Novel aspects of glucocorticoid actions

Journal of Neuroendocrinology

Volumn 26, Issue 9, 2014, Pages 557-572

  Uchoa, E T ^a   Aguilera, G ^b   Herman, J P ^c   Fiedler, J L ^d   Deak, T ^e   de Sousa, M B C ^f  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH AND HUMAN DEVELOPMENT   (United States)

^c UNIVERSITY OF CINCINNATI   (United States)

^d UNIVERSITY OF CHILE   (Chile)

^e BINGHAMTON UNIVERSITY   (United States)

^f FEDERAL UNIVERSITY OF RIO GRANDE DO NORTE   (Brazil)

Author keywords

Feedback; Food intake; Glucocorticoids; HPA axis; Immune system; Neuroplasticity

Indexed keywords

CORTICOTROPIN; CORTICOTROPIN RELEASING FACTOR; GLUCOCORTICOID; MINERALOCORTICOID RECEPTOR; NEUROPEPTIDE; AUTACOID; GLUCOCORTICOID RECEPTOR;

APOPTOSIS; BEHAVIOR; CELL SURVIVAL; CIRCADIAN RHYTHM; CORTICOTROPIN RELEASE; DENDRITIC SPINE; ENERGY; FACILITATION; FEEDING BEHAVIOR; GENOMICS; GLUTAMATERGIC NEUROTRANSMISSION; HIPPOCAMPUS; HOMEOSTASIS; HORMONE RELEASE; HYPOTHALAMUS HYPOPHYSIS ADRENAL SYSTEM; IMMEDIATE EARLY GENE; IMMUNOREGULATION; INFLAMMATION; LIMBIC CORTEX; MEMORY CONSOLIDATION; METABOLIC REGULATION; NEGATIVE FEEDBACK; NEUROENDOCRINE SYSTEM; NEUROMODULATION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; REVIEW; STRESS; SURVIVAL; VERTEBRATE; ANIMAL; BIOLOGICAL MODEL; BRAIN; EATING; FEEDBACK SYSTEM; HYPOPHYSIS ADRENAL SYSTEM; HYPOTHALAMUS HYPOPHYSIS SYSTEM; NERVE CELL PLASTICITY; NEUROSECRETION; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

ANIMALS; BRAIN; EATING; FEEDBACK, PHYSIOLOGICAL; GLUCOCORTICOIDS; HYPOTHALAMO-HYPOPHYSEAL SYSTEM; INFLAMMATION MEDIATORS; MODELS, BIOLOGICAL; NEURONAL PLASTICITY; NEUROSECRETORY SYSTEMS; PITUITARY-ADRENAL SYSTEM; RECEPTORS, GLUCOCORTICOID; RECEPTORS, MINERALOCORTICOID; STRESS, PHYSIOLOGICAL;

EID: 84906496368     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/jne.12157     Document Type: Review

References (181)

