-
2
-
-
11244269445
-
The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle
-
Aylon Y, Liefshitz B, Kupiec M, (2004) The CDK regulates repair of double-strand breaks by homologous recombination during the cell cycle. EMBO J 23: 4868-4875
-
(2004)
EMBO J
, vol.23
, pp. 4868-4875
-
-
Aylon, Y.1
Liefshitz, B.2
Kupiec, M.3
-
3
-
-
67649881097
-
The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry
-
Ayoub N, Rajendra E, Su X, Jeyasekharan AD, Mahen R, Venkitaraman AR, (2009) The carboxyl terminus of Brca2 links the disassembly of Rad51 complexes to mitotic entry. Curr Biol 19: 1075-1085
-
(2009)
Curr Biol
, vol.19
, pp. 1075-1085
-
-
Ayoub, N.1
Rajendra, E.2
Su, X.3
Jeyasekharan, A.D.4
Mahen, R.5
Venkitaraman, A.R.6
-
4
-
-
47549098471
-
The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint
-
Bassermann F, Frescas D, Guardavaccaro D, Busino L, Peschiaroli A, Pagano M, (2008) The Cdc14B-Cdh1-Plk1 axis controls the G2 DNA-damage-response checkpoint. Cell 134: 256-267
-
(2008)
Cell
, vol.134
, pp. 256-267
-
-
Bassermann, F.1
Frescas, D.2
Guardavaccaro, D.3
Busino, L.4
Peschiaroli, A.5
Pagano, M.6
-
5
-
-
33646117239
-
Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks
-
Bekker-Jensen S, Lukas C, Kitagawa R, Melander F, Kastan MB, Bartek J, Lukas J, (2006) Spatial organization of the mammalian genome surveillance machinery in response to DNA strand breaks. J Cell Biol 173: 195-206
-
(2006)
J Cell Biol
, vol.173
, pp. 195-206
-
-
Bekker-Jensen, S.1
Lukas, C.2
Kitagawa, R.3
Melander, F.4
Kastan, M.B.5
Bartek, J.6
Lukas, J.7
-
6
-
-
46249131123
-
Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair
-
Bennardo N, Cheng A, Huang N, Stark JM, (2008) Alternative-NHEJ is a mechanistically distinct pathway of mammalian chromosome break repair. PLoS Genet 4: e1000110
-
(2008)
PLoS Genet
, vol.4
, pp. e1000110
-
-
Bennardo, N.1
Cheng, A.2
Huang, N.3
Stark, J.M.4
-
7
-
-
0023655815
-
Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis
-
Bonneau AM, Sonenberg N, (1987) Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis. J Biol Chem 262: 11134-11139
-
(1987)
J Biol Chem
, vol.262
, pp. 11134-11139
-
-
Bonneau, A.M.1
Sonenberg, N.2
-
8
-
-
17244375049
-
Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase
-
Bryant HE, Schultz N, Thomas HD, Parker KM, Flower D, Lopez E, Kyle S, Meuth M, Curtin NJ, Helleday T, (2005) Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature 434: 913-917
-
(2005)
Nature
, vol.434
, pp. 913-917
-
-
Bryant, H.E.1
Schultz, N.2
Thomas, H.D.3
Parker, K.M.4
Flower, D.5
Lopez, E.6
Kyle, S.7
Meuth, M.8
Curtin, N.J.9
Helleday, T.10
-
9
-
-
34547192058
-
BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges
-
Chan K-L, North PS, Hickson ID, (2007) BLM is required for faithful chromosome segregation and its localization defines a class of ultrafine anaphase bridges. EMBO J 26: 3397-3409
-
(2007)
EMBO J
, vol.26
, pp. 3397-3409
-
-
Chan, K.-L.1
North, P.S.2
Hickson, I.D.3
-
10
-
-
84865364870
-
Playing the end game: DNA double-strand break repair pathway choice
-
Chapman JR, Taylor MRG, Boulton SJ, (2012) Playing the end game: DNA double-strand break repair pathway choice. Mol Cell 47: 497-510
-
(2012)
Mol Cell
, vol.47
, pp. 497-510
-
-
Chapman, J.R.1
Taylor, M.R.G.2
Boulton, S.J.3
-
11
-
-
84903464777
-
Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin
-
Choi BH, Pagano M, Huang C, Dai W, (2014) Cdh1, a substrate-recruiting component of anaphase-promoting complex/cyclosome (APC/C) ubiquitin E3 ligase, specifically interacts with phosphatase and tensin homolog (PTEN) and promotes its removal from chromatin. J Biol Chem 289: 17951-17959
-
(2014)
J Biol Chem
, vol.289
, pp. 17951-17959
-
-
Choi, B.H.1
Pagano, M.2
Huang, C.3
Dai, W.4
-
12
-
-
0036578644
-
GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways
-
Dahlquist KD, Salomonis N, Vranizan K, Lawlor SC, Conklin BR, (2002) GenMAPP, a new tool for viewing and analyzing microarray data on biological pathways. Nat Genet 31: 19-20
-
(2002)
Nat Genet
, vol.31
, pp. 19-20
-
-
Dahlquist, K.D.1
Salomonis, N.2
