Multiple drugs compete for transport via the Plasmodium falciparum chloroquine resistance transporter at distinct but interdependent sites

Journal of Biological Chemistry

Volumn 289, Issue 52, 2014, Pages 36336-36351

  Bellanca, Sebastiano ^a   Summers, Robert L ^b   Meyrath, Max ^a   Dave, Anurag ^a   Nash, Megan N ^c   Dittmer, Martin ^a   Sanchez, Cecilia P ^a   Stein, Wilfred D ^c   Martin, Rowena E ^c   Lanzer, Michael ^a  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY;

ANTIMALARIAL DRUG; CHLOROQUINE RESISTANCE; DETAILED KINETICS; DIFFERENT SUBSTRATES; INTERACTING SITES; MULTIDRUG RESISTANCE; PLASMODIUM FALCIPARUM; SUBSTRATE-BINDING SITES;

DRUG THERAPY;

MULTIDRUG RESISTANCE PROTEIN; PLASMODIUM FALCIPARUM CHLOROQUINE RESISTANCE TRANSPORTER; QUINIDINE; QUININE; UNCLASSIFIED DRUG; VERAPAMIL; ANTIMALARIAL AGENT; CARRIER PROTEIN; CHLOROQUINE; PFCRT PROTEIN, PLASMODIUM FALCIPARUM; PROTOZOAL PROTEIN;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG PROTEIN BINDING; DRUG TRANSPORT; FEMALE; KINETICS; MOLECULAR MECHANICS; NONHUMAN; ANIMAL; ANTAGONISTS AND INHIBITORS; BINDING COMPETITION; BINDING SITE; CELL CULTURE; DRUG RESISTANCE; METABOLISM; PH; PHYSIOLOGY; PLASMODIUM FALCIPARUM; TRANSPORT AT THE CELLULAR LEVEL; XENOPUS LAEVIS;

PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; BINDING SITES; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CHLOROQUINE; DRUG RESISTANCE; FEMALE; HYDROGEN-ION CONCENTRATION; KINETICS; MEMBRANE TRANSPORT PROTEINS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; QUINIDINE; QUININE; VERAPAMIL; XENOPUS LAEVIS;

EID: 84919936060     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.614206     Document Type: Article

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