Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage

Cancer Cell

Volumn 18, Issue 4, 2010, Pages 382-395

  Zeng, Xing ^a   Sigoillot, Frederic ^a   Gaur, Shantanu ^a   Choi, Sungwoon ^b   Pfaff, Kathleen L ^a   Oh, Dong Chan ^a,c   Hathaway, Nathaniel ^a   Dimova, Nevena ^a   Cuny, Gregory D ^b   King, Randall W ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c Department of Life and Nanopharmaceutical Science   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

ANAPHASE PROMOTING COMPLEX; APC PROTEIN; PROTEASOME INHIBITOR; TOSYLARGININE METHYL ESTER; UBIQUITIN PROTEIN LIGASE; UVOMORULIN; ENZYME INHIBITOR; MUTANT PROTEIN; PRODRUG; PROTEASOME; PROTEIN BINDING;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; METAPHASE; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS INHIBITION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; SPINDLE CELL; ANIMAL; ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; ENZYME ACTIVATION; HELA CELL LINE; METABOLISM; MICROTUBULE; PATHOLOGY; PROTEIN SYNTHESIS; SPINDLE APPARATUS; XENOPUS;

ANAPHASE-PROMOTING COMPLEX-CYCLOSOME; ANIMALS; ENZYME ACTIVATION; ENZYME INHIBITORS; HELA CELLS; HUMANS; METAPHASE; MICROTUBULES; MITOSIS; MUTANT PROTEINS; PRODRUGS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEASOME INHIBITORS; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; SPINDLE APPARATUS; TOSYLARGININE METHYL ESTER; UBIQUITIN-PROTEIN LIGASE COMPLEXES; XENOPUS;

EID: 77957947338     PISSN: 15356108     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ccr.2010.08.010     Document Type: Article

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