Tolerance to repeated morphine administration is associated with increased potency of opioid agonists

Neuropsychopharmacology

Volumn 33, Issue 10, 2008, Pages 2494-2504

  Ingram, Susan L ^a   Macey, Tara A ^a   Fossum, Erin N ^a   Morgan, Michael M ^a  

^a WSU Vancouver ^*  (United States)

Author keywords

opioid receptors; Antinociception; Descending pain pathway; Desensitization; GIRK channels; Periaqueductal gray

Indexed keywords

1 [2 (BENZHYDRYLIDENEAMINOOXY)ETHYL] 1,2,5,6 TETRAHYDRO 3 PYRIDINECARBOXYLIC ACID; 4 AMINOBUTYRIC ACID B RECEPTOR; BACLOFEN; BENZYL[3 [[1 (3,4 DICHLOROPHENYL)ETHYL]AMINO] 2 HYDROXYPROPYL]PHOSPHINIC ACID; BETA FUNALTREXAMINE; DELTORPHIN; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; METENKEPHALIN; MORPHINE; MU OPIATE RECEPTOR; N,N DIALLYLTYROSYL 2 METHYLALANYL 2 METHYLALANYLPHENYLALANYLLEUCINE; NALOXONE; OPIATE AGONIST; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; DESENSITIZATION; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; DRUG EXPOSURE; DRUG POTENCY; DRUG TOLERANCE; MALE; NOCICEPTION; NONHUMAN; PERIAQUEDUCTAL GRAY MATTER; POTASSIUM CURRENT; PRIORITY JOURNAL; RAT;

ANALGESICS, OPIOID; ANIMALS; BRAIN CHEMISTRY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; ENKEPHALIN, METHIONINE; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; MALE; MORPHINE DEPENDENCE; NALTREXONE; NARCOTIC ANTAGONISTS; PERIAQUEDUCTAL GRAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID; RECEPTORS, OPIOID, MU;

EID: 49549106922     PISSN: 0893133X     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.npp.1301634     Document Type: Article

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