An in vitro assay to assess transporter-based cholestatic hepatotoxicity using sandwich-cultured rat hepatocytes

Drug Metabolism and Disposition

Volumn 38, Issue 2, 2010, Pages 276-280

  Ansede, John H ^a   Smith, William R ^a   Perry, Cassandra H ^a   St Claire III, Robert L ^a   Brouwer, Kenneth R ^a  

^a Qualyst Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILE ACID; BOSENTAN; CYCLOSPORIN A; ERYTHROMYCIN ESTOLATE; GLIBENCLAMIDE; NEFAZODONE; RADIOISOTOPE; TAUROCHOLIC ACID D 8; TROGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL MODEL; ARTICLE; ASSAY; BILE ACID BLOOD LEVEL; BILIARY EXCRETION; CELL CULTURE; CONTROLLED STUDY; DRUG ACCUMULATION; DRUG CLEARANCE; DRUG DISPOSITION; DRUG UPTAKE; IN VITRO STUDY; INFORMATION; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; TANDEM MASS SPECTROMETRY;

ALGORITHMS; ANIMALS; BILE; BILE ACIDS AND SALTS; BIOLOGICAL TRANSPORT; CELLS, CULTURED; CHOLESTASIS, INTRAHEPATIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; COLLAGEN; CULTURE TECHNIQUES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG COMBINATIONS; DRUG TOXICITY; DRUG-INDUCED LIVER INJURY; HEPATOCYTES; LAMININ; MALE; PROTEOGLYCANS; RATS; RATS, WISTAR; TANDEM MASS SPECTROMETRY; TAUROCHOLIC ACID; TOXICITY TESTS;

RATTUS;

EID: 76149092167     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.109.028407     Document Type: Article

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