Blockage of melanocortin-4 receptors by intranasal HS014 attenuates single prolonged stress-triggered changes in several brain regions

Journal of Neurochemistry

Volumn 131, Issue 6, 2014, Pages 825-835

  Serova, Lidia I ^a   Laukova, Marcela ^a,b   Alaluf, Lishay G ^a   Sabban, Esther L ^a  

^a NEW YORK MEDICAL COLLEGE   (United States)

^b INSTITUTE OF EXPERIMENTAL ENDOCRINOLOGY   (Slovakia)

Author keywords

corticotrophin releasing hormone; dopamine hydroxylase; glucocorticoid receptor; intranasal infusion; locus coeruleus; tyrosine hydroxylase

Indexed keywords

BETA INTERMEDIN[11-22][11 (N ACETYLCYSTEINE) 14 [3 (2 NAPHTHYL) DEXTRO ALANINE] 18 CYSTEINE 22 ASPARTIC ACID AMIDE] 11,18 CYCLIC DISULFIDE; CORTICOTROPIN RELEASING FACTOR; DOPAMINE BETA MONOOXYGENASE; FK 506 BINDING PROTEIN; GLUCOCORTICOID RECEPTOR; MELANOCORTIN 4 RECEPTOR; TYROSINE 3 MONOOXYGENASE; CORTICOSTERONE; CYCLOPEPTIDE; HS014 CYCLIC PEPTIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN REGION; CONTROLLED STUDY; CORTICOTROPHIN RELEASING HORMONE GENE; DRUG MECHANISM; GENE EXPRESSION; HIPPOCAMPUS; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; LOCUS CERULEUS; MEDIOBASAL HYPOTHALAMUS; NERVE STIMULATION; NEUROANATOMY; NONHUMAN; POSTTRAUMATIC STRESS DISORDER; RAT; ANIMAL; ANXIETY; BLOOD; DRUG EFFECTS; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; INTRANASAL DRUG ADMINISTRATION; MALE; MENTAL STRESS; METABOLISM; SPRAGUE DAWLEY RAT;

ANIMALIA; RATTUS;

ADMINISTRATION, INTRANASAL; ANIMALS; ANXIETY; CORTICOSTERONE; CORTICOTROPIN-RELEASING HORMONE; HIPPOCAMPUS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; MALE; PEPTIDES, CYCLIC; PITUITARY-ADRENAL SYSTEM; RATS, SPRAGUE-DAWLEY; RECEPTOR, MELANOCORTIN, TYPE 4; RECEPTORS, GLUCOCORTICOID; STRESS, PSYCHOLOGICAL;

EID: 84918824000     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/jnc.12847     Document Type: Article

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