Quinine dimers are potent inhibitors of the plasmodium falciparum chloroquine resistance transporter and are active against quinoline-resistant P. falciparum

ACS Chemical Biology

Volumn 9, Issue 3, 2014, Pages 722-730

  Hrycyna, Christine A ^a   Summers, Robert L ^b   Lehane, Adele M ^b   Pires, Marcos M ^a   Namanja, Hilda ^a   Bohn, Kelsey ^a   Kuriakose, Jerrin ^a   Ferdig, Michael ^c   Henrich, Philipp P ^d   Fidock, David A ^d   Kirk, Kiaran ^b   Chmielewski, Jean ^a   Martin, Rowena E ^b  

^a PURDUE UNIVERSITY   (United States)

^b AUSTRALIAN NATIONAL UNIVERSITY   (Australia)

^c UNIVERSITY OF NOTRE DAME   (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIMALARIAL AGENT; CARRIER PROTEINS AND BINDING PROTEINS; CHLOROQUINE; CHLOROQUINE RESISTANCE TRANSPORTER; CONCANAMYCIN A; MULTIDRUG RESISTANCE ASSOCIATED PROTEIN 1; MULTIDRUG RESISTANCE TRANSPORTER 1 PROTEIN; QUININE DERIVATIVE; QUININE DIMER; QUINOLINE; UNCLASSIFIED DRUG; VERAPAMIL; CARRIER PROTEIN; PFCRT PROTEIN, PLASMODIUM FALCIPARUM; PROTOZOAL PROTEIN; QUININE; QUINOLINE DERIVATIVE;

ALKALINIZATION; ANIMAL CELL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG SUSCEPTIBILITY; ARTICLE; CELL MEMBRANE; CELL ORGANELLE; CELL VACUOLE; CONTROLLED STUDY; CROSS RESISTANCE; DRUG STRUCTURE; HETEROLOGOUS EXPRESSION; IC 50; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; OOCYTE; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN INTERACTION; XENOPUS LAEVIS; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DIMERIZATION; DOSE RESPONSE; DRUG EFFECTS; DRUG RESISTANCE; DRUG STABILITY; GENETIC TRANSFECTION; GENETICS; MALARIA; METABOLISM; MOUSE; PARASITOLOGY; PLASMODIUM BERGHEI;

ANIMALS; ANTIMALARIALS; DIMERIZATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG RESISTANCE; DRUG STABILITY; MALARIA; MEMBRANE TRANSPORT PROTEINS; MICE; MOLECULAR STRUCTURE; OOCYTES; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; QUININE; QUINOLINES; TRANSFECTION; XENOPUS LAEVIS;

EID: 84896949152     PISSN: 15548929     EISSN: 15548937     Source Type: Journal    
DOI: 10.1021/cb4008953     Document Type: Article

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