Glucocorticoid receptor and fkbp5 expression is altered following exposure to chronic stress: Modulation by antidepressant treatment

Neuropsychopharmacology

Volumn 38, Issue 4, 2013, Pages 616-627

  Guidotti, Gianluigi ^a   Calabrese, Francesca ^a   Anacker, Christoph ^b   Racagni, Giorgio ^a   Pariante, Carmine M ^b   Riva, Marco A ^a  

^a UNIVERSITY OF MILAN   (Italy)

^b Department of Psychological Medicine   (United Kingdom)

Author keywords

chronic mild stress; depression; duloxetine; HPA axis

Indexed keywords

DULOXETINE; FK 506 BINDING PROTEIN; FK 506 BINDING PROTEIN 5; GLUCOCORTICOID RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHRONIC MILD STRESS; CHRONIC STRESS; CONTROLLED STUDY; CYTOPLASM; DEPRESSION; HIPPOCAMPUS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PREFRONTAL CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT;

ANIMALS; ANTIDEPRESSIVE AGENTS; BRAIN; CHRONIC DISEASE; GENE EXPRESSION REGULATION; MALE; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GLUCOCORTICOID; STRESS, PSYCHOLOGICAL; TACROLIMUS BINDING PROTEINS; TREATMENT OUTCOME;

EID: 84873743622     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2012.225     Document Type: Article

References (48)