1. Johnson EO, Kamilaris TC, Chrousos GP, Gold PW. Mechanisms of stress: a dynamic overview of hormonal and behavioral homeostasis. Neurosci Biobehav Rev 1992; 16: 115-130.
2. Smith SM, Vale WW. The role of the hypothalamic-pituitary-adrenal axis in neuroendocrine responses to stress. Dialogues Clin Neurosci 2006; 8: 383-395.
3. Lightman SL, Wiles CC, Atkinson HC, Henley DE, Russell GM, Leendertz JA, McKenna MA, Spiga F, Wood SA, Conway-Campbell BL. The significance of glucocorticoid pulsatility. Eur J Pharmacol 2008; 583: 255-262.
4. Joëls M, de Kloet ER. Mineralocorticoid and glucocorticoid receptors in the brain. Implications for ion permeability and transmitter systems. Prog Neurobiol 1994; 43: 1-36.
5. Baker ME, Funder JW, Kattoula SR. Evolution of hormone selectivity in glucocorticoid and mineralocorticoid receptors. J Steroid Biochem Mol Biol 2013; 137: 57-70.
6. Grad I, Picard D. The glucocorticoid responses are shaped by molecular chaperones. Mol Cell Endocrinol 2007; 275: 2-12.
7. Hill MN, Tasker JG. Endocannabinoid signaling, glucocorticoid-mediated negative feedback, and regulation of the hypothalamic-pituitary-adrenal axis. Neuroscience 2012; 204: 5-16.
8. Evanson NK, Herman JP, Sakai RR, Krause EG. Nongenomic actions of adrenal steroids in the central nervous system. J Neuroendocrinol 2010; 22: 846-861.
9. Herman JP, McKlveen JM, Solomon MB, Carvalho-Netto E, Myers B. Neural regulation of the stress response: glucocorticoid feedback mechanisms. Braz J Med Biol Res 2012; 45: 292-298.
10. Viengchareun S, Le Menuet D, Martinerie L, Munier M, Pascual-Le Tallec L, Lombès M. The mineralocorticoid receptor: insights into its molecular and (patho)physiological biology. Nucl Recept Signal 2007; 5: e012.
11. Berardelli R, Karamouzis I, D'Angelo V, Zichi C, Fussotto B, Giordano R, Ghigo E, Arvat E. Role of mineralocorticoid receptors on the hypothalamus-pituitary-adrenal axis in humans. Endocrine 2013; 43: 51-58.
12. Geerling JC, Loewy AD. Aldosterone in the brain. Am J Physiol Renal Physiol 2009; 297: F559-F576.
13. Sawchenko PE. Evidence for a local site of action for glucocorticoids in inhibiting CRF and vasopressin expression in the paraventricular nucleus. Brain Res 1987; 403: 213-224.
14. Plotsky PM, Otto S, Sapolsky RM. Inhibition of immunoreactive corticotropin-releasing factor secretion into the hypophysial-portal circulation by delayed glucocorticoid feedback. Endocrinology 1986; 119: 1126-1130.
15. Plotsky PM, Sawchenko PE. Hypophysial-portal plasma levels, median eminence content, and immunohistochemical staining of corticotropin-releasing factor, arginine vasopressin, and oxytocin after pharmacological adrenalectomy. Endocrinology 1987; 120: 1361-1369.
16. Dallman MF, Akana SF, Levin N, Walker CD, Bradbury MJ, Suemaru S, Scribner KS. Corticosteroids and the control of function in the hypothalamo-pituitary-adrenal (HPA) axis. Ann N Y Acad Sci 1994; 746: 22-28.
17. Gagner JP, Drouin J. Opposite regulation of pro-opiomelanocortin gene transcription by glucocorticoids and CRH. Mol Cell Endocrinol 1985; 40: 25-32.
18. Eberwine JH, Jonassen JA, Evinger MJ, Roberts JL. Complex transcriptional regulation by glucocorticoids and corticotropin-releasing hormone of proopiomelanocortin gene expression in rat pituitary cultures. DNA 1987; 6: 483-492.
19. Aguilera G, Liu Y. The molecular physiology of CRH neurons. Front Neuroendocrinol 2012; 33: 17.
20. Ma XM, Camacho C, Aguilera G. Regulation of corticotropin-releasing hormone (CRH) transcription and CRH mRNA stability by glucocorticoids. Cell Mol Neurobiol 2001; 21: 465-475.
21. Spencer CM, Eberwine J. Cytoplasmic proteins interact with a translational control element in the protein-coding region of proopiomelanocortin mRNA. DNA Cell Biol 1999; 18: 39-49.
22. Evans AN, Liu Y, Macgregor R, Huang V, Aguilera G. Regulation of hypothalamic corticotropin releasing hormone transcription by elevated glucocorticoids. Mol Endocrinol 2013; 27: 1796-1807.
23. Ma XM, Aguilera G. Differential regulation of corticotropin-releasing hormone and vasopressin transcription by glucocorticoids. Endocrinology 1999; 140: 5642-5650.
24. Kovács KJ, Földes A, Sawchenko PE. Glucocorticoid negative feedback selectively targets vasopressin transcription in parvocellular neurosecretory neurons. J Neurosci 2000; 20: 3843-3852.
25. Liposits Z, Uht RM, Harrison RW, Gibbs FP, Paull WK, Bohn MC. Ultrastructural localization of glucocorticoid receptor (GR) in hypothalamic paraventricular neurons synthesizing corticotropin releasing factor (CRF). Histochemistry 1987; 87: 407-412.
26. Fenoglio KA, Brunson KL, Avishai-Eliner S, Chen Y, Baram TZ. Region-specific onset of handling-induced changes in corticotropin-releasing factor and glucocorticoid receptor expression. Endocrinology 2004; 145: 2702-2706.
27. Harbuz MS, Lightman SL. Glucocorticoid inhibition of stress-induced changes in hypothalamic corticotrophin-releasing factor messenger RNA and proenkephalin A messenger RNA. Neuropeptides 1989; 14: 17-20.
