Increased agonist affinity at the μ-opioid receptor induced by prolonged agonist exposure

Journal of Neuroscience

Volumn 33, Issue 9, 2013, Pages 4118-4127

  Birdsong, William T ^a   Arttamangkul, Seksiri ^a   Clark, Mary J ^b   Cheng, Kejun ^c   Rice, Kenner C ^c   Traynor, John R ^b   Williams, John T ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ARRESTIN; CHLORNALTREXAMINE; CONCANAVALIN A; DERMORPHIN DERIVATIVE; DIPRENORPHINE; ENKEPHALIN; ENKEPHALIN [2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANINE NUCLEOTIDE BINDING PROTEIN; MU OPIATE RECEPTOR; NALOXONE; NALTREXAMINE DERIVATIVE; PERTUSSIS TOXIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING KINETICS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DOWN REGULATION;

ANALGESICS, OPIOID; ANALYSIS OF VARIANCE; ANIMALS; ARRESTIN; CELL MEMBRANE; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO, MAMMALIAN; ENKEPHALIN, ALA(2)-MEPHE(4)-GLY(5)-; FIBROBLASTS; GENE EXPRESSION; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HEK293 CELLS; HUMANS; LIGANDS; MICE; MICE, KNOCKOUT; MORPHINE; NALTREXONE; NARCOTIC ANTAGONISTS; OPIOID PEPTIDES; ORGANIC CHEMICALS; PERTUSSIS TOXIN; PHARMACOLOGICAL PHENOMENA; PROTEIN BINDING; PROTEIN CONFORMATION; RADIOLIGAND ASSAY; RECEPTORS, OPIOID, MU; SUBSTRATE SPECIFICITY; TIME FACTORS; TRANSFECTION; TRITIUM;

EID: 84874597038     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.4187-12.2013     Document Type: Article

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