메뉴 건너뛰기




Volumn 82, Issue 3, 2012, Pages 438-447

Functional and pharmacological characteristics of metabotropic glutamate receptors 2/4 heterodimers

Author keywords

[No Author keywords available]

Indexed keywords

2 (2,3 DICARBOXYCYCLOPROPYL)GLYCINE; 2 AMINO 4 PHOSPHONOBUTYRIC ACID; HETERODIMER; METABOTROPIC RECEPTOR 2; METABOTROPIC RECEPTOR 4;

EID: 84865263040     PISSN: 0026895X     EISSN: 15210111     Source Type: Journal    
DOI: 10.1124/mol.112.078501     Document Type: Article
Times cited : (64)

References (38)
  • 1
    • 47549114034 scopus 로고    scopus 로고
    • The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino) cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors
    • Beqollari D and Kammermeier PJ (2008) The mGlu(4) receptor allosteric modulator N-phenyl-7-(hydroxyimino)cyclopropa[b]chromen-1a-carboxamide acts as a direct agonist at mGlu(6) receptors. Eur J Pharmacol 589:49-52.
    • (2008) Eur J Pharmacol , vol.589 , pp. 49-52
    • Beqollari, D.1    Kammermeier, P.J.2
  • 2
    • 77954443202 scopus 로고    scopus 로고
    • Venus fly trap domain of mGluR1 functions as a dominant negative against group I mGluR signaling
    • Beqollari D and Kammermeier PJ (2010) Venus fly trap domain of mGluR1 functions as a dominant negative against group I mGluR signaling. J Neurophysiol 104:439-448.
    • (2010) J Neurophysiol , vol.104 , pp. 439-448
    • Beqollari, D.1    Kammermeier, P.J.2
  • 3
    • 67650732945 scopus 로고    scopus 로고
    • Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs)
    • Engers DW, Niswender CM, Weaver CD, Jadhav S, Menon UN, Zamorano R, Conn PJ, Lindsley CW, and Hopkins CR (2009) Synthesis and evaluation of a series of heterobiarylamides that are centrally penetrant metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulators (PAMs).J Med Chem 52:4115-4118.
    • (2009) J Med Chem , vol.52 , pp. 4115-4118
    • Engers, D.W.1    Niswender, C.M.2    Weaver, C.D.3    Jadhav, S.4    Menon, U.N.5    Zamorano, R.6    Conn, P.J.7    Lindsley, C.W.8    Hopkins, C.R.9
  • 4
    • 79251591614 scopus 로고    scopus 로고
    • A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors
    • Doumazane E, Scholler P, Zwier JM, Eric T, Rondard P, and Pin JP (2011) A new approach to analyze cell surface protein complexes reveals specific heterodimeric metabotropic glutamate receptors.FASEB J 25:66-77.
    • (2011) FASEB J , vol.25 , pp. 66-77
    • Doumazane, E.1    Scholler, P.2    Zwier, J.M.3    Eric, T.4    Rondard, P.5    Pin, J.P.6
  • 5
    • 33745227414 scopus 로고    scopus 로고
    • Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice
    • Galici R, Jones CK, Hemstapat K, Nong Y, Echemendia NG, Williams LC, de Paulis T, and Conn PJ (2006) Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J Pharmacol Exp Ther 318:173-185.
    • (2006) J Pharmacol Exp Ther , vol.318 , pp. 173-185
    • Galici, R.1    Jones, C.K.2    Hemstapat, K.3    Nong, Y.4    Echemendia, N.G.5    Williams, L.C.6    De Paulis, T.7    Conn, P.J.8
  • 6
    • 0029908501 scopus 로고    scopus 로고
    • Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: Characterization of new antagonists
    • Gomeza J, Mary S, Brabet I, Parmentier ML, Restituito S, Bockaert J, and Pin JP (1996) Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists. Mol Pharmacol 50:923-930.
    • (1996) Mol Pharmacol , vol.50 , pp. 923-930
    • Gomeza, J.1    Mary, S.2    Brabet, I.3    Parmentier, M.L.4    Restituito, S.5    Bockaert, J.6    Pin, J.P.7
  • 8
    • 38449091312 scopus 로고    scopus 로고
    • Group I mGluRs and long-term depression: Potential roles in addiction?
    • Grueter BA, McElligott ZA, and Winder DG (2007) Group I mGluRs and long-term depression: potential roles in addiction? Mol Neurobiol 36:232-244.