28. Makino S, Smith MA, Gold PW. Increased expression of corticotropin-releasing hormone and vasopressin messenger ribonucleic acid (mRNA) in the hypothalamic paraventricular nucleus during repeated stress: association with reduction in glucocorticoid receptor mRNA levels. Endocrinology 1995; 136: 3299-3309.
29. Ma XM, Lightman SL, Aguilera G. Vasopressin and corticotropin-releasing hormone gene responses to novel stress in rats adapted to repeated restraint. Endocrinology 1999; 140: 3623-3632.
30. Kóvacs KJ, Makara GB. Corticosterone and dexamethasone act at different brain sites to inhibit adrenalectomy-induced adrenocorticotropin hypersecretion. Brain Res 1988; 474: 205-210.
31. Malkoski SP, Handanos CM, Dorin RI. Localization of a negative glucocorticoid response element of the human corticotropin releasing hormone gene. Mol Cell Endocrinol 1997; 127: 189-199.
32. Malkoski SP, Dorin RI. Composite glucocorticoid regulation at a functionally defined negative glucocorticoid response element of the human corticotropin-releasing hormone gene. Mol Endocrinol 1999; 13: 1629-1644.
33. Guardiola-Diaz HM, Kolinske JS, Gates LH, Seasholtz AF. Negative glucorticoid regulation of cyclic adenosine 3', 5'-monophosphate-stimulated corticotropin-releasing hormone-reporter expression in AtT-20 cells. Mol Endocrinol 1996; 10: 317-329.
34. Ma XM, Levy A, Lightman SL. Rapid changes of heteronuclear RNA for arginine vasopressin but not for corticotropin releasing hormone in response to acute corticosterone administration. J Neuroendocrinol 1997; 9: 723-728.
35. Shepard JD, Liu Y, Sassone-Corsi P, Aguilera G. Role of glucocorticoids and cAMP-mediated repression in limiting corticotropin-releasing hormone transcription during stress. J Neurosci 2005; 25: 4073-4081.
36. Liu Y, Poon V, Sanchez-Watts G, Watts AG, Takemori H, Aguilera G. Salt-inducible kinase is involved in the regulation of corticotropin-releasing hormone transcription in hypothalamic neurons in rats. Endocrinology 2012; 153: 223-233.
37. So AY, Chaivorapol C, Bolton EC, Li H, Yamamoto KR. Determinants of cell- and gene-specific transcriptional regulation by the glucocorticoid receptor. PLoS Genet 2007; 3: e94.
38. Hakim O, John S, Ling JQ, Biddie SC, Hoffman AR, Hager GL. Glucocorticoid receptor activation of the Ciz1-Lcn2 locus by long range interactions. J Biol Chem 2009; 284: 6048-6052.
39. Paakinaho V, Makkonen H, Jääskeläinen T, Palvimo JJ. Glucocorticoid receptor activates poised FKBP51 locus through long-distance interactions. Mol Endocrinol 2010; 24: 511-525.
40. Liu Y, Coello AG, Grinevich V, Aguilera G. Involvement of transducer of regulated cAMP response element-binding protein activity on corticotropin releasing hormone transcription. Endocrinology 2010; 151: 1109-1118.
41. Liu Y, Knobloch HS, Grinevich V, Aguilera G. Stress induces nuclear translocation of the CREB co-activator, transducer of regulated CREB activity (TORC) in corticotropin releasing hormone neurons. J Neuroendocrinol 2011; 23: 216-223.
42. Jeanneteau FD, Lambert WM, Ismaili N, Bath KG, Lee FS, Garabedian MJ, Chao MV. BDNF and glucocorticoids regulate corticotrophin-releasing hormone (CRH) homeostasis in the hypothalamus. Proc Natl Acad Sci 2012; 109: 1305-1310.
43. Adler GK, Smas CM, Majzoub JA. Expression and dexamethasone regulation of the human corticotropin-releasing hormone gene in a mouse anterior pituitary cell line. J Biol Chem 1988; 263: 5846-5852.
44. Kageyama K, Akimoto K, Suda T. Corticotrophin-releasing factor gene transcription is directly activated after deprivation of glucocorticoids in hypothalamic cells. J Neuroendocrinol 2010; 22: 971-978.
45. Dallman MF, Yates FE. Dynamic asymmetries in the corticosteroid feedback path and distribution-metabolism-binding elements of the adrenocortical system. Ann N Y Acad Sci 1969; 156: 696-721.
46. Di S, Malcher-Lopes R, Halmos KC, Tasker JG. Nongenomic glucocorticoid inhibition via endocannabinoid release in the hypothalamus: a fast feedback mechanism. J Neurosci 2003; 23: 4850-4857.
47. Malcher-Lopes R, Di S, Marcheselli VS, Weng FJ, Stuart CT, Bazan NG, Tasker JG. Opposing crosstalk between leptin and glucocorticoids rapidly modulates synaptic excitation via endocannabinoid release. J Neurosci 2006; 26: 6643-6650.
48. Patel S, Roelke CT, Rademacher DJ, Cullinan WE, Hillard CJ. Endocannabinoid signaling negatively modulates stress-induced activation of the hypothalamic-pituitary-adrenal axis. Endocrinology 2004; 145: 5431-5438.
49. Cota D, Steiner MA, Marsicano G, Cervino C, Herman JP, Grubler Y, Stalla J, Pasquali R, Lutz B, Stalla GK, Pagotto U. Requirement of cannabinoid receptor type 1 for the basal modulation of hypothalamic-pituitary-adrenal axis function. Endocrinology 2007; 148: 1574-1581.
50. Ginsberg AB, Pecoraro NC, Warne JP, Horneman HF, Dallman MF. Rapid alteration of stress-induced hypothalamic-pituitary-adrenal hormone secretion in the rat: a comparison of glucocorticoids and cannabinoids. Stress 2010; 13: 248-257.