Vranizan, K.3
Lawlor, S.C.4
Conklin, B.R.5
-
13
-
-
84890146832
-
APC/C-Cdh1 coordinates neurogenesis and cortical size during development
-
Delgado-Esteban M, García-Higuera I, Maestre C, Moreno S, Almeida A, (2013) APC/C-Cdh1 coordinates neurogenesis and cortical size during development. Nat Commun 4: 2879
-
(2013)
Nat Commun
, vol.4
, pp. 2879
-
-
Delgado-Esteban, M.1
García-Higuera, I.2
Maestre, C.3
Moreno, S.4
Almeida, A.5
-
14
-
-
84890183187
-
The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors
-
Eguren M, Porlan E, Manchado E, García-Higuera I, Cañamero M, Fariñas I, Malumbres M, (2013) The APC/C cofactor Cdh1 prevents replicative stress and p53-dependent cell death in neural progenitors. Nat Commun 4: 2880
-
(2013)
Nat Commun
, vol.4
, pp. 2880
-
-
Eguren, M.1
Porlan, E.2
Manchado, E.3
García-Higuera, I.4
Cañamero, M.5
Fariñas, I.6
Malumbres, M.7
-
15
-
-
84896701573
-
A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens
-
Eguren M, Álvarez-Fernández M, García F, Lõpez-Contreras AJ, Fujimitsu K, Yaguchi H, Luque-García JL, Fernandez-Capetillo O, Muñoz J, Yamano H, Malumbres M, (2014) A synthetic lethal interaction between APC/C and topoisomerase poisons uncovered by proteomic screens. Cell Rep 6: 670-683
-
(2014)
Cell Rep
, vol.6
, pp. 670-683
-
-
Eguren, M.1
Álvarez-Fernández, M.2
García, F.3
Lõpez-Contreras, A.J.4
Fujimitsu, K.5
Yaguchi, H.6
Luque-García, J.L.7
Fernandez-Capetillo, O.8
Muñoz, J.9
Yamano, H.10
Malumbres, M.11
-
16
-
-
78649460650
-
DNA end resection by CtIP and exonuclease 1 prevents genomic instability
-
Eid W, Steger M, El-Shemerly M, Ferretti LP, Peña-Diaz J, König C, Valtorta E, Sartori AA, Ferrari S, (2010) DNA end resection by CtIP and exonuclease 1 prevents genomic instability. EMBO Rep 11: 962-968
-
(2010)
EMBO Rep
, vol.11
, pp. 962-968
-
-
Eid, W.1
Steger, M.2
El-Shemerly, M.3
Ferretti, L.P.4
Peña-Diaz, J.5
König, C.6
Valtorta, E.7
Sartori, A.A.8
Ferrari, S.9
-
17
-
-
18144381942
-
Degradation of human exonuclease 1b upon DNA synthesis inhibition
-
El-Shemerly M, Janscak P, Hess D, Jiricny J, Ferrari S, (2005) Degradation of human exonuclease 1b upon DNA synthesis inhibition. Cancer Res 65: 3604-3609
-
(2005)
Cancer Res
, vol.65
, pp. 3604-3609
-
-
El-Shemerly, M.1
Janscak, P.2
Hess, D.3
Jiricny, J.4
Ferrari, S.5
-
18
-
-
79959968319
-
Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate
-
Emanuele MJ, Ciccia A, Elia AEH, Elledge SJ, (2011) Proliferating cell nuclear antigen (PCNA)-associated KIAA0101/PAF15 protein is a cell cycle-regulated anaphase-promoting complex/cyclosome substrate. Proc Natl Acad Sci USA 108: 9845-9850
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 9845-9850
-
-
Emanuele, M.J.1
Ciccia, A.2
Elia, A.E.H.3
Elledge, S.J.4
-
19
-
-
38949099707
-
The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells
-
Engelbert D, Schnerch D, Baumgarten A, Wäsch R, (2008) The ubiquitin ligase APC(Cdh1) is required to maintain genome integrity in primary human cells. Oncogene 27: 907-917
-
(2008)
Oncogene
, vol.27
, pp. 907-917
-
-
Engelbert, D.1
Schnerch, D.2
Baumgarten, A.3
Wäsch, R.4
-
20
-
-
15844373362
-
CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair
-
Esashi F, Christ N, Gannon J, Liu Y, Hunt T, Jasin M, West SC, (2005) CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair. Nature 434: 598-604
-
(2005)
Nature
, vol.434
, pp. 598-604
-
-
Esashi, F.1
Christ, N.2
Gannon, J.3
Liu, Y.4
Hunt, T.5
Jasin, M.6
West, S.C.7
-
21
-
-
84861843272
-
CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination
-
Falck J, Forment JV, Coates J, Mistrik M, Lukas J, Bartek J, Jackson SP, (2012) CDK targeting of NBS1 promotes DNA-end resection, replication restart and homologous recombination. EMBO Rep 13: 561-568
-
(2012)
EMBO Rep
, vol.13
, pp. 561-568
-
-
Falck, J.1
Forment, J.V.2
Coates, J.3
Mistrik, M.4
Lukas, J.5
Bartek, J.6
Jackson, S.P.7
-
22
-
-
17244373777
-
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
-