    • (2007) Mol Neurobiol , vol.36 , pp. 232-244
    • Grueter, B.A.1    McElligott, Z.A.2    Winder, D.G.3
  • 12
    • 0030629369 scopus 로고    scopus 로고
    • Heterologous expression of receptors and signaling proteins in adult mammalian sympathetic neurons by microinjection
    • Ikeda SR (1997) Heterologous expression of receptors and signaling proteins in adult mammalian sympathetic neurons by microinjection. Methods Mol Biol 83:191-202.
    • (1997) Methods Mol Biol , vol.83 , pp. 191-202
    • Ikeda, S.R.1
  • 13
    • 0029921401 scopus 로고    scopus 로고
    • Voltage-dependent modulation of N-type calcium channels by G-protein beta gamma subunits
    • Ikeda SR (1996) Voltage-dependent modulation of N-type calcium channels by G-protein beta gamma subunits. Nature 380:255-258.
    • (1996) Nature , vol.380 , pp. 255-258
    • Ikeda, S.R.1
  • 14
    • 0033609661 scopus 로고    scopus 로고
    • Heterologous expression of a green fluorescent protein-pertussis toxin S1 subunit fusion construct disrupts calcium channel modulation in rat superior cervical ganglion neurons
    • Ikeda SR, Jeong SW, Kammermeier PJ, Ruiz-Velasco V, and King MM (1999) Heterologous expression of a green fluorescent protein-pertussis toxin S1 subunit fusion construct disrupts calcium channel modulation in rat superior cervical ganglion neurons. Neurosci Lett 271:163-166.
    • (1999) Neurosci Lett , vol.271 , pp. 163-166
    • Ikeda, S.R.1    Jeong, S.W.2    Kammermeier, P.J.3    Ruiz-Velasco, V.4    King, M.M.5
  • 15
    • 0027209890 scopus 로고
    • A novel metabotropic glutamate receptor agonist: Marked depression of monosynaptic excitation in the newborn rat isolated spinal cord
    • Ishida M, Saitoh T, Shimamoto K, Ohfune Y, and Shinozaki H (1993) A novel metabotropic glutamate receptor agonist: marked depression of monosynaptic excitation in the newborn rat isolated spinal cord. Br J Pharmacol 109:1169-1177.
    • (1993) Br J Pharmacol , vol.109 , pp. 1169-1177
    • Ishida, M.1    Saitoh, T.2    Shimamoto, K.3    Ohfune, Y.4    Shinozaki, H.5
  • 16
  • 17
    • 0033119326 scopus 로고    scopus 로고
    • Expression of RGS2 alters the coupling of metabotropic glutamate receptor 1a to M-type K+ and N-type Ca2+ channels
    • Kammermeier PJ and Ikeda SR (1999) Expression of RGS2 alters the coupling of metabotropic glutamate receptor 1a to M-type K+ and N-type Ca2+ channels. Neuron 22:819-829.
    • (1999) Neuron , vol.22 , pp. 819-829
    • Kammermeier, P.J.1    Ikeda, S.R.2
  • 18
    • 13244289922 scopus 로고    scopus 로고
    • Activation of metabotropic glutamate receptor 1 dimers requires glutamate binding in both subunits
    • Kammermeier PJ and Yun J (2005) Activation of metabotropic glutamate receptor 1 dimers requires glutamate binding in both subunits. J Pharmacol Exp Ther 312:502-508.
    • (2005) J Pharmacol Exp Ther , vol.312 , pp. 502-508
    • Kammermeier, P.J.1    Yun, J.2
  • 19
    • 3543036363 scopus 로고    scopus 로고
    • Closed state of both binding domains of homodimeric mGlu receptors is required for full activity
    • Kniazeff J, Bessis AS, Maurel D, Ansanay H, Prézeau L, and Pin JP (2004) Closed state of both binding domains of homodimeric mGlu receptors is required for full activity. Nat Struct Mol Biol 11:706-713.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 706-713
    • Kniazeff, J.1    Bessis, A.S.2    Maurel, D.3    Ansanay, H.4    Prézeau, L.5    Pin, J.P.6
  • 20
    • 0033517048 scopus 로고    scopus 로고
    • Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists
    • Kolczewski S, Adam G, Stadler H, Mutel V, Wichmann J, and Woltering T (1999) Synthesis of heterocyclic enol ethers and their use as group 2 metabotropic glutamate receptor antagonists. Bioorg Med Chem Lett 9:2173-2176.
