β-cell failure in diet-induced obese mice stratified according to body weight gain: Secretory dysfunction and altered islet lipid metabolism without steatosis or reduced β-cell mass

Diabetes

Volumn 59, Issue 9, 2010, Pages 2178-2187

  Peyot, Marie Line ^a   Pepin, Emilie ^a   Lamontagne, Julien ^a   Latour, Martin G ^a   Zarrouki, Bader ^a   Lussier, Roxane ^a   Pineda, Marco ^a   Jetton, Thomas L ^b   Madiraju, S R Murthy ^a   Joly, Erik ^a   Prentki, Marc ^a,c  

^a CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^b UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CHOLESTEROL; GLUCOSE; LIPID; POTASSIUM CHLORIDE; TRIACYLGLYCEROL; ADENOSINE TRIPHOSPHATE; FAT INTAKE; INSULIN; PROINSULIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ESTERIFICATION; FATTY ACID METABOLISM; GLUCOSE HOMEOSTASIS; HYPERGLYCEMIA; INSULIN RESISTANCE; LIPID BLOOD LEVEL; LIPID DIET; LIPID METABOLISM; LIPOLYSIS; MALE; MOUSE; NONHUMAN; OBESITY; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; WEIGHT GAIN; ANIMAL; BLOOD; C57BL MOUSE; CELL DIVISION; CHEMICALLY INDUCED; CYTOLOGY; DIET; FAT INTAKE; GLUCOSE CLAMP TECHNIQUE; METABOLISM; PANCREAS ISLET; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ADENOSINE TRIPHOSPHATE; ANIMALS; CELL DIVISION; DIET; DIETARY FATS; GLUCOSE; GLUCOSE CLAMP TECHNIQUE; INSULIN; INSULIN-SECRETING CELLS; ISLETS OF LANGERHANS; LIPOLYSIS; MALE; MICE; MICE, INBRED C57BL; OBESITY; PROINSULIN; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; WEIGHT GAIN;

EID: 77956373690     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db09-1452     Document Type: Article

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