Melanocortin MC4 receptor expression sites and local function

European Journal of Pharmacology

Volumn 660, Issue 1, 2011, Pages 234-240

  Siljee Wong, Jacqueline E ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

MSH; (Mouse); (Rat); Brain; Expression; Human; MC4R; Melanocortin; Melanocortin MC4 receptor; Melanotan II

Indexed keywords

ALPHA INTERMEDIN; MELANOCORTIN 4 RECEPTOR; MELANOTAN II; MESSENGER RNA;

AMYGDALOID NUCLEUS; BRAIN CORTEX; BRAIN STEM; CORPUS STRIATUM; DENTATE HILUS; ENERGY METABOLISM; FOOD INTAKE; FOREBRAIN; HIPPOCAMPAL CA3 REGION; HORMONAL REGULATION; HUMAN; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS; LIGAND BINDING; NAUSEA; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REVIEW; SEPTUM NUCLEUS; SPINAL CORD; THALAMUS; ANIMAL; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; PROTEIN TRANSPORT;

ANIMALS; BRAIN STEM; GENE EXPRESSION REGULATION; HUMANS; PROSENCEPHALON; PROTEIN TRANSPORT; RECEPTOR, MELANOCORTIN, TYPE 4; SPINAL CORD;

EID: 79955941603     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.10.104     Document Type: Review

References (54)