Farmer H, McCabe N, Lord CJ, Tutt ANJ, Johnson DA, Richardson TB, Santarosa M, Dillon KJ, Hickson I, Knights C, Martin NMB, Jackson SP, Smith GCM, Ashworth A, (2005) Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature 434: 917-921
-
(2005)
Nature
, vol.434
, pp. 917-921
-
-
Farmer, H.1
McCabe, N.2
Lord, C.J.3
Tutt, A.N.J.4
Johnson, D.A.5
Richardson, T.B.6
Santarosa, M.7
Dillon, K.J.8
Hickson, I.9
Knights, C.10
Martin, N.M.B.11
Jackson, S.P.12
Smith, G.C.M.13
Ashworth, A.14
-
23
-
-
4444339506
-
Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle
-
Ferreira MG, Cooper JP, (2004) Two modes of DNA double-strand break repair are reciprocally regulated through the fission yeast cell cycle. Genes Dev 18: 2249-2254
-
(2004)
Genes Dev
, vol.18
, pp. 2249-2254
-
-
Ferreira, M.G.1
Cooper, J.P.2
-
25
-
-
32544442886
-
Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines
-
French JD, Dunn J, Smart CE, Manning N, Brown MA, (2006) Disruption of BRCA1 function results in telomere lengthening and increased anaphase bridge formation in immortalized cell lines. Genes Chromosom Cancer 45: 277-289
-
(2006)
Genes Chromosom Cancer
, vol.45
, pp. 277-289
-
-
French, J.D.1
Dunn, J.2
Smart, C.E.3
Manning, N.4
Brown, M.A.5
-
26
-
-
46449095540
-
Genomic stability and tumour suppression by the APC/C cofactor Cdh1
-
García-Higuera I, Manchado E, Dubus P, Cañamero M, Méndez J, Moreno S, Malumbres M, (2008) Genomic stability and tumour suppression by the APC/C cofactor Cdh1. Nat Cell Biol 10: 802-811
-
(2008)
Nat Cell Biol
, vol.10
, pp. 802-811
-
-
García-Higuera, I.1
Manchado, E.2
Dubus, P.3
Cañamero, M.4
Méndez, J.5
Moreno, S.6
Malumbres, M.7
-
27
-
-
0029845485
-
Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells
-
Gudas JM, Li T, Nguyen H, Jensen D, Rauscher FJ, Cowan KH, (1996) Cell cycle regulation of BRCA1 messenger RNA in human breast epithelial cells. Cell Growth Differ 7: 717-723
-
(1996)
Cell Growth Differ
, vol.7
, pp. 717-723
-
-
Gudas, J.M.1
Li, T.2
Nguyen, H.3
Jensen, D.4
Rauscher, F.J.5
Cowan, K.H.6
-
28
-
-
84878881252
-
Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex
-
He J, Chao WCH, Zhang Z, Yang J, Cronin N, Barford D, (2013) Insights into degron recognition by APC/C coactivators from the structure of an Acm1-Cdh1 complex. Mol Cell 50: 649-660
-
(2013)
Mol Cell
, vol.50
, pp. 649-660
-
-
He, J.1
Chao, W.C.H.2
Zhang, Z.3
Yang, J.4
Cronin, N.5
Barford, D.6
-
29
-
-
33745265628
-
Cyclin-dependent kinase directly regulates initiation of meiotic recombination
-
Henderson KA, Kee K, Maleki S, Santini PA, Keeney S, (2006) Cyclin-dependent kinase directly regulates initiation of meiotic recombination. Cell 125: 1321-1332
-
(2006)
Cell
, vol.125
, pp. 1321-1332
-
-
Henderson, K.A.1
Kee, K.2
Maleki, S.3
Santini, P.A.4
Keeney, S.5
-
30
-
-
66149114020
-
Human CtIP mediates cell cycle control of DNA end resection and double strand break repair
-
Huertas P, Jackson SP, (2009) Human CtIP mediates cell cycle control of DNA end resection and double strand break repair. J Biol Chem 284: 9558-9565
-
(2009)
J Biol Chem
, vol.284
, pp. 9558-9565
-
-
Huertas, P.1
Jackson, S.P.2
-
31
-
-
7244220162
-
DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1
-
Ira G, Pellicioli A, Balijja A, Wang X, Fiorani S, Carotenuto W, Liberi G, Bressan D, Wan L, Hollingsworth NM, Haber JE, Foiani M, (2004) DNA end resection, homologous recombination and DNA damage checkpoint activation require CDK1. Nature 431: 1011-1017
-
(2004)
Nature
, vol.431
, pp. 1011-1017
-
-
Ira, G.1
Pellicioli, A.2
Balijja, A.3
Wang, X.4
Fiorani, S.5
Carotenuto, W.6
Liberi, G.7
Bressan, D.8
Wan, L.9
Hollingsworth, N.M.10
Haber, J.E.11
Foiani, M.12
-
32
-
-
70350504453
-
The DNA-damage response in human biology and disease
-
Jackson SP, Bartek J, (2009) The DNA-damage response in human biology and disease. Nature 461: 1071-1078
-
(2009)
Nature
, vol.461
, pp. 1071-1078
-
-
Jackson, S.P.1
Bartek, J.2
-
33
-
-
30344463835
-
ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks
-
Jazayeri A, Falck J, Lukas C, Bartek J, Smith GCM, Lukas J, Jackson SP, (2006) ATM- and cell cycle-dependent regulation of ATR in response to DNA double-strand breaks. Nat Cell Biol 8: 37-45
