reaction product, carbon monoxide, prevent inflammation-related apoptotic liver damage in mice. Hepatology 2003; 38: 909.
29. Petrowsky H, McCormack L, Trujillo M, Selzner M, Jochum W, Clavien PA. A prospective, randomized, controlled trial comparing intermittent portal triad clamping versus ischemic preconditioning with continuous clamping for major liver resection. Ann Surg 2006; 244: 921.
30. Schmidt R, Trischler E, Hoetzel A, et al. Heme oxygenase-1 induction by the clinically used anesthetic isoflurane protects rat livers from ischemia/ reperfusion injury. Ann Surg 2007; 245: 931.
31. Lutton JD, G. Abraham NG, Drummond GS, Levere RD, Kappas A. Zinc porphyrins: Potent inhibitors of hematopoieses in animal and human bone marrow. Proc Natl Acad Sci USA 1997; 94: 1432.