Understanding polyspecificity within the substrate-binding cavity of the human multidrug resistance P-glycoprotein

FEBS Journal

Volumn 281, Issue 3, 2014, Pages 673-682

  Martinez, Lorena ^a   Arnaud, Ophélie ^a   Henin, Emilie ^b   Tao, Houchao ^c   Chaptal, Vincent ^a   Doshi, Rupak ^d   Andrieu, Thibault ^e   Dussurgey, Sébastien ^e   Tod, Michel ^b   Di Pietro, Attilio ^a   Zhang, Qinghai ^c   Chang, Geoffrey ^d   Falson, Pierre ^a  

^a UNIVERSITÉ LYON 1   (France)

^b UNIVERSITÉ CLAUDE BERNARD LYON 1   (France)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e INSERM   (France)

Author keywords

ABC transporters; Cancer; Drug efflux; Drug resistance; Drug binding sites; P glycoprotein

Indexed keywords

DAUNORUBICIN; HEXAPEPTIDE; HOE 33342; MULTIDRUG RESISTANCE PROTEIN;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG TRANSPORT; ENANTIOMER; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; PRIORITY JOURNAL;

CITRUS MAXIMA;

ABC TRANSPORTERS; CANCER; DRUG EFFLUX; DRUG RESISTANCE; DRUG-BINDING SITES; P-GLYCOPROTEIN;

ANIMALS; ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; BINDING, COMPETITIVE; BIOLOGICAL TRANSPORT; CATALYTIC DOMAIN; DAUNORUBICIN; DRUG RESISTANCE, MULTIPLE; HUMANS; KINETICS; MEMBRANE TRANSPORT MODULATORS; MICE; MODELS, MOLECULAR; MOLECULAR DOCKING SIMULATION; NIH 3T3 CELLS; P-GLYCOPROTEIN; PEPTIDES, CYCLIC; PROTEIN ISOFORMS; RECOMBINANT PROTEINS; STEREOISOMERISM;

EID: 84897061254     PISSN: 1742464X     EISSN: 17424658     Source Type: Journal    
DOI: 10.1111/febs.12613     Document Type: Article

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