Inhibition of secreted frizzled-related protein 5 improves glucose metabolism

American Journal of Physiology - Endocrinology and Metabolism

Volumn 307, Issue 12, 2014, Pages E1144-E1152

  Rulifson, Ingrid C ^a   Majeti, Jiangwen Z ^a   Xiong, Yumei ^a   Hamburger, Agi ^a   Lee, Ki Jeong ^a   Miao, Li ^a   Lu, Mei ^a   Gardner, Jonitha ^a   Gong, Yan ^a   Wu, Hai ^a   Case, Ryan ^a   Yeh, Wen Chen ^a   Richards, William G ^a   Baribault, Helene ^a   Yang, Li ^a  

^a AMGEN INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C PEPTIDE; GLUCOSE; INSULIN; MESSENGER RNA; MONOCLONAL ANTIBODY; PROINSULIN; SECRETED FRIZZLED RELATED PROTEIN 5; IMMUNOGLOBULIN G; SFRP5 PROTEIN, MOUSE; SIGNAL PEPTIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; GENE OVEREXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE INTOLERANCE; GLUCOSE METABOLISM; GLUCOSE TOLERANCE; HYPERGLYCEMIA; IMPAIRED GLUCOSE TOLERANCE; IN VITRO STUDY; IN VIVO STUDY; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID DIET; MOUSE; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PROTEIN EXPRESSION; ANIMAL; C57BL MOUSE; COMPLICATION; DRUG EFFECTS; GENETICS; IMMUNOLOGY; MALE; METABOLISM; PHYSIOLOGY; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, MONOCLONAL; DIABETES MELLITUS, TYPE 2; GLUCOSE; IMMUNOGLOBULIN G; INSULIN-SECRETING CELLS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MALE; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; OBESITY;

EID: 84918840801     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00283.2014     Document Type: Article

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