Activation of ER stress and mTORC1 suppresses hepatic sortilin-1 levels in obese mice

Journal of Clinical Investigation

Volumn 122, Issue 5, 2012, Pages 1677-1687

  Ai, Ding ^a   Baez, Juan M ^a   Jiang, Hongfeng ^a   Conlon, Donna M ^a   Hernandez Ono, Antonio ^a   Frank Kamenetsky, Maria ^b   Milstein, Stuart ^b   Fitzgerald, Kevin ^b   Murphy, Andrew J ^a   Woo, Connie W ^a   Strong, Alanna ^c   Ginsberg, Henry N ^a   Tabas, Ira ^a   Rader, Daniel J ^c   Tall, Alan R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b ALNYLAM PHARMACEUTICALS   (United States)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 PHENYLBUTYRIC ACID; ACTIVATING TRANSCRIPTION FACTOR 3; APOLIPOPROTEIN B; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MESSENGER RNA; RAPAMYCIN; SORTILIN; TRIACYLGLYCEROL; TUNICAMYCIN; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; DYSLIPIDEMIA; ENDOPLASMIC RETICULUM STRESS; LIPID DIET; LIPOPROTEIN SECRETION; LIVER; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; RECEPTOR DOWN REGULATION;

ACTIVATING TRANSCRIPTION FACTOR 3; ADAPTOR PROTEINS, VESICULAR TRANSPORT; ANIMALS; ANTIGENS, CD95; APOLIPOPROTEINS B; BASE SEQUENCE; BINDING SITES; DIET, HIGH-FAT; DOWN-REGULATION; ENDOPLASMIC RETICULUM STRESS; GENE EXPRESSION REGULATION; HUMANS; LIPID METABOLISM; LIPOPROTEINS, VLDL; LIVER; MICE; MICE, INBRED C57BL; MICE, OBESE; OBESITY; PROMOTER REGIONS, GENETIC; PROTEINS; SIROLIMUS; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; TRANSCRIPTION, GENETIC; TRIGLYCERIDES;

EID: 84860593304     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI61248     Document Type: Article

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