KAP1, a novel substrate for PIKK family members, colocalizes with numerous damage response factors at DNA lesions

Cancer Research

Volumn 66, Issue 24, 2006, Pages 11594-11599

  White, David E ^a   Negorev, Dmitri ^a   Peng, Hongzhuang ^a   Ivanov, Alexey V ^a   Maul, Gerd G ^a   Rauscher III, Frank J ^a  

^a WISTAR INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

KRUPPEL ASSOCIATED BOX ZINC FINGER PROTEIN ASSOCIATED PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; SERINE; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; CELLULAR DISTRIBUTION; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; DNA REPAIR; DNA STRAND BREAKAGE; HUMAN; HUMAN CELL; IONIZING RADIATION; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION;

CELL DIVISION; CELL LINE, TUMOR; CELL NUCLEUS; CULTURE MEDIA; DNA DAMAGE; DNA-BINDING PROTEINS; GENES, BRCA1; HUMANS; PHOSPHORYLATION; PHOSPHOSERINE; REPRESSOR PROTEINS; SUBSTRATE SPECIFICITY;

EID: 33846194613     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-06-4138     Document Type: Article

References (20)

1. Ziv Y, Bar-Shira A, Pecker I, et al. Recombinant ATM protein complements the cellular A-T phenotype. Oncogene 1997;15:159-67.
2. Morrison C, Sonoda E, Takao N, Shinohara A, Yamamoto K, Takeda S. The controlling role of ATM in homologous recombinational repair of DNA damage. EMBO J 2000;19:463-71.
3. Burma S, Chen BP, Murphy M, Kurimasa A, Chen DJ. ATM phosphorylates histone H2AX in response to DNA double-strand breaks. J Biol Chem 2001;276:42462-7.
4. Yamane K, Wu X, Chen J. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Mol Cell Biol 2002;22:555-66.
5. Anderson L, Henderson C, Adachi Y. Phosphorylation and rapid relocalization of 53BP1 to nuclear foci upon DNA damage. Mol Cell Biol 2001;21:1719-29.
6. Cortez D, Wang Y, Qin J, Elledge SJ. Requirement of ATM-dependent phosphorylation of brca1 in the DNA damage response to double-strand breaks. Science 1999;286:1162-6.
7. Andegeko Y, Moyal L, Mittelman L, Tsarfaty I, Shiloh Y, Rotman G. Nuclear retention of ATM at sites of DNA double strand breaks. J Biol Chem 2001;276:38224-30.
8. Allen C, Halbrook J, Nickoloff JA. Interactive competition between homologous recombination and non-homologous end joining. Mol Cancer Res 2003;1:913-20.
9. Jhappan C, Morse HC III, Fleischmann RD, Gottesman MM, Merlino G. DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus. Nat Genet 1997;17:483-6.
10. Ward IM, Minn K, Chen J. UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. J Biol Chem 2004;279:9677-80.
11. Sripathy SP, Stevens J, Schultz DC. The KAP1 corepressor functions to coordinate the assembly of de novo HP1 demarcated microenvironments of heterochromatin required for KRAB zinc finger protein mediated transcriptional repression. Mol Cell Biol 2006;26:8623-38.
12. Peng H, Begg GE, Schultz DC, et al. Reconstitution of the KRAB-KAP-1 represser complex: a model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions. J Mol Biol 2000;295:1139-62.
13. Lechner MS, Begg GE, Speicher DW, Rauscher FJ III. Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: direct chromoshadow domain-KAP-1 corepressor interaction is essential. Mol Cell Biol 2000;20:6449-65.
14. Schultz DC, Ayyanathan K, Negorev D, Maul GG, Rauscher FJ III. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-linger proteins. Genes Dev 2002;16:919-32.
15. Schulte DC, Friedman JR, Rauscher FJ III. Targeting histone deacetylase complexes via KRAB-zinc finger proteins: the PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD. Genes Dev 2001;15:428-43.
16. Klenova E, Chernukhin I, Inoue T, Shamsuddin S, Norton J. Immunoprecipitation techniques for the analysis of transcription factor complexes. Methods 2002;26:254-9.
17. Zheng L, Pan H, Li S, et al. Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1. Mol Cell 2000;6:757-68.
18. Deriano L, Guipaud O, Merle-Beral H, et al. Human chronic lymphocytic leukemia B cells can escape DNA damage-induced apoptosis through the nonhomologous end-joining DNA repair pathway. Blood 2005;105:4776-83.
19. Sarkaria JN, Busby EC, Tibbetts RS, et al. Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine. Cancer Res 1999;59:4375-82.
20. Ziv Y, Bielopolski D, Galanty Y, et al. Chromatin relaxation in response to DNA double-strand breaks is modulated by a novel ATM-and KAP-1 dependent pathway. Nat Cell Biol 2006;8:870-6.