-
(2006)
Nat Cell Biol
, vol.8
, pp. 37-45
-
-
Jazayeri, A.1
Falck, J.2
Lukas, C.3
Bartek, J.4
Smith, G.C.M.5
Lukas, J.6
Jackson, S.P.7
-
34
-
-
79960150694
-
Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition
-
Johnson N, Li Y-C, Walton ZE, Cheng KA, Li D, Rodig SJ, Moreau LA, Unitt C, Bronson RT, Thomas HD, Newell DR, D'Andrea AD, Curtin NJ, Wong K-K, Shapiro GI, (2011) Compromised CDK1 activity sensitizes BRCA-proficient cancers to PARP inhibition. Nat Med 17: 875-882
-
(2011)
Nat Med
, vol.17
, pp. 875-882
-
-
Johnson, N.1
Li, Y.-C.2
Walton, Z.E.3
Cheng, K.A.4
Li, D.5
Rodig, S.J.6
Moreau, L.A.7
Unitt, C.8
Bronson, R.T.9
Thomas, H.D.10
Newell, D.R.11
D'Andrea, A.D.12
Curtin, N.J.13
Wong, K.-K.14
Shapiro, G.I.15
-
35
-
-
77956550868
-
Human SIRT6 promotes DNA end resection through CtIP deacetylation
-
Kaidi A, Weinert BT, Choudhary C, Jackson SP, (2010) Human SIRT6 promotes DNA end resection through CtIP deacetylation. Science 329: 1348-1353
-
(2010)
Science
, vol.329
, pp. 1348-1353
-
-
Kaidi, A.1
Weinert, B.T.2
Choudhary, C.3
Jackson, S.P.4
-
36
-
-
0030695339
-
Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein
-
Kamitani T, Kito K, Nguyen HP, Yeh ET, (1997) Characterization of NEDD8, a developmentally down-regulated ubiquitin-like protein. J Biol Chem 272: 28557-28562
-
(1997)
J Biol Chem
, vol.272
, pp. 28557-28562
-
-
Kamitani, T.1
Kito, K.2
Nguyen, H.P.3
Yeh, E.T.4
-
37
-
-
84858983547
-
KEGG for integration and interpretation of large-scale molecular data sets
-
Kanehisa M, Goto S, Sato Y, Furumichi M, Tanabe M, (2012) KEGG for integration and interpretation of large-scale molecular data sets. Nucleic Acids Res 40: D109-D114
-
(2012)
Nucleic Acids Res
, vol.40
, pp. D109-D114
-
-
Kanehisa, M.1
Goto, S.2
Sato, Y.3
Furumichi, M.4
Tanabe, M.5
-
38
-
-
84863742395
-
CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation
-
Kousholt AN, Fugger K, Hoffmann S, Larsen BD, Menzel T, Sartori AA, Sørensen CS, (2012) CtIP-dependent DNA resection is required for DNA damage checkpoint maintenance but not initiation. J Cell Biol 197: 869-876
-
(2012)
J Cell Biol
, vol.197
, pp. 869-876
-
-
Kousholt, A.N.1
Fugger, K.2
Hoffmann, S.3
Larsen, B.D.4
Menzel, T.5
Sartori, A.A.6
Sørensen, C.S.7
-
39
-
-
0034025648
-
Mitotic regulation of the APC activator proteins CDC20 and CDH1
-
Kramer ER, Scheuringer N, Podtelejnikov AV, Mann M, Peters JM, (2000) Mitotic regulation of the APC activator proteins CDC20 and CDH1. Mol Biol Cell 11: 1555-1569
-
(2000)
Mol Biol Cell
, vol.11
, pp. 1555-1569
-
-
Kramer, E.R.1
Scheuringer, N.2
Podtelejnikov, A.V.3
Mann, M.4
Peters, J.M.5
-
40
-
-
84894274928
-
RIF1: A novel regulatory factor for DNA replication and DNA damage response signaling
-
Kumar R, Cheok CF, (2014) RIF1: a novel regulatory factor for DNA replication and DNA damage response signaling. DNA Repair 15: 54-59
-
(2014)
DNA Repair
, vol.15
, pp. 54-59
-
-
Kumar, R.1
Cheok, C.F.2
-
41
-
-
80051772864
-
The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation
-
Laulier C, Cheng A, Stark JM, (2011) The relative efficiency of homology-directed repair has distinct effects on proper anaphase chromosome separation. Nucleic Acids Res 39: 5935-5944
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 5935-5944
-
-
Laulier, C.1
Cheng, A.2
Stark, J.M.3
-
42
-
-
77953229115
-
The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway
-
Lieber MR, (2010) The mechanism of double-strand DNA break repair by the nonhomologous DNA end-joining pathway. Annu Rev Biochem 79: 181-211
-
(2010)
Annu Rev Biochem
, vol.79
, pp. 181-211
-
-
Lieber, M.R.1
-
43
-
-
1642458099
-
Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells
-
Lindon C, Pines J, (2004) Ordered proteolysis in anaphase inactivates Plk1 to contribute to proper mitotic exit in human cells. J Cell Biol 164: 233-241
-
(2004)
J Cell Biol
, vol.164
, pp. 233-241
-
-
Lindon, C.1
Pines, J.2
-
44
-
-
0036714512
-
Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit
-