1. Adan, R.A., Szklarczyk, A.W., Oosterom, J., Brakkee, J.H., Nijenhuis, W.A., Schaaper, W.M., Meloen, R.H., Gispen, W.H., 1999. Characterization of melanocortin receptor ligands on cloned brain melanocortin receptors and on grooming behavior in the rat. Eur. J. Pharmacol. 378, 249-258.
2. Argiolas, A., Melis, M.R., Murgia, S., Schioth, H.B., 2000. Brain Res. Bull. 51, 425-431.
3. Balthasar, N., Dalgaard, L.T., Lee, C.E., Yu, J., Funahashi, H., Williams, T., Ferreira, M., Tang, V., McGovern, R.A., Kenny, C.D., Christiansen, L.M., Edelstein, E., Choi, B., Boss, O., Aschkenasi, C., Zhang, C.Y., Mountjoy, K., Kishi, T., Elmquist, J.K., Lowell, B.B., 2005. Divergence of melanocortin pathways in the control of food intake and energy expenditure. Cell 123, 493-505. (Pubitemid 41546678)
4. Bertolini, A., Tacchi, R., Vergoni, A.V., 2009. Brain effects of melanocortins. Pharmacol. Res. 59, 13-47.
5. Boghossian, S., Park, M., York, D.A., 2010. Melanocortin activity in the amygdala controls appetite for dietary fat. Am. J. Physiol. Regul. Integr. Comp. Physiol. 298, R385-R393.
6. Bressers, W.M., Kruk, M.R., Van Erp, A.M., Willekens-Bramer, D.C., Haccou, P., Meelis, E., 1995. A time-structured analysis of hypothalamically induced increases in self-grooming and activity in the rat. Behav. Neurosci. 109, 1158-1171.
7. Chhajlani, V., 1996. Distribution of cDNA for melanocortin receptor subtypes in human tissues. Biochem. Mol. Biol. Int. 38, 73-80.
8. Cowley, M.A., Pronchuk, N., Fan, W., Dinulescu, D.M., Colmers, W.F., Cone, R.D., 1999. Integration of NPY, AGRP, and melanocortin signals in the hypothalamic paraventricular nucleus: evidence of a cellular basis for the adipostat. Neuron 24, 155-163. (Pubitemid 29466155)
9. Daniel, P.B., Fernando, C., Wu, C.S., Marnane, R., Broadhurst, R., Mountjoy, K.G., 2005. 1 kb of 5′ flanking sequence from mouse MC4R gene is sufficient for tissue specific expression in a transgenic mouse. Mol. Cell. Endocrinol. 239, 63-71.
10. De Souza, J., Butler, A.A., Cone, R.D., 2000. Disproportionate inhibition of feeding in A(y) mice by certain stressors: a cautionary note. Neuroendocrinology 72, 126-132.
11. De Wied, D., 1966. Inhibitory effect of ACTH and related peptides on extinction of conditioned avoidance behavior in rats. Proc. Soc. Exp. Biol. Med. 122, 28-32.
12. Decherf, S., Seugnet, I., Kouidhi, S., Lopez-Juarez, A., Clerget-Froidevaux, M.S., Demeneix, B.A., 2010. Thyroid hormone exerts negative feedback on hypothalamic type 4 melanocortin receptor expression. Proc. Natl. Acad. Sci. U. S. A. 107, 4471-4476.
13. Ellis, C., Moar, K.M., Logie, T.J., Ross, A.W., Morgan, P.J., Mercer, J.G., 2008. Diurnal profiles of hypothalamic energy balance gene expression with photoperiod manipulation in the Siberian hamster, Phodopus sungorus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294, R1148-R1153.
14. Farooqi, I.S., Yeo, G.S., Keogh, J.M., Aminian, S., Jebb, S.A., Butler, G., Cheetham, T., O'Rahilly, S., 2000. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J. Clin. Invest. 106, 271-279.
15. Farooqi, I.S., Keogh, J.M., Yeo, G.S., Lank, E.J., Cheetham, T., O'Rahilly, S., 2003. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N. Engl. J. Med. 348, 1085-1095.
16. Gantz, I., Miwa, H., Konda, Y., Shimoto, Y., Tashiro, T., Watson, S.J., DelValle, J., Yamada, T., 1993. Molecular cloning, expression, and gene localization of a fourth melanocortin receptor. J. Biol. Chem. 268, 15174-15179.
17. Garza, J.C., Kim, C.S., Liu, J., Zhang, W., Lu, X.Y., 2008. Adeno-associated virus-mediated knockdown of melanocortin-4 receptor in the paraventricular nucleus of the hypothalamus promotes high-fat diet-induced hyperphagia and obesity. J. Endocrinol. 197, 471-482. (Pubitemid 351803952)
18. Gautron, L., Lee, C., Funahashi, H., Friedman, J., Lee, S., Elmquist, J., 2010. Melanocortin-4 receptor expression in a vago-vagal circuitry involved in postprandial functions. J. Comp. Neurol. 518, 6-24.
19. Germano, C.M., Castro, M., Rorato, R., Costa, D.B., Antunes-Rodrigues, J., Elias, C.F., Elias, L.L., 2008. Downregulation of melanocortin-4 receptor during refeeding and its modulation by adrenalectomy in rats. Horm. Metab. Res. 40, 842-847.