1. Anacker C, Zunszain PA, Cattaneo A, Carvalho LA, Garabedian MJ, Thuret S et al 2011). Antidepressants increase human hippocampal neurogenesis by activating the glucocorticoid receptor. Mol Psychiatry 16: 738-750.
2. Anisman H, Du L, Palkovits M, Faludi G, Kovacs GG, Szontagh-Kishazi P et al (2008). Serotonin receptor subtype and p11 mRNA expression in stress-relevant brain regions of suicide and control subjects. J Psychiatry Neurosci 33: 131-141.
3. Binder EB (2009). The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders. Psychoneuroendocrinology 34(Suppl 1): S186-S195.
4. Binder EB, Bradley RG, Liu W, Epstein MP, Deveau TC, KB Mercer et al (2008). Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults. JAMA 299: 1291-1305.
5. Calabrese F, Guidotti G, Molteni R, Racagni G, Mancini M, Riva MA (2012). Stress-induced changes of hippocampal NMDA receptors: modulation by duloxetine treatment. PLoS ONE 7: e37916.
6. Calabrese F, Molteni R, Cattaneo A, Macchi F, Racagni G, Gennarelli M et al (2010). Long-Term duloxetine treatment normalizes altered brain-derived neurotrophic factor expression in serotonin transporter knockout rats through the modulation of specific neurotrophin isoforms. Mol Pharmacol 77: 846-853.
7. Calabrese F, Molteni R, Maj PF, Cattaneo A, Gennarelli M, Racagni G et al (2007). Chronic duloxetine treatment induces specific changes in the expression of BDNF transcripts and in the subcellular localization of the neurotrophin protein. Neuropsychopharmacology 32: 2351-2359.
8. Calabrese F, Molteni R, Riva MA 2011). Antistress properties of antidepressant drugs and their clinical implications. Pharmacol Ther 132: 39-56.
9. Chen W, Dang T, Blind RD, Wang Z, Cavasotto CN, Hittelman AB et al (2008). Glucocorticoid receptor phosphorylation differentially affects target gene expression. Mol Endocrinol 22: 1754-1766.
10. de Kloet ER, Joels M, Holsboer F (2005). Stress and the brain: from adaptation to disease. Nat Rev Neurosci 6: 463-475.
11. Egeland M, Warner-Schmidt J, Greengard P, Svenningsson P (2010). Neurogenic effects of fluoxetine are attenuated in p11 (S100A10) knockout mice. Biol Psychiatry 67: 1048-1056.
12. Fitzsimons CP, Ahmed S, Wittevrongel CF, Schouten TG, Dijkmans TF, Scheenen WJ et al (2008). The microtubuleassociated protein doublecortin-like regulates the transport of the glucocorticoid receptor in neuronal progenitor cells. Mol Endocrinol 22: 248-262.
13. Frampton JE, Plosker GL (2007). Duloxetine: a review of its use in the treatment of major depressive disorder. CNS Drugs 21: 581-609.
14. Galliher-Beckley AJ, Williams JG, Collins JB, Cidlowski JA (2008). Glycogen synthase kinase 3beta-mediated serine phosphorylation of the human glucocorticoid receptor redirects gene expression profiles. Mol Cell Biol 28: 7309-7322.
15. Guidotti G, Calabrese F, Auletta F, Olivier J, Racagni G, Homberg J et al (2012). Developmental influence of the serotonin transporter on the expression of npas4 and GABAergic markers: modulation by antidepressant treatment. Neuropsychopharmacology 37: 746-758.
16. Hensler JG, Vogt MA, Gass P (2010). Regulation of cortical and hippocampal 5-HT(1A) receptor function by corticosterone in GR\+/-mice. Psychoneuroendocrinology 35: 469-474.
17. Holsboer F (2000). The corticosteroid receptor hypothesis of depression. Neuropsychopharmacology 23: 477-501.
18. Ising M, Depping AM, Siebertz A, Lucae S, Unschuld PG, Kloiber S et al (2008). Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls. Eur J Neurosci 28: 389-398.
19. Ismaili N, Garabedian MJ (2004). Modulation of glucocorticoid receptor function via phosphorylation. Ann NY Acad Sci 1024: 86-101.
20. Koenen KC, Saxe G, Purcell S, Smoller JW, Bartholomew D, Miller A et al (2005). Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children. Mol Psychiatry 10: 1058-1059.
21. Kronenberg G, Kirste I, Inta D, Chourbaji S, Heuser I, Endres M et al (2009). Reduced hippocampal neurogenesis in the GR(\+/-) genetic mouse model of depression. Eur Arch Psychiatry Clin Neurosci 259: 499-504.
22. Krstic MD, Rogatsky I, Yamamoto KR, Garabedian MJ (1997). Mitogen-activated and cyclin-dependent protein kinases selectively and differentially modulate transcriptional enhancement by the glucocorticoid receptor. Mol Cell Biol 17: 3947-3954.
23. Ma DK, Jang MH, Guo JU, Kitabatake Y, Chang ML, Pow-Anpongkul N et al (2009). Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis. Science 323: 1074-1077.
24. Marlatt MW, Lucassen PJ, van Praag H (2010). Comparison of neurogenic effects of fluoxetine, duloxetine and running in mice. Brain Res 1341: 93-99.
