A transcriptomics-based hepatotoxicity comparison between the zebrafish embryo and established human and rodent in vitro and in vivo models using cyclosporine A, amiodarone and acetaminophen

Toxicology Letters

Volumn 232, Issue 2, 2015, Pages 403-412

  Driessen, Marja ^a,b   Vitins, Alexa P ^a,c   Pennings, Jeroen L A ^a   Kienhuis, Anne S ^a   Water, Bob van de ^b   van der Ven, Leo T M ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

^c MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Gene expression; Hepatotoxicity; Human in vitro; Mouse in vitro; Mouse in vivo; Rat in vitro; Rat in vivo; Zebrafish embryo

Indexed keywords

AMIODARONE; BILE ACID; CYCLOSPORIN A; GLUCOSE; LIPID; PARACETAMOL; ANALGESIC AGENT; ANTIARRHYTHMIC AGENT; CYCLOSPORIN; IMMUNOSUPPRESSIVE AGENT; TRANSCRIPTOME;

ADULT; ANIMAL CELL; ANIMAL EMBRYO; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; EMBRYO; GENE EXPRESSION; GLUCOSE METABOLISM; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIPID METABOLISM; LIVER CELL; LIVER TOXICITY; MALE; METABOLIC REGULATION; MOUSE; NONHUMAN; RAT; TRANSCRIPTOMICS; ZEBRA FISH; ZEBRAFISH EMBRYO; ANIMAL; C57BL MOUSE; COMPARATIVE STUDY; DRUG EFFECTS; PATHOLOGY; PHYSIOLOGY; TOXIC HEPATITIS;

DANIO RERIO; RATTUS; RODENTIA;

ACETAMINOPHEN; AMIODARONE; ANALGESICS, NON-NARCOTIC; ANIMALS; ANTI-ARRHYTHMIA AGENTS; CYCLOSPORINE; DRUG-INDUCED LIVER INJURY; EMBRYO, NONMAMMALIAN; GENE EXPRESSION; HEPATOCYTES; HUMANS; IMMUNOSUPPRESSIVE AGENTS; IN VITRO TECHNIQUES; MICE; MICE, INBRED C57BL; RATS; TRANSCRIPTOME; ZEBRAFISH;

EID: 84919808056     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2014.11.020     Document Type: Article

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