20. Gonzalez, P.V., Schioth, H.B., Lasaga, M., Scimonelli, T.N., 2009. Memory impairment induced by IL-1beta is reversed by alpha-MSH through central melanocortin-4 receptors. Brain Behav. Immun. 23, 817-822.
21. Gout, J., Sarafian, D., Mutel, E., Vigier, M., Rajas, F., Mithieux, G., Begeot, M., Naville, D., 2010. Metabolic and melanocortin gene expression alterations in male offspring of obese mice. Mol. Cell. Endocrinol. 319, 99-108.
22. Greenfield, J.R., Miller, J.W., Keogh, J.M., Henning, E., Satterwhite, J.H., Cameron, G.S., Astruc, B., Mayer, J.P., Brage, S., See, T.C., Lomas, D.J., O'Rahilly, S., Farooqi, I.S., 2009. Modulation of blood pressure by central melanocortinergic pathways. N. Engl. J. Med. 360, 44-52.
23. Grill, H.J., Ginsberg, A.B., Seeley, R.J., Kaplan, J.M., 1998. Brainstem application of melanocortin receptor ligands produces long-lasting effects on feeding and body weight. J. Neurosci. 18, 10128-10135. (Pubitemid 28543786)
24. Hsu, R., Taylor, J.R., Newton, S.S., Alvaro, J.D., Haile, C., Han, G., Hruby, V.J., Nestler, E.J., Duman, R.S., 2005. Blockade of melanocortin transmission inhibits cocaine reward. Eur. J. Neurosci. 21, 2233-2242.
25. Huszar, D., Lynch, C.A., Fairchild-Huntress, V., Dunmore, J.H., Fang, Q., Berkemeier, L.R., Gu, W., Kesterson, R.A., Boston, B.A., Cone, R.D., Smith, F.J., Campfield, L.A., Burn, P., Lee, F., 1997. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 88, 131-141. (Pubitemid 27180337)
26. Jacobowitz, D.M., O'Donohue, T.L., 1978. alpha-Melanocyte stimulating hormone: immunohistochemical identification and mapping in neurons of rat brain. Proc. Natl. Acad. Sci. U. S. A. 75, 6300-6304.
27. Kalsbeek, A., Palm, I.F., La Fleur, S.E., Scheer, F.A., Perreau-Lenz, S., Ruiter, M., Kreier, F., Cailotto, C., Buijs, R.M., 2006. SCN outputs and the hypothalamic balance of life. J. Biol. Rhythms 21, 458-469. (Pubitemid 44706827)
28. Kas, M.J., Tiesjema, B., van Dijk, G., Garner, K.M., Barsh, G.S., ter Beek, O., Verhaagen, J., Adan, R.A., 2004. Induction of brain-region-specific forms of obesity by agouti. J. Neurosci. 24, 10176-10181. (Pubitemid 39492043)
29. Kim, S.M., Rossi, M., Abusnana, S., Sunter, D., Morgan, D.G.A., Small, C.J., Edwards, C.M.B., Heath, M.M., Stanley, S.A., Seal, L.J., Bhatti, J.R., Smith, D.M., Ghatei, M.A., Bloom, S.R., 2000. Hypothalamic localization of the feeding effects of agouti-related peptide and alpha-melanocyte-stimulating hormone. Diabetes 49, 177-182. (Pubitemid 30070994)
30. King, B.M., 2006. Amygdaloid lesion-induced obesity: relation to sexual behavior, olfaction, and the ventromedial hypothalamus. Am. J. Physiol. Regul. Integr. Comp. Physiol. 291, R1201-R1214.
31. Kishi, T., Aschkenasi, C.J., Lee, C.E., Mountjoy, K.G., Saper, C.B., Elmquist, J.K., 2003. Expression of melanocortin 4 receptor mRNA in the central nervous system of the rat. J. Comp. Neurol. 457, 213-235.
32. Kruijver, F.P., Zhou, J.N., Pool, C.W., Hofman, M.A., Gooren, L.J., Swaab, D.F., 2000. Maleto-female transsexuals have female neuron numbers in a limbic nucleus. J. Clin. Endocrinol. Metab. 85, 2034-2041.
33. Lichtensteiger, W., Hanimann, B., Siegrist, W., Eberle, A.N., 1996. Region- and stage-specific patterns of melanocortin receptor ontogeny in rat central nervous system, cranial nerve ganglia and sympathetic ganglia. Brain Res. Dev. Brain Res. 91, 93-110.
34. Liu, H., Kishi, T., Roseberry, A.G., Cai, X., Lee, C.E., Montez, J.M., Friedman, J.M., Elmquist, J.K., 2003. Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J. Neurosci. 23, 7143-7154. (Pubitemid 36975878)
35. Lowry, C.A., 2002. Functional subsets of serotonergic neurones: implications for control of the hypothalamic-pituitary-adrenal axis. J. Neuroendocrinol. 14, 911-923. (Pubitemid 35378709)
36. Mason, H.L., Power, M.H., 1947. Results of administration of anterior pituitary adrenocorticotropic hormone to a human subject. J. Clin. Endocrinol. Metab. 7, 458.
37. Miller, L.H., Kastin, A.J., Sandman, C.A., Fink, M., Van Veen, W.J., 1974. Polypeptide influences on attention, memory and anxiety in man. Pharmacol. Biochem. Behav. 2, 663-668.
38. Mountjoy, K.G., Wild, J.M., 1998. Melanocortin-4 receptor mRNA expression in the developing autonomic and central nervous systems. Brain Res. Dev. Brain Res. 107, 309-314.
