Change in functional selectivity of morphine with the development of antinociceptive tolerance

British Journal of Pharmacology

Volumn 172, Issue 2, 2015, Pages 549-561

  Macey, T A ^a   Bobeck, E N ^b   Suchland, K L ^a   Morgan, M M ^b   Ingram, S L ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b WASHINGTON STATE UNIVERSITY   (United States)

Author keywords

endocytosis; ERK; functional selectivity; ligand bias; morphine; morphine tolerance; opiate; opioid; periaqueductal gray

Indexed keywords

DYNAMIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MORPHINE; MU OPIATE RECEPTOR; DERMORPHIN; NARCOTIC ANALGESIC AGENT; OPIATE PEPTIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; HOT PLATE TEST; INTERNALIZATION; MALE; MORPHINE TOLERANCE; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; RAT; SIGNAL TRANSDUCTION; VENTROLATERAL PERIAQUEDUCTAL GRAY MATTER; ANIMAL; DRUG TOLERANCE; HEAT; METABOLISM; PAIN; PHYSIOLOGY; SPRAGUE DAWLEY RAT;

ANALGESICS, OPIOID; ANIMALS; DRUG TOLERANCE; DYNAMINS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; HOT TEMPERATURE; MALE; MORPHINE; OPIOID PEPTIDES; PAIN; PERIAQUEDUCTAL GRAY; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU;

EID: 84920188510     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.12703     Document Type: Article

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