Littlepage LE, Ruderman JV, (2002) Identification of a new APC/C recognition domain, the A box, which is required for the Cdh1-dependent destruction of the kinase Aurora-A during mitotic exit. Genes Dev 16: 2274-2285
-
(2002)
Genes Dev
, vol.16
, pp. 2274-2285
-
-
Littlepage, L.E.1
Ruderman, J.V.2
-
45
-
-
84859078891
-
GPS-ARM: Computational analysis of the APC/C recognition motif by predicting D-boxes and KEN-boxes
-
Liu Z, Yuan F, Ren J, Cao J, Zhou Y, Yang Q, Xue Y, (2012) GPS-ARM: computational analysis of the APC/C recognition motif by predicting D-boxes and KEN-boxes. PLoS ONE 7: e34370
-
(2012)
PLoS ONE
, vol.7
, pp. e34370
-
-
Liu, Z.1
Yuan, F.2
Ren, J.3
Cao, J.4
Zhou, Y.5
Yang, Q.6
Xue, Y.7
-
46
-
-
0033592688
-
Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex
-
Lukas C, Sørensen CS, Kramer E, Santoni-Rugiu E, Lindeneg C, Peters JM, Bartek J, Lukas J, (1999) Accumulation of cyclin B1 requires E2F and cyclin-A-dependent rearrangement of the anaphase-promoting complex. Nature 401: 815-818
-
(1999)
Nature
, vol.401
, pp. 815-818
-
-
Lukas, C.1
Sørensen, C.S.2
Kramer, E.3
Santoni-Rugiu, E.4
Lindeneg, C.5
Peters, J.M.6
Bartek, J.7
Lukas, J.8
-
47
-
-
0037341599
-
Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage
-
Lukas C, Falck J, Bartkova J, Bartek J, Lukas J, (2003) Distinct spatiotemporal dynamics of mammalian checkpoint regulators induced by DNA damage. Nat Cell Biol 5: 255-260
-
(2003)
Nat Cell Biol
, vol.5
, pp. 255-260
-
-
Lukas, C.1
Falck, J.2
Bartkova, J.3
Bartek, J.4
Lukas, J.5
-
48
-
-
80455145246
-
The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks
-
Meerang M, Ritz D, Paliwal S, Garajova Z, Bosshard M, Mailand N, Janscak P, Hübscher U, Meyer H, Ramadan K, (2011) The ubiquitin-selective segregase VCP/p97 orchestrates the response to DNA double-strand breaks. Nat Cell Biol 13: 1376-1382
-
(2011)
Nat Cell Biol
, vol.13
, pp. 1376-1382
-
-
Meerang, M.1
Ritz, D.2
Paliwal, S.3
Garajova, Z.4
Bosshard, M.5
Mailand, N.6
Janscak, P.7
Hübscher, U.8
Meyer, H.9
Ramadan, K.10
-
49
-
-
33748279259
-
Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor
-
Miller JJ, Summers MK, Hansen DV, Nachury MV, Lehman NL, Loktev A, Jackson PK, (2006) Emi1 stably binds and inhibits the anaphase-promoting complex/cyclosome as a pseudosubstrate inhibitor. Genes Dev 20: 2410-2420
-
(2006)
Genes Dev
, vol.20
, pp. 2410-2420
-
-
Miller, J.J.1
Summers, M.K.2
Hansen, D.V.3
Nachury, M.V.4
Lehman, N.L.5
Loktev, A.6
Jackson, P.K.7
-
50
-
-
77952376111
-
Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair
-
Mocciaro A, Berdougo E, Zeng K, Black E, Vagnarelli P, Earnshaw W, Gillespie D, Jallepalli P, Schiebel E, (2010) Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair. J Cell Biol 189: 631-639
-
(2010)
J Cell Biol
, vol.189
, pp. 631-639
-
-
Mocciaro, A.1
Berdougo, E.2
Zeng, K.3
Black, E.4
Vagnarelli, P.5
Earnshaw, W.6
Gillespie, D.7
Jallepalli, P.8
Schiebel, E.9
-
51
-
-
0037458031
-
Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics
-
Mootha VK, Lepage P, Miller K, Bunkenborg J, Reich M, Hjerrild M, Delmonte T, Villeneuve A, Sladek R, Xu F, Mitchell GA, Morin C, Mann M, Hudson TJ, Robinson B, Rioux JD, Lander ES, (2003) Identification of a gene causing human cytochrome c oxidase deficiency by integrative genomics. Proc Natl Acad Sci USA 100: 605-610
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 605-610
-
-
Mootha, V.K.1
Lepage, P.2
Miller, K.3
Bunkenborg, J.4
Reich, M.5
Hjerrild, M.6
Delmonte, T.7
Villeneuve, A.8
Sladek, R.9
Xu, F.10
Mitchell, G.A.11
Morin, C.12
Mann, M.13
Hudson, T.J.14
Robinson, B.15
Rioux, J.D.16
Lander, E.S.17
-
52
-
-
20344405716
-
Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: Identification of an aneuploidy-promoting property
-
Nguyen HG, Chinnappan D, Urano T, Ravid K, (2005) Mechanism of Aurora-B degradation and its dependency on intact KEN and A-boxes: identification of an aneuploidy-promoting property. Mol Cell Biol 25: 4977-4992
-
(2005)
Mol Cell Biol
, vol.25
, pp. 4977-4992
-
-
Nguyen, H.G.1
Chinnappan, D.2
Urano, T.3
Ravid, K.4
-
53
-
-
0036583926
-
Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics
-
Ong S-E, Blagoev B, Kratchmarova I, Kristensen DB, Steen H, Pandey A, Mann M, (2002) Stable isotope labeling by amino acids in cell culture, SILAC, as a simple and accurate approach to expression proteomics. Mol Cell Proteomics 1: 376-386
-
(2002)
Mol Cell Proteomics
, vol.1
, pp. 376-386
-
-
Ong, S.-E.1
Blagoev, B.2
Kratchmarova, I.3
Kristensen, D.B.4
Steen, H.5
Pandey, A.6
Mann, M.7
-
54
-
-
84866265794
-
Noncanonical mismatch repair as a source of genomic instability in human cells
-
Peña-Diaz J, Bregenhorn S, Ghodgaonkar M, Follonier C, Artola-Borán M, Castor D, Lopes M, Sartori AA, Jiricny J, (2012) Noncanonical mismatch repair as a source of genomic instability in human cells. Mol Cell 47: 669-680
-
(2012)
Mol Cell
, vol.47
, pp. 669-680
-
-
Peña-Diaz, J.1
Bregenhorn, S.2
Ghodgaonkar, M.3
Follonier, C.4
Artola-Borán, M.5
Castor, D.6
Lopes, M.7
Sartori, A.A.8
Jiricny, J.9
-
55
-
-
33646036373
-
Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin
-
Penengo L, Mapelli M, Murachelli AG, Confalonieri S, Magri L, Musacchio A, Di Fiore PP, Polo S, Schneider TR, (2006) Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. Cell 124: 1183-1195
-
(2006)
Cell
, vol.124
, pp. 1183-1195
-
-
Penengo, L.1
Mapelli, M.2
Murachelli, A.G.3
Confalonieri, S.4
Magri, L.5
Musacchio, A.6
Di Fiore, P.P.7
Polo, S.8
Schneider, T.R.9
-
56
-
-
49849098630
-
Regulation of APC/C activators in mitosis and meiosis
-
Pesin JA, Orr-Weaver TL, (2008) Regulation of APC/C activators in mitosis and meiosis. Annu Rev Cell Dev Biol 24: 475-499
-
(2008)
Annu Rev Cell Dev Biol
, vol.24
, pp. 475-499
-
-
Pesin, J.A.1
Orr-Weaver, T.L.2
-
57
-
-
33747589184
-
The anaphase promoting complex/cyclosome: A machine designed to destroy
-
Peters J-M, (2006) The anaphase promoting complex/cyclosome: a machine designed to destroy. Nat Rev Mol Cell Biol 7: 644-656
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 644-656
-
-
Peters, J.-M.1
-
58
-
-
0034654399
-
The KEN box: An APC recognition signal distinct from the D box targeted by Cdh1
-
Pfleger CM, Kirschner MW, (2000) The KEN box: an APC recognition signal distinct from the D box targeted by Cdh1. Genes Dev 14: 655-665
-
(2000)
Genes Dev
, vol.14
, pp. 655-665
-
-
Pfleger, C.M.1
Kirschner, M.W.2
-
59
-
-
0035883946
-
Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex
-
Pfleger CM, Lee E, Kirschner MW, (2001) Substrate recognition by the Cdc20 and Cdh1 components of the anaphase-promoting complex. Genes Dev 15: 2396-2407
-
(2001)
Genes Dev
, vol.15
, pp. 2396-2407
-
-
Pfleger, C.M.1
Lee, E.2
Kirschner, M.W.3
-
60
-
-
79959555511
-
Cubism and the cell cycle: The many faces of the APC/C
-
Pines J, (2011) Cubism and the cell cycle: the many faces of the APC/C. Nat Rev Mol Cell Biol 12: 427-438
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 427-438
-
-
Pines, J.1
-
61
-
-
50549178479
-
Autoradiographic study of chromatid distribution of labeled DNA in two types of mammalian cells in vitro
-
Prescott DM, Bender MA, (1963) Autoradiographic study of chromatid distribution of labeled DNA in two types of mammalian cells in vitro. Exp Cell Res 29: 430-442
-
(1963)
Exp Cell Res
, vol.29
, pp. 430-442
-
-
Prescott, D.M.1
Bender, M.A.2
-
62
-
-
10344247126
-
Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry
-
Rape M, Kirschner MW, (2004) Autonomous regulation of the anaphase-promoting complex couples mitosis to S-phase entry. Nature 432: 588-595
-
(2004)
Nature
, vol.432
, pp. 588-595
-
-
Rape, M.1
Kirschner, M.W.2
-
63
-
-
38849199681
-
Visualizing spatiotemporal dynamics of multicellular cell-cycle progression
-
Sakaue-Sawano A, Kurokawa H, Morimura T, Hanyu A, Hama H, Osawa H, Kashiwagi S, Fukami K, Miyata T, Miyoshi H, Imamura T, Ogawa M, Masai H, Miyawaki A, (2008) Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 132: 487-498
-
(2008)
Cell
, vol.132
, pp. 487-498
-
-
Sakaue-Sawano, A.1
Kurokawa, H.2
Morimura, T.3
Hanyu, A.4
Hama, H.5
Osawa, H.6
Kashiwagi, S.7
Fukami, K.8
Miyata, T.9
Miyoshi, H.10
Imamura, T.11
Ogawa, M.12
Masai, H.13
Miyawaki, A.14
-