39. Mountjoy, K.G., Mortrud, M.T., Low, M.J., Simerly, R.B., Cone, R.D., 1994. Localization of the melanocortin-4 receptor (MC4-R) in neuroendocrine and autonomic control circuits in the brain. Mol. Endocrinol. 8, 1298-1308.
40. Mountjoy, K.G., Jenny Wu, C.S., Dumont, L.M., Wild, J.M., 2003. Melanocortin-4 receptor messenger ribonucleic acid expression in rat cardiorespiratory, musculoskeletal, and integumentary systems. Endocrinology 144, 5488-5496. (Pubitemid 37476078)
41. Oosterom, J., Nijenhuis, W.A., Schaaper, W.M., Slootstra, J., Meloen, R.H., Gispen, W.H., Burbach, J.P., Adan, R.A., 1999. Conformation of the core sequence in melanocortin peptides directs selectivity for the melanocortin MC3 and MC4 receptors. J. Biol. Chem. 274, 16853-16860.
42. Peter, J.C., Nicholson, J.R., Heydet, D., Lecourt, A.C., Hoebeke, J., Hofbauer, K.G., 2007. Antibodies against the melanocortin-4 receptor act as inverse agonists in vitro and in vivo. Am. J. Physiol. Regul. Integr. Comp. Physiol. 292, R2151-R2158.
43. Roselli-Rehfuss, L., Mountjoy, K.G., Robbins, L.S., Mortrud, M.T., Low, M.J., Tatro, J.B., Entwistle, M.L., Simerly, R.B., Cone, R.D., 1993. Identification of a receptor for gamma melanotropin and other proopiomelanocortin peptides in the hypothalamus and limbic system. Proc. Natl. Acad. Sci. U. S. A. 90, 8856-8860.
44. Sayk, F., Heutling, D., Dodt, C., Iwen, K.A., Wellhoner, J.P., Scherag, S., Hinney, A., Hebebrand, J., Lehnert, H., 2010. Sympathetic function in human carriers of melanocortin-4 receptor gene mutations. J. Clin. Endocrinol. Metab. 95, 1998-2002.
45. Ste Marie, L., Miura, G.I., Marsh, D.J., Yagaloff, K., Palmiter, R.D., 2000. A metabolic defect promotes obesity in mice lacking melanocortin-4 receptors. Proc. Natl. Acad. Sci. U. S. A. 97, 12339-12344.
46. Tallam, L.S., Stec, D.E., Willis, M.A., da Silva, A.A., Hall, J.E., 2005. Melanocortin-4 receptor-deficient mice are not hypertensive or salt-sensitive despite obesity, hyperinsulinemia, and hyperleptinemia. Hypertension 46, 326-332. (Pubitemid 41099165)
47. Tallam, L.S., da Silva, A.A., Hall, J.E., 2006. Melanocortin-4 receptor mediates chronic cardiovascular and metabolic actions of leptin. Hypertension 48, 58-64. (Pubitemid 44297525)
48. Vaisse, C., Clement, K., Durand, E., Hercberg, S., Guy-Grand, B., Froguel, P., 2000. Melanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity. J. Clin. Invest. 106, 253-262.
49. Van Boxtel, R., Vroling, B., Toonen, P., Nijman, I.J., van Roekel, H., Verheul, M., Baakman, C., Guryev, V., Vriend, G., Cuppen, E., 2010. Systematic generation of in vivo G protein-coupled receptor mutants in the rat. Pharmacogenomics J. doi:10.1038/tpj.2010.4.
50. van der Kraan, M., Tatro, J.B., Entwistle, M.L., Brakkee, J.H., Burbach, J.P., Adan, R.A., Gispen, W.H., 1999. Expression of melanocortin receptors and pro-opiomelanocortin in the rat spinal cord in relation to neurotrophic effects of melanocortins. Brain Res. Mol. Brain Res. 63, 276-286.
51. van der Ploeg, L.H., Martin, W.J., Howard, A.D., Nargund, R.P., Austin, C.P., Guan, X., Drisko, J., Cashen, D., Sebhat, I., Patchett, A.A., Figueroa, D.J., DiLella, A.G., Connolly, B.M., Weinberg, D.H., Tan, C.P., Palyha, O.C., Pong, S.S., Macneil, T., Rosenblum, C., Vongs, A., Tang, R., Yu, H., Sailer, A.W., Fong, T.M., Huang, C., Tota, M.R., Chang, R.S., Stearns, R., Tamvakopoulos, C., Christ, G., Drazen, D.L., Spar, B.D., Nelson, R.J., Macintyre, D.E., 2002. A role for the melanocortin 4 receptor in sexual function. Proc. Natl. Acad. Sci. U. S. A. 99, 11381-11386.
52. Voorn, P., Vanderschuren, L.J., Groenewegen, H.J., Robbins, T.W., Pennartz, C.M., 2004. Putting a spin on the dorsal-ventral divide of the striatum. Trends Neurosci. 27, 468-474. (Pubitemid 38951039)
53. Wessells, H., Gralnek, D., Dorr, R., Hruby, V.J., Hadley, M.E., Levine, N., 2000. Effect of an alpha-melanocyte stimulating hormone analog on penile erection and sexual desire in men with organic erectile dysfunction. Urology 56, 641-646.
54. Williams, D.L., Kaplan, J.M., Grill, H.J., 2000. The role of the dorsal vagal complex and the vagus nerve in feeding effects of melanocortin-3/4 receptor stimulation. Endocrinology 141, 1332-1337. (Pubitemid 32269100)