51. Hill MN, McEwen BS. Involvement of the endocannabinoid system in the neurobehavioural effects of stress and glucocorticoids. Prog Neuropsychopharmacol Biol Psychiatry 2010; 34: 791-797.
52. Evanson NK, Tasker JG, Hill MN, Hillard CJ, Herman JP. Fast feedback inhibition of the HPA axis by glucocorticoids is mediated by endocannabinoid signaling. Endocrinology 2010; 151: 4811-4819.
53. Hamm J, Halmos KC, Muglia LJ, Tasker JG. Rapid synaptic modulation of hypothalamic neurons by glucocorticoids requires the glucocorticoid receptor. 2010 Neuroscience Meeting Planner. San Diego, CA: Society for Neuroscience, 2010; Program No. 389.19.
54. Johnson LR, Farb C, Morrison JH, McEwen BS, LeDoux JE. Localization of glucocorticoid receptors at postsynaptic membranes in the lateral amygdala. Neuroscience 2005; 136: 289-299.
55. Komatsuzaki Y, Murakami G, Tsurugizawa T, Mukai H, Tanabe N, Mitsuhashi K, Kawata M, Kimoto T, Ooishi Y, Kawato S. Rapid spinogenesis of pyramidal neurons induced by activation of glucocorticoid receptors in adult male rat hippocampus. Biochem Biophys Res Commun 2005; 335: 1002-1007.
56. Wang CC, Wang SJ. Modulation of presynaptic glucocorticoid receptors on glutamate release from rat hippocampal nerve terminals. Synapse 2009; 63: 745-751.
57. Prager EM, Brielmaier J, Bergstrom HC, McGuire J, Johnson LR. Localization of mineralocorticoid receptors at mammalian synapses. PLoS One 2010; 5: e14344.
58. Cunningham ET Jr, Sawchenko PE. Anatomical specificity of noradrenergic inputs to the paraventricular and supraoptic nuclei of the rat hypothalamus. J Comp Neurol 1988; 274: 60-76.
59. Cunningham ET Jr, Bohn MC, Sawchenko PE. Organization of adrenergic inputs to the paraventricular and supraoptic nuclei of the hypothalamus in the rat. J Comp Neurol 1990; 292: 651-667.
60. Pacak K, Palkovits M, Kopin IJ, Goldstein DS. Stress-induced norepinephrine release in the hypothalamic paraventricular nucleus and pituitary-adrenocortical and sympathoadrenal activity: in vivo microdialysis studies. Front Neuroendocrinol 1995; 16: 89-150.
61. Szafarczyk A, Malaval F, Laurent A, Gibaud R, Assenmacher I. Further evidence for a central stimulatory action of catecholamines on adrenocorticotropin release in the rat. Endocrinology 1987; 121: 883-892.
62. Itoi K, Suda T, Tozawa F, Dobashi I, Ohmori N, Sakai Y, Abe K, Demura H. Microinjection of norepinephrine into the paraventricular nucleus of the hypothalamus stimulates corticotropin-releasing factor gene expression in conscious rats. Endocrinology 1994; 135: 2177-2182.
63. Sarkar S, Fekete C, Legradi G, Lechan RM. Glucagon like peptide-1 (7-36) amide (GLP-1) nerve terminals densely innervate corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Brain Res 2003; 985: 163-168.
64. Tauchi M, Zhang R, D'Alessio DA, Stern JE, Herman JP. Distribution of glucagon-like peptide-1 immunoreactivity in the hypothalamic paraventricular and supraoptic nuclei. J Chem Neuroanat 2008a; 36: 144-149.
65. Kinzig KP, D'Alessio DA, Herman JP, Sakai RR, Vahl TP, Figueiredo HF, Murphy EK, Seeley RJ. CNS glucagon-like peptide-1 receptors mediate endocrine and anxiety responses to interoceptive and psychogenic stressors. J Neurosci 2003; 23: 6163-6170.
66. Tauchi M, Zhang R, D'Alessio DA, Seeley RJ, Herman JP. Role of central glucagon-like peptide-1 in hypothalamo-pituitary-adrenocortical facilitation following chronic stress. Exp Neurol 2008b; 210: 458-466.
67. Zhang R, Packard BA, Tauchi M, D'Alessio DA, Herman JP. Glucocorticoid regulation of preproglucagon transcription and RNA stability during stress. Proc Natl Acad Sci USA 2009; 106: 5913-5918.
68. Fossom LH, Sterling CR, Tank AW. Regulation of tyrosine hydroxylase gene transcription rate and tyrosine hydroxylase mRNA stability by cyclic AMP and glucocorticoid. Mol Pharmacol 1992; 42: 898-908.
69. Dhawan L, Liu B, Blaxall BC, Taubman MB. A novel role for the glucocorticoid receptor in the regulation of monocyte chemoattractant protein-1 mRNA stability. J Biol Chem 2007; 282: 10146-10152.
70. Keller-Wood M, Dallman MF. Corticosteroid inhibition of ACTH secretion. Endocr Rev 1984; 5: 1-24.
71. Laugero KD, Bell ME, Bhatnagar S, Soriano L, Dallman MF. Sucrose ingestion normalizes central expression of corticotropin-releasing-factor messenger ribonucleic acid and energy balance in adrenalectomized rats: a glucocorticoid-metabolic-brain axis? Endocrinology 2001; 142: 2796-2804.
72. Dallman MF, Akana SF, Laugero KD, Gomez F, Manalo S, Bell ME, Bhatnagar S. A spoonful of sugar: feedback signals of energy stores and corticosterone regulate responses to chronic stress. Physiol Behav 2003; 79: 3-12.
73. la Fleur SE, Houshyar H, Roy M, Dallman MF. Choice of lard, but not total lard calories, damps adrenocorticotropin responses to restraint. Endocrinology 2005; 146: 2193-2199.
74. Campbell JE, Peckett AJ, D'Souza AM, Hawke TJ, Riddell MC. Adipogenic and lipolytic effects of chronic glucocorticoid exposure. Am J Physiol Cell Physiol 2011; 300: C198-C209.