64
-
-
36549060102
-
Human CtIP promotes DNA end resection
-
Sartori AA, Lukas C, Coates J, Mistrik M, Fu S, Bartek J, Baer R, Lukas J, Jackson SP, (2007) Human CtIP promotes DNA end resection. Nature 450: 509-514
-
(2007)
Nature
, vol.450
, pp. 509-514
-
-
Sartori, A.A.1
Lukas, C.2
Coates, J.3
Mistrik, M.4
Fu, S.5
Bartek, J.6
Baer, R.7
Lukas, J.8
Jackson, S.P.9
-
65
-
-
34447651363
-
Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome
-
Semple JI, Smits VAJ, Fernaud J-R, Mamely I, Freire R, (2007) Cleavage and degradation of Claspin during apoptosis by caspases and the proteasome. Cell Death Differ 14: 1433-1442
-
(2007)
Cell Death Differ
, vol.14
, pp. 1433-1442
-
-
Semple, J.I.1
Smits, V.A.J.2
Fernaud, J.-R.3
Mamely, I.4
Freire, R.5
-
66
-
-
79952762235
-
Factors determining DNA double-strand break repair pathway choice in G2 phase
-
Shibata A, Conrad S, Birraux J, Geuting V, Barton O, Ismail A, Kakarougkas A, Meek K, Taucher-Scholz G, Löbrich M, Jeggo PA, (2011) Factors determining DNA double-strand break repair pathway choice in G2 phase. EMBO J 30: 1079-1092
-
(2011)
EMBO J
, vol.30
, pp. 1079-1092
-
-
Shibata, A.1
Conrad, S.2
Birraux, J.3
Geuting, V.4
Barton, O.5
Ismail, A.6
Kakarougkas, A.7
Meek, K.8
Taucher-Scholz, G.9
Löbrich, M.10
Jeggo, P.A.11
-
67
-
-
70849105394
-
Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis
-
Sigl R, Wandke C, Rauch V, Kirk J, Hunt T, Geley S, (2009) Loss of the mammalian APC/C activator FZR1 shortens G1 and lengthens S phase but has little effect on exit from mitosis. J Cell Sci 122: 4208-4217
-
(2009)
J Cell Sci
, vol.122
, pp. 4208-4217
-
-
Sigl, R.1
Wandke, C.2
Rauch, V.3
Kirk, J.4
Hunt, T.5
Geley, S.6
-
68
-
-
33747889217
-
Differential usage of non-homologous end-joining and homologous recombination in double strand break repair
-
Sonoda E, Hochegger H, Saberi A, Taniguchi Y, Takeda S, (2006) Differential usage of non-homologous end-joining and homologous recombination in double strand break repair. DNA Repair 5: 1021-1029
-
(2006)
DNA Repair
, vol.5
, pp. 1021-1029
-
-
Sonoda, E.1
Hochegger, H.2
Saberi, A.3
Taniguchi, Y.4
Takeda, S.5
-
69
-
-
84883599853
-
Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection
-
Steger M, Murina O, Hühn D, Ferretti LP, Walser R, Hänggi K, Lafranchi L, Neugebauer C, Paliwal S, Janscak P, Gerrits B, Del Sal G, Zerbe O, Sartori AA, (2013) Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection. Mol Cell 50: 333-343
-
(2013)
Mol Cell
, vol.50
, pp. 333-343
-
-
Steger, M.1
Murina, O.2
Hühn, D.3
Ferretti, L.P.4
Walser, R.5
Hänggi, K.6
Lafranchi, L.7
Neugebauer, C.8
Paliwal, S.9
Janscak, P.10
Gerrits, B.11
Del Sal, G.12
Zerbe, O.13
Sartori, A.A.14
-
70
-
-
25444493567
-
Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1
-
Stewart S, Fang G, (2005) Destruction box-dependent degradation of aurora B is mediated by the anaphase-promoting complex/cyclosome and Cdh1. Cancer Res 65: 8730-8735
-
(2005)
Cancer Res
, vol.65
, pp. 8730-8735
-
-
Stewart, S.1
Fang, G.2
-
71
-
-
27344435774
-
Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles
-
Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP, (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci USA 102: 15545-15550
-
(2005)
Proc Natl Acad Sci USA
, vol.102
, pp. 15545-15550
-
-
Subramanian, A.1
Tamayo, P.2
Mootha, V.K.3
Mukherjee, S.4
Ebert, B.L.5
Gillette, M.A.6
Paulovich, A.7
Pomeroy, S.L.8
Golub, T.R.9
Lander, E.S.10
Mesirov, J.P.11
-
72
-
-
0035890165
-
Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells
-
Sudo T, Ota Y, Kotani S, Nakao M, Takami Y, Takeda S, Saya H, (2001) Activation of Cdh1-dependent APC is required for G1 cell cycle arrest and DNA damage-induced G2 checkpoint in vertebrate cells. EMBO J 20: 6499-6508
-
(2001)
EMBO J
, vol.20
, pp. 6499-6508
-
-
Sudo, T.1
Ota, Y.2
Kotani, S.3
Nakao, M.4
Takami, Y.5
Takeda, S.6
Saya, H.7
-
73
-
-
0037157197
-
Degradation of human Aurora-A protein kinase is mediated by hCdh1
-
Taguchi SI, Honda K, Sugiura K, Yamaguchi A, Furukawa K, Urano T, (2002) Degradation of human Aurora-A protein kinase is mediated by hCdh1. FEBS Lett 519: 59-65
