A Synthetic Lethal Interaction between APC/C and Topoisomerase Poisons Uncovered by Proteomic Screens

Cell Reports

Volumn 6, Issue 4, 2014, Pages 670-683

  Eguren, Manuel ^a   Álvarez Fernández, Mónica ^a   García, Fernando ^a   López Contreras, Andrés J ^a   Fujimitsu, Kazuyuki ^b   Yaguchi, Hiroko ^b   Luque García, JoséLuis ^c   Fernández Capetillo, Oscar ^a   Muñoz, Javier ^a   Yamano, Hiroyuki ^b   Malumbres, Marcos ^a  

^a Centro Nacional de Investigaciones Oncológicas   (Spain)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; DNA TOPOISOMERASE; FIZZY RELATED PROTEIN; KINESIN 5; MONASTROL; CELL PROTEIN; D BOX PROTEIN; ETOPOSIDE; KEN BOX PROTEIN; KINESIN EG5 PROTEIN; TOPOISOMERASE 2ALPHA; UNCLASSIFIED DRUG; UVOMORULIN;

ANIMAL CELL; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA DAMAGE; DOWN REGULATION; DRUG EFFICACY; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MITOSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; PROTEOMICS; RNA INTERFERENCE; TRANSCRIPTION REGULATION; UBIQUITINATION; UPREGULATION; ANIMAL EXPERIMENT; ANIMAL TISSUE; CORRELATIONAL STUDY; EMBRYO; MOUSE; PROTEIN ANALYSIS;

MAMMALIA;

ANIMALS; ANTIGENS, NEOPLASM; BINDING SITES; CDH1 PROTEINS; DNA TOPOISOMERASES, TYPE II; DNA-BINDING PROTEINS; GENOMIC INSTABILITY; HEK293 CELLS; HELA CELLS; HUMANS; KINESIN; MICE; PROTEIN BINDING; PROTEOME; PYRIMIDINES; THIONES; TOPOISOMERASE II INHIBITORS; UBIQUITINATION; XENOPUS;

EID: 84896701573     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2014.01.017     Document Type: Article

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