75. Oh YT, Oh KS, Kang I, Youn JH. A fall in plasma free fatty acid (FFA) level activates the hypothalamic-pituitary-adrenal axis independent of plasma glucose: evidence for brain sensing of circulating FFA. Endocrinology 2012; 153: 3587-3592.
76. Oh YT, Kim J, Kang I, Youn JH. Regulation of hypothalamic-pituitary-adrenal axis by circulating free fatty acids in male Wistar rats: role of individual free fatty acids. Endocrinology 2014; 155: 923-931.
77. Sarruf DA, Yu F, Nguyen HT, Williams DL, Printz RL, Niswender KD, Schwartz MW. Expression of peroxisome proliferator-activated receptor-gamma in key neuronal subsets regulating glucose metabolism and energy homeostasis. Endocrinology 2009; 150: 707-712.
78. Ryan KK, Grayson BE, Jones KR, Schneider AL, Woods SC, Seeley RJ, Herman JP, Ulrich-Lai YM. Physiological responses to acute psychological stress are reduced by the PPARgamma agonist rosiglitazone. Endocrinology 2012; 153: 1279-1287.
79. Ulrich-Lai YM, Herman JP. Neural regulation of endocrine and autonomic stress responses. Nat Rev Neurosci 2009; 10: 397-409.
80. Buckingham JC, John CD, Solito E, Tierney T, Flower RJ, Christian H, Morris J. Annexin 1, glucocorticoids, and the neuroendocrine-immune interface. Ann N Y Acad Sci 2006; 1088: 396-409.
81. Jasper MS, Engeland WC. Splanchnicotomy increases adrenal sensitivity to ACTH in nonstressed rats. Am J Physiol 1997; 273: E363-E368.
82. Joels M, Baram TZ. The neuro-symphony of stress. Nat Rev Neurosci 2009; 10: 459-466.
83. McEwen BS. Physiology and neurobiology of stress and adaptation: central role of the brain. Physiol Rev 2007; 87: 873-904.
84. Bravo JA, Parra CS, Arancibia S, Andres S, Morales P, Herrera-Marschitz M, Herrera L, Lara HE, Fiedler JL. Adrenalectomy promotes a permanent decrease of plasma corticoid levels and a transient increase of apoptosis and the expression of transforming growth factor beta1 (TGF-beta1) in hippocampus: effect of a TGF-beta1 oligo-antisense. BMC Neurosci 2006; 7: 40.
85. Greiner M, Cardenas S, Parra C, Bravo J, Avalos AM, Paredes A, Lara HE, Fiedler JL. Adrenalectomy regulates apoptotic-associated genes in rat hippocampus. Endocrine 2001; 15: 323-333.
86. Sloviter RS, Sollas AL, Dean E, Neubort S. Adrenalectomy-induced granule cell degeneration in the rat hippocampal dentate gyrus: characterization of an in vivo model of controlled neuronal death. J Comp Neurol 1993; 330: 324-336.
87. Sloviter RS, Valiquette G, Abrams GM, Ronk EC, Sollas AL, Paul LA, Neubort S. Selective loss of hippocampal granule cells in the mature rat brain after adrenalectomy. Science 1989; 243: 535-538.
88. Woolley CS, Gould E, Sakai RR, Spencer RL, McEwen BS. Effects of aldosterone or RU28362 treatment on adrenalectomy-induced cell death in the dentate gyrus of the adult rat. Brain Res 1991; 554: 312-315.
89. Cardenas SP, Parra C, Bravo J, Morales P, Lara HE, Herrera-Marschitz M, Fiedler JL. Corticosterone differentially regulates bax, bcl-2 and bcl-x mRNA levels in the rat hippocampus. Neurosci Lett 2002; 331: 9-12.
90. Andres S, Cardenas S, Parra C, Bravo J, Greiner M, Rojas P, Morales P, Lara H, Fiedler J. Effects of long-term adrenalectomy on apoptosis and neuroprotection in the rat hippocampus. Endocrine 2006; 29: 299-308.
91. Cameron HA, Gould E. Adult neurogenesis is regulated by adrenal steroids in the dentate gyrus. Neuroscience 1994; 61: 203-209.
92. Joels M, Pu Z, Wiegert O, Oitzl MS, Krugers HJ. Learning under stress: how does it work? Trends Cogn Sci 2006; 10: 152-158.
93. Bagley J, Moghaddam B. Temporal dynamics of glutamate efflux in the prefrontal cortex and in the hippocampus following repeated stress: effects of pretreatment with saline or diazepam. Neuroscience 1997; 77: 65-73.
94. Musazzi L, Milanese M, Farisello P, Zappettini S, Tardito D, Barbiero VS, Bonifacino T, Mallei A, Baldelli P, Racagni G, Raiteri M, Benfenati F, Bonanno G, Popoli M. Acute stress increases depolarization-evoked glutamate release in the rat prefrontal/frontal cortex: the dampening action of antidepressants. PLoS One 2010; 5: e8566.
95. Reznikov LR, Grillo CA, Piroli GG, Pasumarthi RK, Reagan LP, Fadel J. Acute stress-mediated increases in extracellular glutamate levels in the rat amygdala: differential effects of antidepressant treatment. Eur J Neurosci 2007; 25: 3109-3114.
96. Moghaddam B, Bolinao ML, Stein-Behrens B, Sapolsky R. Glucocorticoids mediate the stress-induced extracellular accumulation of glutamate. Brain Res 1994; 655: 251-254.
97. Venero C, Borrell J. Rapid glucocorticoid effects on excitatory amino acid levels in the hippocampus: a microdialysis study in freely moving rats. Eur J Neurosci 1999; 11: 2465-2473.
98. Karst H, Joels M. Corticosterone slowly enhances miniature excitatory postsynaptic current amplitude in mice CA1 hippocampal cells. J Neurophysiol 2005; 94: 3479-3486.
99. Karst H, Berger S, Turiault M, Tronche F, Schutz G, Joels M. Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by corticosterone. Proc Natl Acad Sci USA 2005; 102: 19204-19207.
100. Liston C, Cichon JM, Jeanneteau F, Jia Z, Chao MV, Gan WB. Circadian glucocorticoid oscillations promote learning-dependent synapse formation and maintenance. Nat Neurosci 2013; 16: 698-705.