25. McEwen BS, Gould EA, Sakai RR (1992). The vulnerability of the hippocampus to protective and destructive effects of glucocorticoids in relation to stress. Br J Psychiatry Suppl 15: 18-23.
26. Molteni R, Calabrese F, Cattaneo A, Mancini M, Gennarelli M, Racagni G et al (2009). Acute stress responsiveness of the neurotrophin BDNF in the rat hippocampus is modulated by chronic treatment with the antidepressant duloxetine. Neuropsychopharmacology 34: 1523-1532.
27. Molteni R, Calabrese F, Chourbaji S, Brandwein C, Racagni G, Gass P et al (2010). Depression-prone mice with reduced glucocorticoid receptor expression display an altered stress-dependent regulation of brain-derived neurotrophic factor and activityregulated cytoskeleton-associated protein. J Psychopharmacol 24: 595-603.
28. Nemoto S, Finkel T (2002). Redox regulation of forkhead proteins through a p66shc-dependent signaling pathway. Science 295: 2450-2452.
29. Okugawa G, Omori K, Suzukawa J, Fujiseki Y, Kinoshita T, Inagaki C (1999). Long-term treatment with antidepressants increases glucocorticoid receptor binding and gene expression in cultured rat hippocampal neurones. J Neuroendocrinol 11: 887-895.
30. Pariante CM (2006). The glucocorticoid receptor: part of the solution or part of the problem? J Psychopharmacol 20: 79-84.
31. Pariante CM, Kim RB, Makoff A, Kerwin RW (2003). Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters. Br J Pharmacol 139: 1111-1118.
32. Pariante CM, Lightman SL (2008). The HPA axis in major depression: classical theories and new developments. Trends Neurosci 31: 464-468.
33. Paxinos G, Watson C (1996). The Rat Brain in Stereotaxis Coordinates. Academic Press: New York.
34. Peiffer A, Veilleux S, Barden N (1991). Antidepressant and other centrally acting drugs regulate glucocorticoid receptor messenger RNA levels in rat brain. Psychoneuroendocrinology 16: 505-515.
35. Pittenger C, Duman RS (2008). Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 33: 88-109.
36. Polter A, Yang S, Zmijewska AA, van Groen T, Paik JH, Depinho RA et al (2009). Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation. Biol Psychiatry 65: 150-159.
37. Rangarajan PN, Umesono K, Evans RM (1992). Modulation of glucocorticoid receptor function by protein kinase A. Mol Endocrinol 6: 1451-1457.
38. Ridder S, Chourbaji S, Hellweg R, Urani A, Zacher C, Schmid W et al (2005). Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J Neurosci 25: 6243-6250.
39. Rogatsky I, Waase CL, Garabedian MJ (1998). Phosphorylation and inhibition of rat glucocorticoid receptor transcriptional activation by glycogen synthase kinase-3 (GSK-3). Species-specific differences between human and rat glucocorticoid receptor signaling as revealed through GSK-3 phosphorylation. J Biol Chem 273: 14315-14321.
40. Schmidt HD, Shelton RC, Duman RS 2011). Functional biomarkers of depression: diagnosis, treatment, and pathophysiology. Neuropsychopharmacology 36: 2375-2394.
41. Shirayama Y, Chen AC, Nakagawa S, Russell DS, Duman RS (2002). Brain-derived neurotrophic factor produces antidepressant effects in behavioral models of depression. J Neurosci 22: 3251-3261.
42. Svenningsson P, Chergui K, Rachleff I, Flajolet M, Zhang X, El Yacoubi M et al (2006). Alterations in 5-HT1B receptor function by p11 in depression-like states. Science 311: 77-80.
43. Takabe S, Mochizuki K, Goda T (2008). De-phosphorylation of GR at Ser203 in nuclei associates with GR nuclear translocation and GLUT5 gene expression in Caco-2 cells. Arch Biochem Biophys 475: 1-6.
44. Tanti A, Rainer Q, Minier F, Surget A, Belzung C (2012). Differential environmental regulation of neurogenesis along the septo-temporal axis of the hippocampus. Neuropharmacology 63: 374-384.
45. Tatro ET, Everall IP, Masliah E, Hult BJ, Lucero G, Chana G et al (2009). Differential expression of immunophilins FKBP51 and FKBP52 in the frontal cortex of HIV-infected patients with major depressive disorder. J Neuroimmune Pharmacol 4: 218-226.
46. Trajkovska V, Kirkegaard L, Krey G, Marcussen AB, Thomsen MS, Chourbaji S et al (2009). Activation of glucocorticoid receptors increases 5-HT2A receptor levels. Exp Neurol 218: 83-91.
47. Wang Z, Frederick J, Garabedian MJ (2002). Deciphering the phosphorylation "code" of the glucocorticoid receptor in vivo. J Biol Chem 277: 26573-26580.
48. Warner-Schmidt JL, Flajolet M, Maller A, Chen EY, Qi H, Svenningsson P et al (2009). Role of p11 in cellular and behavioral effects of 5-HT4 receptor stimulation. J Neurosci 29: 1937-1946.