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Volumn 154, Issue 2, 2008, Pages 384-396
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Cellular neuroadaptations to chronic opioids: Tolerance, withdrawal and addiction
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Author keywords
Desensitization; Downregulation; Morphine; Neuroadaptation; Opioid; Opioid addiction; Opioid tolerance; Opioid withdrawal; Synaptic plasticity
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Indexed keywords
ADENYLATE CYCLASE;
BETA ARRESTIN 2;
CYCLIC AMP;
CYCLIC AMP DEPENDENT PROTEIN KINASE;
ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE];
ETORPHINE;
METHADONE;
MITOGEN ACTIVATED PROTEIN KINASE;
MORPHINE;
MU OPIATE RECEPTOR;
NEUROPEPTIDE;
OPIATE;
PHOSPHATIDYLINOSITOL 3 KINASE;
SUFENTANIL;
ADAPTATION;
CELLULAR NEUROADAPTATION;
CENTRAL NERVOUS SYSTEM;
COMPULSION;
DESENSITIZATION;
DNA RESPONSIVE ELEMENT;
DOWN REGULATION;
DRUG DEPENDENCE;
DRUG EXPOSURE;
DRUG TOLERANCE;
DRUG WITHDRAWAL;
GLIA CELL;
HUMAN;
INTOXICATION;
LEARNING;
LONG TERM DEPRESSION;
LONG TERM POTENTIATION;
NERVE CELL;
NERVE CELL NETWORK;
NERVE CELL PLASTICITY;
NONHUMAN;
PRIORITY JOURNAL;
PROTEIN PROTEIN INTERACTION;
REVIEW;
SIGNAL TRANSDUCTION;
SYNAPSE;
UPREGULATION;
1-PHOSPHATIDYLINOSITOL 3-KINASE;
ADAPTATION, PHYSIOLOGICAL;
ADENYLATE CYCLASE;
ANALGESICS, OPIOID;
ANIMALS;
BEHAVIOR, ADDICTIVE;
BRAIN;
CYCLIC AMP;
CYCLIC AMP-DEPENDENT PROTEIN KINASES;
DRUG TOLERANCE;
HUMANS;
MITOGEN-ACTIVATED PROTEIN KINASES;
NEURAL PATHWAYS;
NEURONAL PLASTICITY;
OPIOID-RELATED DISORDERS;
RECEPTORS, OPIOID, MU;
SIGNAL TRANSDUCTION;
SUBSTANCE WITHDRAWAL SYNDROME;
SYNAPTIC TRANSMISSION;
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EID: 43449124117
PISSN: 00071188
EISSN: 14765381
Source Type: Journal
DOI: 10.1038/bjp.2008.100 Document Type: Review |
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Times cited : (345)
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References (123)
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