Diverse mutational pathways converge on saturable chloroquine transport via the malaria parasite's chloroquine resistance transporter

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 17, 2014, Pages

  Summers, Robert L ^a   Dave, Anurag ^b   Dolstra, Tegan J ^a   Bellanca, Sebastiano ^b   Marchetti, Rosa V ^a   Nash, Megan N ^a   Richards, Sashika N ^a   Goh, Valerie ^a   Schenk, Robyn L ^a   Stein, Wilfred D ^c   Kirk, Kiaran ^a   Sanchez, Cecilia P ^b   Lanzer, Michael ^a   Martin, Rowena E ^a  

^a AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^b UNIVERSITY HOSPITAL HEIDELBERG   (Germany)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Drug resistance; Evolutionary biochemistry; Xenopus oocytes

Indexed keywords

CHLOROQUINE;

ANIMAL CELL; ARTICLE; DRUG TRANSPORT; HAPLOTYPE; MUTATIONAL ANALYSIS; NONHUMAN; OOCYTE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURFACE PROPERTY; XENOPUS LAEVIS;

DRUG RESISTANCE; EVOLUTIONARY BIOCHEMISTRY; XENOPUS OOCYTES;

AMINO ACID SEQUENCE; ANIMALS; BIOLOGICAL TRANSPORT; CHLOROQUINE; DRUG RESISTANCE; HAPLOTYPES; KINETICS; MALARIA, FALCIPARUM; MEMBRANE TRANSPORT PROTEINS; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; MUTATION; OOCYTES; PARASITES; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION; XENOPUS LAEVIS;

EID: 84899651699     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1322965111     Document Type: Article

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