101. Shors TJ, Chua C, Falduto J. Sex differences and opposite effects of stress on dendritic spine density in the male versus female hippocampus. J Neurosci 2001; 21: 6292-6297.
102. Komatsuzaki Y, Hatanaka Y, Murakami G, Mukai H, Hojo Y, Saito M, Kimoto T, Kawato S. Corticosterone induces rapid spinogenesis via synaptic glucocorticoid receptors and kinase networks in hippocampus. PLoS One 2012; 7: e34124.
103. Jafari M, Seese RR, Babayan AH, Gall CM, Lauterborn JC. Glucocorticoid receptors are localized to dendritic spines and influence local actin signaling. Mol Neurobiol 2012; 46: 304-315.
104. Miyashiro KY, Beckel-Mitchener A, Purk TP, Becker KG, Barret T, Liu L, Carbonetto S, Weiler IJ, Greenough WT, Eberwine J. RNA cargoes associating with FMRP reveal deficits in cellular functioning in Fmr1 null mice. Neuron 2003; 37: 417-431.
105. Sidorov MS, Auerbach BD, Bear MF. Fragile X mental retardation protein and synaptic plasticity. Mol Brain 2013; 6: 15.
106. Martin S, Henley JM, Holman D, Zhou M, Wiegert O, van Spronsen M, Joels M, Hoogenraad CC, Krugers HJ. Corticosterone alters AMPAR mobility and facilitates bidirectional synaptic plasticity. PLoS One 2009; 4: e4714.
107. Conboy L, Sandi C. Stress at learning facilitates memory formation by regulating AMPA receptor trafficking through a glucocorticoid action. Neuropsychopharmacology 2010; 35: 674-685.
108. Bramham CR, Worley PF, Moore MJ, Guzowski JF. The immediate early gene arc/arg3.1: regulation, mechanisms, and function. J Neurosci 2008; 28: 11760-11767.
109. Guzowski JF, Lyford GL, Stevenson GD, Houston FP, McGaugh JL, Worley PF, Barnes CA. Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J Neurosci 2000; 20: 3993-4001.
110. Rial Verde EM, Lee-Osbourne J, Worley PF, Malinow R, Cline HT. Increased expression of the immediate-early gene arc/arg3.1 reduces AMPA receptor-mediated synaptic transmission. Neuron 2006; 52: 461-474.
111. Shepherd JD, Bear MF. New views of Arc, a master regulator of synaptic plasticity. Nat Neurosci 2011; 14: 279-284.
112. Schwartz MW, Woods SC, Porte JRD, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000; 404: 661-671.
113. Gehlert DR. Role of hypothalamic neuropeptide Y in feeding and obesity. Neuropeptides 1999; 33: 329-338.
114. Smith PM, Ferguson AV. Neurophysiology of hunger and satiety. Dev Disabil Res Rev 2008; 14: 96-104.
115. Valassi E, Scacchi M, Cavagnini F. Neuroendocrine control of food intake. Nutr Metab Cardiovasc Dis 2008; 18: 158-168.
116. Havel PJ. Peripheral signals conveying metabolic information to the brain: short-term and long-term regulation of food intake and energy homeostasis. Exp Biol Med 2001; 226: 963-977.
117. La Fleur SE. The effects of glucocorticoids on feeding behavior in rats. Physiol Behav 2006; 89: 110-114.
118. Leal AM, Moreira AC. Food and the circadian activity of the hypothalamic-pituitary-adrenal axis. Braz J Med Biol Res 1997; 30: 1391-1405.
119. Honma KI, Honma S, Hiroshige T. Critical role of food amount for prefeeding corticosterone peak in rats. Am J Physiol 1983; 245: R339-R344.
120. Tataranni PA, Larson DE, Snitker S, Young JB, Flatt JP, Ravussin E. Effects of glucocorticoids on energy metabolism and food intake in humans. Am J Physiol 1996; 271: E317-E325.
121. Nieuwenhuizen AG, Rutters F. The hypothalamic-pituitary-adrenal-axis in the regulation of energy balance. Physiol Behav 2008; 94: 169-177.
122. Shibli-Rahhal A, Van Beek M, Schlechte JA. Cushing's syndrome. Clin Dermatol 2006; 24: 260-265.
123. Nieman LK, Chanco Turner ML. Addison's disease. Clin Dermatol 2006; 24: 276-280.
124. Devenport L, Knehans A, Sundstrom A, Thomas T. Corticosterone's dual metabolic actions. Life Sci 1989; 45: 1389-1396.
125. Tempel DL, Leibowitz SF. PVN steroid implants: effect on feeding patterns and macronutrient selection. Brain Res Bull 1989; 23: 553-560.
126. Tempel DL, McEwen BS, Leibowitz SF. Adrenal steroid receptors in the PVN: studies with steroid antagonists in relation to macronutrient intake. Neuroendocrinology 1993; 57: 1106-1113.
127. Tempel DL, Leibowitz SF. Adrenal steroid receptors: interactions with brain neuropeptide systems in relation to nutrient intake and metabolism. J Neuroendocrinol 1994; 6: 479-501.
128. Kumar BA, Leibowitz SF. Impact of acute corticosterone administration on feeding and macronutrient self-selection patterns. Am J Physiol 1988; 254: R222-R228.
129. Kumar BA, Papamichael M, Leibowitz SF. Feeding and macronutrient selection patterns in rats: adrenalectomy and chronic corticosterone replacement. Physiol Behav 1988; 42: 581-589.
130. Goldstein RE, Wasserman DH, McGuinness OP, Lacy DB, Cherrington AD, Abumrad NN. Effects of chronic elevation in plasma cortisol on hepatic carbohydrate metabolism. Am J Physiol 1993; 264: E119-E127.
131. Tomas FM, Munro HN, Young VR. Effect of glucocorticoid administration on the rate of muscle protein breakdown in vivo in rats, as measured by urinary excretion of N tau-methylhistidine. Biochem J 1979; 178: 139-146.