    • (1999) Bioorg Med Chem Lett , vol.9 , pp. 2173-2176
    • Kolczewski, S.1    Adam, G.2    Stadler, H.3    Mutel, V.4    Wichmann, J.5    Woltering, T.6
  • 22
    • 79960604663 scopus 로고    scopus 로고
    • Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: Mechanistic studies with new potent negative allosteric modulators
    • Lundström L, Bissantz C, Beck J, Wettstein JG, Woltering TJ, Wichmann J, and Gatti S (2011) Structural determinants of allosteric antagonism at metabotropic glutamate receptor 2: mechanistic studies with new potent negative allosteric modulators. Br J Pharmacol 164:521-537.
    • (2011) Br J Pharmacol , vol.164 , pp. 521-537
    • Lundström, L.1    Bissantz, C.2    Beck, J.3    Wettstein, J.G.4    Woltering, T.J.5    Wichmann, J.6    Gatti, S.7
  • 24
    • 77953611540 scopus 로고    scopus 로고
    • Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction
    • Moussawi K and Kalivas PW (2010) Group II metabotropic glutamate receptors (mGlu2/3) in drug addiction. Eur J Pharmacol 639:115-122.
    • (2010) Eur J Pharmacol , vol.639 , pp. 115-122
    • Moussawi, K.1    Kalivas, P.W.2
  • 25
    • 0036895272 scopus 로고    scopus 로고
    • Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment
    • Picconi B, Pisani A, Centonze D, Battaglia G, Storto M, Nicoletti F, Bernardi G, and Calabresi P (2002) Striatal metabotropic glutamate receptor function following experimental parkinsonism and chronic levodopa treatment. Brain 125:2635-2645.
    • (2002) Brain , vol.125 , pp. 2635-2645
    • Picconi, B.1    Pisani, A.2    Centonze, D.3    Battaglia, G.4    Storto, M.5    Nicoletti, F.6    Bernardi, G.7    Calabresi, P.8
  • 26
    • 0028331717 scopus 로고
    • Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures
    • Prézeau L, Carrette J, Helpap B, Curry K, Pin JP, and Bockaert J (1994) Pharmacological characterization of metabotropic glutamate receptors in several types of brain cells in primary cultures. Mol Pharmacol 45:570-577.
    • (1994) Mol Pharmacol , vol.45 , pp. 570-577
    • Prézeau, L.1    Carrette, J.2    Helpap, B.3    Curry, K.4    Pin, J.P.5    Bockaert, J.6
  • 27
    • 0032973978 scopus 로고    scopus 로고
    • Characterization of the dimerization of metabotropic glutamate receptors using an N-terminal truncation of mGluR1alpha
    • Robbins MJ, Ciruela F, Rhodes A, and McIlhinney RA (1999) Characterization of the dimerization of metabotropic glutamate receptors using an N-terminal truncation of mGluR1alpha. J Neurochem 72:2539-2547.
    • (1999) J Neurochem , vol.72 , pp. 2539-2547
    • Robbins, M.J.1    Ciruela, F.2    Rhodes, A.3    McIlhinney, R.A.4
  • 28
    • 0029903640 scopus 로고    scopus 로고
    • Metabotropic glutamate receptor 5 is a disulfide-linked dimer
    • Romano C, Yang WL, and O'Malley KL (1996) Metabotropic glutamate receptor 5 is a disulfide-linked dimer. J Biol Chem 271:28612-28616.
    • (1996) J Biol Chem , vol.271 , pp. 28612-28616
    • Romano, C.1    Yang, W.L.2    O'Malley, K.L.3
  • 29
    • 0037423395 scopus 로고    scopus 로고
    • Amino acid mutagenesis of the ligand binding site and the dimer interface of the metabotropic glutamate receptor 1. Identification of crucial residues for setting the activated state
    • Sato T, Shimada Y, Nagasawa N, Nakanishi S, and Jingami H (2003) Amino acid mutagenesis of the ligand binding site and the dimer interface of the metabotropic glutamate receptor 1. Identification of crucial residues for setting the activated state. J Biol Chem 278:4314-4321.
    • (2003) J Biol Chem , vol.278 , pp. 4314-4321
    • Sato, T.1    Shimada, Y.2    Nagasawa, N.3    Nakanishi, S.4    Jingami, H.5
  • 30
