Downregulation of Sfrp5 promotes beta cell proliferation during obesity in the rat

Diabetologia

Volumn 56, Issue 11, 2013, Pages 2446-2455

  Rebuffat, Sandra A ^a,b   Oliveira, Joana M ^a,b   Altirriba, Jordi ^a,b   Palau, Nuria ^a,b   Garcia, Ainhoa ^a,b   Esteban, Yaiza ^a,b   Nadal, Belen ^a,b,c   Gomis, Ramon ^a,b,c,d  

^a INSTITUT D INVESTIGACIONS BIOMÈDIQUES AUGUST PI I SUNYER IDIBAPS   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF BARCELONA   (Spain)

^d HOSPITAL CLÍNIC   (Spain)

Author keywords

IGF binding protein 3; Obesity; Pancreatic beta cells; Proliferation; Secreted frizzled related protein 5; Wnt signalling pathway

Indexed keywords

SECRETED FRIZZLED RELATED PROTEIN 5; SOMATOMEDIN BINDING PROTEIN 3; WNT PROTEIN;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FOOD INTAKE; GENE EXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; INTRAABDOMINAL FAT; LOSS OF FUNCTION MUTATION; MICROARRAY ANALYSIS; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; RAT; REAL TIME POLYMERASE CHAIN REACTION; TRANSCRIPTOMICS; WNT SIGNALING PATHWAY;

ANIMALS; CELL PROLIFERATION; INSULIN-SECRETING CELLS; MALE; MEMBRANE PROTEINS; OBESITY; RATS; RATS, WISTAR;

EID: 84885740284     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-013-3030-x     Document Type: Article

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