132. Cusin I, Rouru J, Rohner-Jeanrenaud F. Intracerebroventricular glucocorticoid infusion in normal rats: induction of parasympathetic-mediated obesity and insulin resistance. Obes Res 2001; 9: 401-406.
133. Zakrzewska KE, Cusin I, Stricker-Krongrad A, Boss O, Ricquier D, Jeanrenaud B, Rohner-Jeanrenaud F. Induction of obesity and hyperleptinemia by central glucocorticoid infusion in the rat. Diabetes 1999; 48: 365-370.
134. Aronsson M, Fuxe K, Dong Y, Agnati LF, Okret S, Gustafsson JA. Localization of glucocorticoid receptor mRNA in the male rat brain by in situ hybridization. Proc Natl Acad Sci USA 1988; 85: 9331-9335.
135. Hisano S, Kagotani Y, Tsuruo Y, Daikoku S, Chihara K, Whitnall MH. Localization of glucocorticoid receptor in neuropeptide Y-containing neurons in the arcuate nucleus of the rat hypothalamus. Neurosci Lett 1988; 95: 13-18.
136. Uchoa ET, Silva LE, de Castro M, Antunes-Rodrigues J, Elias LL. Glucocorticoids are required for meal-induced changes in the expression of hypothalamic neuropeptides. Neuropeptides 2012; 46: 119-124.
137. Freedman MR, Castonguay TW, Stern JS. Effect of adrenalectomy and corticosterone replacement on meal patterns of Zucker rats. Am J Physiol 1985; 249: R584-R594.
138. Uchoa ET, Sabino HA, Ruginsk SG, Antunes-Rodrigues J, Elias LL. Hypophagia induced by glucocorticoid deficiency is associated with an increased activation of satiety-related responses. J Appl Physiol 2009; 106: 596-604.
139. Uchoa ET, Silva LE, de Castro M, Antunes-Rodrigues J, Elias LL. Hypothalamic oxytocin neurons modulate hypophagic effect induced by adrenalectomy. Horm Behav 2009; 56: 532-538.
140. Uchoa ET, Silva LE, de Castro M, Antunes-Rodrigues J, Elias LL. Corticotrophin-releasing factor mediates hypophagia after adrenalectomy, increasing meal-related satiety responses. Horm Behav 2010; 58: 714-719.
141. Bruce BK, King BM, Phelps GR, Veitia MC. Effects of adrenalectomy and corticosterone administration on hypothalamic obesity in rats. Am J Physiol 1982; 243: E152-E157.
142. Dubuc PU, Wilden NJ. Adrenalectomy reduces but does not reverse obesity in ob/ob mice. Int J Obes 1986; 10: 91-98.
143. Yukimura Y, Bray GA, Wolfsen AR. Some effects of adrenalectomy in the fatty rat. Endocrinology 1978; 103: 1924-1928.
144. Germano CM, Castro M, Rorato R, Laguna MT, Antunes-Rodrigues J, Elias CF, Elias LL. Time course effects of adrenalectomy and food intake on cocaine- and amphetamine-regulated transcript expression in the hypothalamus. Brain Res 2007; 1166: 55-64.
145. Uchoa ET, Zahm DS, de Carvalho Borges B, Rorato R, Antunes-Rodrigues J, Elias LL. Oxytocin projections to the nucleus of the solitary tract contribute to the increased meal-related satiety responses in primary adrenal insufficiency. Exp Physiol 2013; 98: 1495-1504.
146. Deak T, Bordner K, McElderry N, Barnum C, Blandino P Jr, Deak M, Tammariello S. Stress-induced increases in hypothalamic IL-1: a systematic analysis of multiple stressor paradigms. Brain Res Bull 2005; 64: 541-556.
147. Hueston CM, Barnum CJ, Eberle JA, Ferraioli FJ, Buck HM, Deak T. Stress-dependent changes in neuroinflammatory markers observed after common laboratory stressors are not seen following acute social defeat of the Sprague Dawley rat. Physiol Behav 2011; 104: 187-198.
148. Hueston CM, Buck HM, Deak T. The inflamed axis: the interaction between cytokines and HPA hormones in the stress response. Physiol Behav 2014; 124: 77-91.
149. Garcia-Bueno B, Madrigal JL, Perez-Nievas BG, Leza JC. Stress mediators regulate brain prostaglandin synthesis and peroxisome proliferator-activated receptor-gamma activation after stress in rats. Endocrinology 2008; 149: 1969-1978.
150. Frank MG, Baratta MV, Sprunger DB, Watkins LR, Maier SF. Microglia serve as a neuroimmune substrate for stress-induced potentiation of CNS pro-inflammatory cytokine responses. Brain Behav Immun 2007; 21: 47-59.
151. Nair A, Bonneau RH. Stress-induced elevation of glucocorticoids increases microglia proliferation through NMDA receptor activation. J Neuroimmunol 2006; 171: 72-85.
152. Blandino P Jr, Barnum CJ, Solomon LG, Larish Y, Lankow BS, Deak T. Gene expression changes in the hypothalamus provide evidence for regionally-selective changes in IL-1 and microglial markers after acute stress. Brain Behav Immun 2009; 23: 958-968.
153. Sugama S, Fujita M, Hashimoto M, Conti B. Stress induced morphological microglial activation in the rodent brain: involvement of interleukin-18. Neuroscience 2007; 146: 1388-1399.
154. Blandino P Jr, Barnum CJ, Deak T. The involvement of norepinephrine and microglia in hypothalamic and splenic IL-1beta responses to stress. J Neuroimmunol 2006; 173: 87-95.
155. Johnson JD, Campisi J, Sharkey CM, Kennedy SL, Nickerson M, Greenwood BN, Fleshner M. Catecholamines mediate stress-induced increases in peripheral and central inflammatory cytokines. Neuroscience 2005; 135: 1295-1307.
