Plasma SFRP5 levels are decreased in Chinese subjects with obesity and type 2 diabetes and negatively correlated with parameters of insulin resistance

Diabetes Research and Clinical Practice

Volumn 99, Issue 3, 2013, Pages 391-395

  Hu, Zhenping ^a   Deng, Huacong ^a   Qu, Hua ^a  

^a THE FIRST AFFILIATED HOSPITAL OF CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Insulin resistance; Obesity; Secreted frizzled related protein 5; Type 2 diabetes

Indexed keywords

GLUCOSE; HEMOGLOBIN A1C; INSULIN; INTERLEUKIN 6; LIPID; SECRETED FRIZZLED RELATED PROTEIN 5; TRIACYLGLYCEROL;

ADULT; ARTICLE; BODY FAT; BODY MASS; CHINESE; CONTROLLED STUDY; FEMALE; GLUCOSE TOLERANCE; HOMEOSTASIS; HUMAN; INFLAMMATION; INSULIN RESISTANCE; LIPID BLOOD LEVEL; LIPID METABOLISM; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PROTEIN BLOOD LEVEL; WAIST CIRCUMFERENCE; WAIST HIP RATIO;

ASIAN CONTINENTAL ANCESTRY GROUP; BODY MASS INDEX; CHINA; DIABETES MELLITUS, TYPE 2; EYE PROTEINS; FEMALE; GLYCOLIPIDS; HEMOGLOBIN A, GLYCOSYLATED; HUMANS; INSULIN; INSULIN RESISTANCE; INTERLEUKIN-6; MALE; MEMBRANE PROTEINS; MIDDLE AGED; OBESITY;

EID: 84876179013     PISSN: 01688227     EISSN: 18728227     Source Type: Journal    
DOI: 10.1016/j.diabres.2012.11.026     Document Type: Article

References (17)

1. Galic S., Oakhill J.S., Steinberg G.R. Adipose tissue as an endocrine organ. Mol Cell Endocrinol 2010, 316:129-139.
2. Ouchi N., Higuchi A., Ohashi K., Oshima Y., Gokce N., Shibata R., et al. Sfrp5 is an anti-inflammatory adipokine that modulates metabolic dysfunction in obesity. Science 2010, 329:454-457.
3. World Health Organization Definition, diagnosis and classification of diabetes mellitus and its complications, Report of a WHO Consultation. Part 1. Diagnosis and classification of diabetes mellitus 1999, Department of Noncommunicable Disease Surveillance, Geneva, WHO/NCD/NCS/99.2.
4. The Asia-Pacific perspective: redefining obesity and its treatment 2000, Health Communications Australia Pty Ltd, WHO/IASO/IOTF. Full document available from: http://www.idi.org.au/obesity_report.htm.
5. Finch P.W., He X., Kelley M.J., Uren A., Schaudies R.P., Popescu N.C., et al. Purification and molecular cloning of a secreted, frizzled-related antagonist of Wnt action. Proc Natl Acad Sci USA 1997, 94:6770-6775.
6. Matsuzawa Y. Adiponectin: a key player in obesity related disorders. Curr Pharm Des 2010, 16:1896-1901.
7. Bottner A., Kratzsch J., Muller G., Kapellen T.M., Bluher S., Keller E., et al. Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels. J Clin Endocrinol Metab 2004, 89:4053-4061.
8. Bird L. Inflammation: the fat controller. Nat Rev Immunol 2010, 10:540.
9. Schulte D.M., Muller N., Neumann K., Oberhauser F., Faust M., Gudelhofer H., et al. Pro-inflammatory wnt5a and anti-inflammatory sFRP5 are differentially regulated by nutritional factors in obese human subjects. PLoS ONE 2012, 7:e32437.
10. Fasshauer M., Klein J., Neumann S., Eszlinger M., Paschke R. Hormonal regulation of adiponectin gene expression in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2002, 290:1084-1089.
11. Simons P.J., van den Pangaart P.S., Aerts J.M., Boon L. Pro-inflammatory delipidizing cytokines reduce adiponectin secretion from human adipocytes without affecting adiponectin oligomerization. J Endocrinol 2007, 192:289-299.
12. Tan B.K., Adya R., Farhatullah S., Lewandowski K.C., O'Hare P., Lehnert H., et al. Omentin-1, a novel adipokine, is decreased in overweight insulin-resistant women with polycystic ovary syndrome: ex vivo and in vivo regulation of omentin-1 by insulin and glucose. Diabetes 2008, 57:801-808.
13. Kralisch S., Klein J., Lossner U., Bluher M., Paschke R., Stumvoll M., et al. Interleukin-6 is a negative regulator of visfatin gene expression in 3T3-L1 adipocytes. Am J Physiol Endocrinol Metab 2005, 289:E586-E590.
14. Lv C., Jiang Y., Wang H., Chen B. Sfrp5 expression and secretion in adipocyte are upregulated during the differentiation and are negatively correlated with insulin resistance. Cell Biol Int 2012, http://www.ncbi.nlm.nih.gov/pubmed?term=Sfrp5%20expression%20and%20secretion%20in%20adipocyte%20are%20upregulated%20during%20the%20differentiation%20and%20are%20negatively%20correlated%20with%20insulin%20resistance.
15. Lagathu C., Christodoulides C., Virtue S., Cawthorn W.P., Franzin C., Kimber W.A., et al. Dact1, a nutritionally regulated preadipocyte gene, controls adipogenesis by coordinating the Wnt/beta-catenin signaling network. Diabetes 2009, 58:609-619.
16. Nagle C.A., Klett E.L., Coleman R.A. Hepatic triacylglycerol accumulation and insulin resistance. J Lipid Res 2009, 50(Suppl):S74-S79.
17. Hegarty B.D., Furler S.M., Ye J., Cooney G.J., Kraegen E.W. The role of intramuscular lipid in insulin resistance. Acta Physiol Scand 2003, 178:373-383.