    • 0034811597 scopus 로고    scopus 로고
    • Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system
    • Schoepp DD (2001) Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther 299:12-20.
    • (2001) J Pharmacol Exp Ther , vol.299 , pp. 12-20
    • Schoepp, D.D.1
  • 31
    • 0036328482 scopus 로고    scopus 로고
    • Characterization of an N-terminal secreted domain of the type-1 human metabotropic glutamate receptor produced by a mammalian cell line
    • Selkirk JV, Challiss RA, Rhodes A, and McIlhinney RA (2002) Characterization of an N-terminal secreted domain of the type-1 human metabotropic glutamate receptor produced by a mammalian cell line. J Neurochem 80:346-353.
    • (2002) J Neurochem , vol.80 , pp. 346-353
    • Selkirk, J.V.1    Challiss, R.A.2    Rhodes, A.3    McIlhinney, R.A.4
  • 32
    • 0031063994 scopus 로고    scopus 로고
    • A modification of receptor theory. 1956
    • Stephenson RP (1997) A modification of receptor theory. 1956. Br J Pharmacol 120 (Suppl 1):106-120.
    • (1997) Br J Pharmacol , vol.120 , Issue.SUPPL. 1 , pp. 106-120
    • Stephenson, R.P.1
  • 33
    • 3042551375 scopus 로고    scopus 로고
    • Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1alpha
    • Tateyama M, Abe H, Nakata H, Saito O, and Kubo Y (2004) Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1alpha. Nat Struct Mol Biol 11:637-642.
    • (2004) Nat Struct Mol Biol , vol.11 , pp. 637-642
    • Tateyama, M.1    Abe, H.2    Nakata, H.3    Saito, O.4    Kubo, Y.5
  • 34
    • 79959934459 scopus 로고    scopus 로고
    • The intra-molecular activation mechanisms of the dimeric metabotropic glutamate receptor 1 differ depending on the type of G proteins
    • Tateyama M and Kubo Y (2011) The intra-molecular activation mechanisms of the dimeric metabotropic glutamate receptor 1 differ depending on the type of G proteins. Neuropharmacology 61:832-841.
    • (2011) Neuropharmacology , vol.61 , pp. 832-841
    • Tateyama, M.1    Kubo, Y.2
  • 35
    • 0037022586 scopus 로고    scopus 로고
    • Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+
    • Tsuchiya D, Kunishima N, Kamiya N, Jingami H, and Morikawa K (2002) Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+. Proc Natl Acad Sci USA 99:2660-2665.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 2660-2665
    • Tsuchiya, D.1    Kunishima, N.2    Kamiya, N.3    Jingami, H.4    Morikawa, K.5
  • 36
    • 84856072333 scopus 로고    scopus 로고
    • Metabotropic glutamate receptors as therapeutic targets for schizophrenia
    • Vinson PN and Conn PJ (2012) Metabotropic glutamate receptors as therapeutic targets for schizophrenia. Neuropharmacology 62:1461-1472.
    • (2012) Neuropharmacology , vol.62 , pp. 1461-1472
    • Vinson, P.N.1    Conn, P.J.2
  • 37
    • 79959553823 scopus 로고    scopus 로고
    • Comparative fluorescence resonance energy transfer analysis of metabotropic glutamate receptors: Implications about the dimeric arrangement and rearrangement upon ligand bindings
    • Yanagawa M, Yamashita T, and Shichida Y (2011) Comparative fluorescence resonance energy transfer analysis of metabotropic glutamate receptors: implications about the dimeric arrangement and rearrangement upon ligand bindings. J Biol Chem 286:22971-22981.
    • (2011) J Biol Chem , vol.286 , pp. 22971-22981
    • Yanagawa, M.1    Yamashita, T.2    Shichida, Y.3
  • 38
    • 0027305477 scopus 로고
    • Adenosine modulates voltage-gated Ca2+ channels in adult rat sympathetic neurons
    • Zhu Y and Ikeda SR (1993) Adenosine modulates voltage-gated Ca2+ channels in adult rat sympathetic neurons. J Neurophysiol 70:610-620.
    • (1993) J Neurophysiol , vol.70 , pp. 610-620
    • Zhu, Y.1    Ikeda, S.R.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.