156. Blandino P Jr, Hueston CM, Barnum CJ, Bishop C, Deak T. The impact of ventral noradrenergic bundle lesions on increased IL-1 in the PVN and hormonal responses to stress in male sprague dawley rats. Endocrinology 2013; 154: 2489-2500.
157. Porterfield VM, Zimomra ZR, Caldwell EA, Camp RM, Gabella KM, Johnson JD. Rat strain differences in restraint stress-induced brain cytokines. Neuroscience 2011; 188: 48-54.
158. Windle RJ, Wood SA, Lightman SL, Ingram CD. The pulsatile characteristics of hypothalamo-pituitary-adrenal activity in female Lewis and Fischer 344 rats and its relationship to differential stress responses. Endocrinology 1998; 139: 4044-4052.
159. Maslanik T, Mahaffey L, Tannura K, Beninson L, Greenwood BN, Fleshner M. The inflammasome and danger associated molecular patterns (DAMPs) are implicated in cytokine and chemokine responses following stressor exposure. Brain Behav Immun 2013; 28: 54-62.
160. Nguyen K, Deak T, Owens S, Kohno T, Fleshner M, Watkins L, Maier S. Exposure ot acute stress induces brain interleukin-1 beta protein in the rat. J Neurosci 1998; 18: 2239-2246.
161. Nguyen KT, Deak T, Will MJ, Hansen MK, Hunsaker BN, Fleshner M, Watkins LR, Maier SF. Timecourse and corticosterone sensitivity of the brain, pituitary, and serum interleukin-1b protein response to acute stress. Brain Res 2000; 859: 193-201.
162. Busillo JM, Cidlowski JA. The five Rs of glucocorticoid action during inflammation: ready, reinforce, repress, resolve, and restore. Trends Endocrinol Metab 2013; 24: 109-119.
163. Necela BM, Cidlowski JA. Mechanisms of glucocorticoid receptor action in noninflammatory and inflammatory cells. Proc Am Thorac Soc 2004; 1: 239-246.
164. Watkins LR, Hansen MK, Nguyen KT, Lee JE, Maier SF. Dynamic regulation of the proinflammatory cytokine interleukin-1b: molecular biology for non-molecular biologists. Life Sci 1999; 65: 449-481.
165. Frank MG, Watkins LR, Maier SF. Stress-induced glucocorticoids as a neuroendocrine alarm signal of danger. Brain Behav Immun 2013; 33: 1-6.
166. Sorrells SF, Sapolsky RM. An inflammatory review of glucocorticoid actions in the CNS. Brain Behav Immun 2007; 21: 259-272.
167. Goshen I, Kreisel T, Ben-Menachem-Zidon O, Licht T, Weidenfeld J, Ben-Hur T, Yirmiya R. Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression. Mol Psychiatry 2008; 13: 717-728.
168. Johnson JD, O'Connor KA, Watkins LR, Maier SF. The role of IL-1beta in stress-induced sensitization of proinflammatory cytokine and corticosterone responses. Neuroscience 2004; 127: 569-577.
169. Bornstein SR, KZiegler CG, Krug AW, Kanczkowski W, Rettori V, McCann SM, Wirth M, Zacharowski K. The role of toll-like receptors in the immune-adrenal crosstalk. Ann N Y Acad Sci 2006; 1088: 307-318.
170. Deak T. From classic aspects of the stress response to neuroinflammation and sickness: implications for individuals and offspring of diverse species. Int J Comp Psychol 2007; 20: 96-110.
171. Engstrom L, Rosen K, Angel A, Fyrberg A, Mackerlova L, Konsman JP, Engblom D, Blomqvist A. Systemic immune challenge activates an intrinsically regulated local inflammatory circuit in the adrenal gland. Endocrinology 2008; 19: 1436-14350.
172. Mazzocchi G, Gottardo G, Nussdorfer GG. A local immuno-endocrine interaction may mediate rat adrenal glucocorticoid response to bacterial endotoxins. Life Sci 1998; 62: 1783-1787.
173. Beishuizen A, Thijs LG, Haanen C, Vermes I. Macrophage migration inhibitory factor and hypothalamo-pituitary-adrenal function during critical illness. J Clin Endocrinol Metab 2001; 86: 2811-2816.
174. Vermes I, Beishuizen A, Hampsink RM, Haanen C. Dissociation of plasma adrenocorticotropin and cortisol levels in critically ill patients: possible role of endothelin and atrial natriuretic hormone. J Clin Endocrinol Metab 1995; 80: 1238-1242.
175. Arakawa H, Blandino P Jr, Deak T. Central infusion of interleukin-1 receptor antagonist blocks the reduction in social behavior produced by prior stressor exposure. Physiol Behav 2009; 98: 139-146.
176. Koo JW, Duman RS. Interleukin-1 receptor null mutant mice show decreased anxiety-like behavior and enhanced fear memory. Neurosci Lett 2009; 456: 39-43.
177. Pugh CR, Nguyen KT, Gonyea JL, Fleshner M, Watkins LR, Maier SF, Rudy JW. Role of interleukin-1 beta in impairment of contextual fear conditioning caused by social isolation. Behav Brain Res 1999; 106: 109-118.
178. Maier SF, Watkins LR. Intracerebroventricular interleukin-1 receptor antagonist blocks the enhancement of fear conditioning and interference with escape produced by inescapable shock. Brain Res 1995; 695: 279-282.
179. Barnum CJ, Tansey MG. Neuroinflammation and non-motor symptoms: the dark passenger of Parkinson's disease? Curr Neurol Neurosci Rep 2012; 12: 350-358.
180. Deak T. From hippocampus to dorsal horn: the pervasive impact of IL-1 on learning and memory spans the length of the neuroaxis. Brain Behav Immun 2007; 21: 746-747.
181. Wager-Smith K, Markou A. Depression: a repair response to stress-induced neuronal microdamage that can grade into a chronic neuroinflammatory condition? Neurosci Biobehav Rev 2011; 35: 742-764.