Lu AF21934, a positive allosteric modulator of mGlu4 receptors, reduces the harmaline-induced hyperactivity but not tremor in rats

Neuropharmacology

Volumn 83, Issue , 2014, Pages 28-35

  Ossowska, Krystyna ^a   Wardas, Jadwiga ^a   Berghauzen Maciejewska, Klemencja ^a   Głowacka, Urszula ^a   Kuter, Katarzyna ^a   Pilc, Andrzej ^a   Zorn, Stevin H ^b   Doller, Dario ^b  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b LUNDBECK RESEARCH USA   (United States)

Author keywords

Cerebellum; Harmaline; Hyperactivation; Inferior olive; Metabotropic glutamate receptor 4; Tremor

Indexed keywords

GLUTAMATE RECEPTOR AGONIST; LU AF 21934; MESSENGER RNA; METABOTROPIC RECEPTOR 4; UNCLASSIFIED DRUG; ANILIDE; CENTRAL STIMULANT AGENT; CYCLOHEXANECARBOXYLIC ACID DERIVATIVE; HARMALINE; METABOTROPIC RECEPTOR; N1-(3,4-DICHLOROPHENYL)-CYCLOHEXANE-1,2-DICARBOXAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CEREBELLUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; EXPLORATORY BEHAVIOR; GENE EXPRESSION; HYPERACTIVITY; IN SITU HYBRIDIZATION; INFERIOR OLIVE; MALE; MOTOR ACTIVITY; NONHUMAN; PRIORITY JOURNAL; RAT; TREMOR; AGONISTS; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; HYPERKINESIA; METABOLISM; WISTAR RAT;

ANILIDES; ANIMALS; CENTRAL NERVOUS SYSTEM STIMULANTS; CEREBELLUM; CYCLOHEXANECARBOXYLIC ACIDS; HARMALINE; HYPERKINESIS; MALE; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; TREMOR;

EID: 84898820254     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2014.03.018     Document Type: Article

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