The mGluR7 allosteric agonist AMN082 produces antidepressant-like effects by modulating glutamatergic signaling

Pharmacology Biochemistry and Behavior

Volumn 101, Issue 1, 2012, Pages 35-40

  Bradley, Stefania Risso ^a   Uslaner, Jason M ^a   Flick, Rose B ^a   Lee, Ariel ^a   Groover, Kristina M ^a   Hutson, Peter H ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

AMPA receptors; Antidepressants; Metabotropic glutamate receptor 7; NR1; NR2b subunits; Phosphorylation of GluR1

Indexed keywords

6 NITRO 7 SULFAMOYLBENZO[F]QUINOXALINE 2,3 DIONE; ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; AMN 082; ANTIDEPRESSANT AGENT; DESIPRAMINE; GLUTAMATE RECEPTOR 1; IMIPRAMINE; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR AGONIST; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 2B; N,N' DIBENZYHYDRYL ETHANE 1,2 DIAMINE DIHYDROCHLORIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDEPRESSANT ACTIVITY; ANTIDEPRESSANT LIKE EFFECT; ARTICLE; ASSAY; CONTROLLED STUDY; DEPRESSION; DIFFERENTIAL REINFORCEMENT OF LOW RATE OF RESPONDING ASSAY; DRUG ANALYSIS; DRUG MECHANISM; EXPERIMENTAL TEST; FORCED SWIMMING TEST; HIPPOCAMPUS; MALE; MOUSE; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION; TAIL SUSPENSION TEST;

ANIMALS; ANTIDEPRESSIVE AGENTS; BENZHYDRYL COMPOUNDS; CHO CELLS; CONDITIONING, OPERANT; CRICETINAE; CRICETULUS; CYCLIC AMP; GLUTAMIC ACID; HINDLIMB SUSPENSION; HIPPOCAMPUS; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; QUINOXALINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, AMPA; RECEPTORS, METABOTROPIC GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; REINFORCEMENT SCHEDULE; SIGNAL TRANSDUCTION;

EID: 83455229501     PISSN: 00913057     EISSN: 18735177     Source Type: Journal    
DOI: 10.1016/j.pbb.2011.11.006     Document Type: Article

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