Identification of positive allosteric modulators VU0155094 (ML397) and VU0422288 (ML396) reveals new insights into the biology of metabotropic glutamate receptor 7

ACS Chemical Neuroscience

Volumn 5, Issue 12, 2014, Pages 1221-1237

  Jalan Sakrikar, Nidhi ^a   Field, Julie R ^a   Klar, Rebecca ^a   Mattmann, Margrith E ^a   Gregory, Karen J ^c   Zamorano, Rocio ^a   Engers, Darren W ^a   Bollinger, Sean R ^a   Weaver, C David ^a   Days, Emily L ^a   Lewis, L Michelle ^a   Utley, Thomas J ^a   Hurtado, Miguel ^a   Rigault, Delphine ^d   Acher, Francine ^d   Walker, Adam G ^a   Melancon, Bruce J ^a   Wood, Michael R ^a,b   Lindsley, Craig W ^a,b   Conn, P Jeffrey ^a   Xiang, Zixiu ^a   Hopkins, Corey R ^a,b   Niswender, Colleen M ^a   more..

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c MONASH UNIVERSITY   (Australia)

^d UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Allosteric modulator; Electrophysiology; Hippocampus; Metabotropic glutamate receptor

Indexed keywords

AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; METABOTROPIC RECEPTOR 7; UNCLASSIFIED DRUG; VU 0155094; VU 0422288; 2-AMINO-4-PHOSPHONO-PROPINATE; 3,4-DICARBOXYPHENYLGLYCINE; ACETANILIDE DERIVATIVE; AMINO ACID RECEPTOR AFFECTING AGENT; BENZOIC ACID DERIVATIVE; CALCIUM; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; GLUTAMIC ACID; GLYCINE; METABOTROPIC RECEPTOR; PICOLINIC ACID DERIVATIVE; PROPIONIC ACID DERIVATIVE; PYRROLE DERIVATIVE; THALLIUM; VU0155094; VU0422288;

ALLOSTERISM; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; DRUG EFFICACY; DRUG IDENTIFICATION; HIPPOCAMPUS; NEUROMODULATION; NONHUMAN; PROTEIN EXPRESSION; RAT; STRUCTURE ACTIVITY RELATION; SYNAPSE; SYNAPTIC TRANSMISSION; ANALOGS AND DERIVATIVES; ANIMAL; C57BL MOUSE; CHEMISTRY; CHO CELL LINE; CRICETULUS; DOSE RESPONSE; DRUG EFFECTS; EXCITATORY POSTSYNAPTIC POTENTIAL; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; HUMAN; IN VITRO STUDY; MALE; METABOLISM;

ACETANILIDES; ANIMALS; BENZOATES; CALCIUM; CHO CELLS; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGENTS; EXCITATORY POSTSYNAPTIC POTENTIALS; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; GLUTAMIC ACID; GLYCINE; HEK293 CELLS; HIPPOCAMPUS; HUMANS; IN VITRO TECHNIQUES; MALE; MICE, INBRED C57BL; PICOLINIC ACIDS; PROPIONATES; PYRROLES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; THALLIUM; TRANSFECTION;

EID: 84918494690     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn500153z     Document Type: Article

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