Mechanisms of amiodarone and valproic acid induced liver steatosis in mouse in vivo act as a template for other hepatotoxicity models

Archives of Toxicology

Volumn 88, Issue 8, 2014, Pages 1573-1588

  Vitins, Alexa P ^a,b   Kienhuis, Anne S ^a,b,c   Speksnijder, Ewoud N ^d   Roodbergen, Marianne ^a,e   Luijten, Mirjam ^a,d   Van Der Ven, Leo T M ^a,b  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b MAASTRICHT UNIVERSITY   (Netherlands)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^e LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Hepatotoxicity; In vitro models; Mouse in vivo; Steatosis; Toxicogenomics

Indexed keywords

ALANINE AMINOTRANSFERASE; AMIODARONE; ANDROGEN RECEPTOR; ASPARTATE AMINOTRANSFERASE; BIOLOGICAL MARKER; CELL NUCLEUS RECEPTOR; CHOLESTEROL; HEPATOCYTE NUCLEAR FACTOR 4ALPHA; HIGH DENSITY LIPOPROTEIN; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PREGNANE X RECEPTOR; RETINOID X RECEPTOR ALPHA; RETINOL; TETRACYCLINE; TRIACYLGLYCEROL; VALPROIC ACID; CELL RECEPTOR; TRANSCRIPTOME;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BINDING SITE; CHOLESTEROL BLOOD LEVEL; CLINICAL CHEMISTRY; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG MEGADOSE; DRUG METABOLISM; FATTY LIVER; GENE CONTROL; GENE EXPRESSION; HISTOPATHOLOGY; IN VIVO STUDY; LIPID LIVER LEVEL; LIPID STORAGE; LIPOPROTEIN BLOOD LEVEL; LIVER CELL; LOW DRUG DOSE; MALE; MOUSE; MOUSE MODEL; NONHUMAN; NUCLEOTIDE SEQUENCE; OVERLAPPING GENE; OXIDATION REDUCTION REACTION; PHENOTYPE; PRIORITY JOURNAL; RAT; RECEPTOR BINDING; SPECIES COMPARISON; TOXIC HEPATITIS; TRIACYLGLYCEROL BLOOD LEVEL; ANIMAL; C57BL MOUSE; CELL LINE; CHEMICALLY INDUCED; COMPLICATION; DISEASE MODEL; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; GENETICS; HUMAN; LIVER FUNCTION TEST; METABOLISM; PATHOLOGY; SPECIES DIFFERENCE;

RATTUS;

AMIODARONE; ANIMALS; BINDING SITES; CELL LINE; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; FATTY LIVER; HEPATOCYTES; HUMANS; LIVER FUNCTION TESTS; MALE; MICE, INBRED C57BL; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; SPECIES SPECIFICITY; TRANSCRIPTOME; VALPROIC ACID;

EID: 84904974110     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-014-1211-0     Document Type: Article

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