-
(2002)
FEBS Lett
, vol.519
, pp. 59-65
-
-
Taguchi, S.I.1
Honda, K.2
Sugiura, K.3
Yamaguchi, A.4
Furukawa, K.5
Urano, T.6
-
74
-
-
44949219325
-
The anaphase-promoting complex/cyclosome controls repair and recombination by ubiquitylating Rhp54 in fission yeast
-
Trickey M, Grimaldi M, Yamano H, (2008) The anaphase-promoting complex/cyclosome controls repair and recombination by ubiquitylating Rhp54 in fission yeast. Mol Cell Biol 28: 3905-3916
-
(2008)
Mol Cell Biol
, vol.28
, pp. 3905-3916
-
-
Trickey, M.1
Grimaldi, M.2
Yamano, H.3
-
75
-
-
4444321565
-
Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells
-
van Vugt MATM, Bràs A, Medema RH, (2004) Polo-like kinase-1 controls recovery from a G2 DNA damage-induced arrest in mammalian cells. Mol Cell 15: 799-811
-
(2004)
Mol Cell
, vol.15
, pp. 799-811
-
-
Van Vugt, M.1
Bràs, A.2
Medema, R.H.3
-
76
-
-
12444311754
-
Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells
-
Wäsch R, Engelbert D, (2005) Anaphase-promoting complex-dependent proteolysis of cell cycle regulators and genomic instability of cancer cells. Oncogene 24: 1-10
-
(2005)
Oncogene
, vol.24
, pp. 1-10
-
-
Wäsch, R.1
Engelbert, D.2
-
77
-
-
33846194613
-
KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions
-
White DE, Negorev D, Peng H, Ivanov AV, Maul GG, Rauscher FJ, (2006) KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions. Cancer Res 66: 11594-11599
-
(2006)
Cancer Res
, vol.66
, pp. 11594-11599
-
-
White, D.E.1
Negorev, D.2
Peng, H.3
Ivanov, A.V.4
Maul, G.G.5
Rauscher, F.J.6
-
78
-
-
77953810029
-
P53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress
-
Wiebusch L, Hagemeier C, (2010) p53- and p21-dependent premature APC/C-Cdh1 activation in G2 is part of the long-term response to genotoxic stress. Oncogene 29: 3477-3489
-
(2010)
Oncogene
, vol.29
, pp. 3477-3489
-
-
Wiebusch, L.1
Hagemeier, C.2
-
79
-
-
0029965507
-
Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells
-
Yamamoto A, Taki T, Yagi H, Habu T, Yoshida K, Yoshimura Y, Yamamoto K, Matsushiro A, Nishimune Y, Morita T, (1996) Cell cycle-dependent expression of the mouse Rad51 gene in proliferating cells. Mol Gen Genet 251: 1-12
-
(1996)
Mol Gen Genet
, vol.251
, pp. 1-12
-
-
Yamamoto, A.1
Taki, T.2
Yagi, H.3
Habu, T.4
Yoshida, K.5
Yoshimura, Y.6
Yamamoto, K.7
Matsushiro, A.8
Nishimune, Y.9
Morita, T.10
-
80
-
-
33745614048
-
BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP
-
Yu X, Fu S, Lai M, Baer R, Chen J, (2006) BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev 20: 1721-1726
-
(2006)
Genes Dev
, vol.20
, pp. 1721-1726
-
-
Yu, X.1
Fu, S.2
Lai, M.3
Baer, R.4
Chen, J.5
-
81
-
-
77957947338
-
Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage
-
Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh D-C, Hathaway N, Dimova N, Cuny GD, King RW, (2010) Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell 18: 382-395
-
(2010)
Cancer Cell
, vol.18
, pp. 382-395
-
-
Zeng, X.1
Sigoillot, F.2
Gaur, S.3
Choi, S.4
Pfaff, K.L.5
Oh, D.-C.6
Hathaway, N.7
Dimova, N.8
Cuny, G.D.9
King, R.W.10
-
82
-
-
77952586024
-
Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress
-
Zhang L, Park C-H, Wu J, Kim H, Liu W, Fujita T, Balasubramani M, Schreiber EM, Wang X-F, Wan Y, (2010) Proteolysis of Rad17 by Cdh1/APC regulates checkpoint termination and recovery from genotoxic stress. EMBO J 29: 1726-1737
-
(2010)
EMBO J
, vol.29
, pp. 1726-1737
-
-
Zhang, L.1
Park, C.-H.2
Wu, J.3
Kim, H.4
Liu, W.5
Fujita, T.6
Balasubramani, M.7
Schreiber, E.M.8
Wang, X.-F.9
Wan, Y.10
-
83
-
-
33746601439
-
Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway
-
Ziv Y, Bielopolski D, Galanty Y, Lukas C, Taya Y, Schultz DC, Lukas J, Bekker-Jensen S, Bartek J, Shiloh Y, (2006) Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM- and KAP-1 dependent pathway. Nat Cell Biol 8: 870-876
-
(2006)
Nat Cell Biol
, vol.8
, pp. 870-876
-
-
Ziv, Y.1
Bielopolski, D.2
Galanty, Y.3
Lukas, C.4
Taya, Y.5
Schultz, D.C.6
Lukas, J.7
Bekker-Jensen, S.8
Bartek, J.9
Shiloh, Y.10
|