Contribution of the mGluR7 receptor to antiparkinsonian-like effects in rats: A behavioral study with the selective agonist AMN082

Pharmacological Reports

Volumn 65, Issue 5, 2013, Pages 1194-1203

  Konieczny, Jolanta ^a   Lenda, Tomasz ^a  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

Author keywords

Akinesia; AMN082; Basal ganglia; Catalepsy; Metabotropic glutamate receptor; Parkinson's disease

Indexed keywords

AMN 082; HALOPERIDOL; METABOTROPIC RECEPTOR 7; METABOTROPIC RECEPTOR AGONIST; N,N' DIBENZHYDRYLETHANE 1,2 DIAMINE; RESERPINE; UNCLASSIFIED DRUG;

AKATHISIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATALEPSY; CONTROLLED STUDY; CORPUS STRIATUM; DRUG DOSE COMPARISON; MALE; NONHUMAN; PARKINSONISM; RAT; SUBSTANTIA NIGRA;

ANIMALS; ANTIPARKINSON AGENTS; BEHAVIOR, ANIMAL; BENZHYDRYL COMPOUNDS; BRAIN; CATALEPSY; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DYSKINESIA, DRUG-INDUCED; EXCITATORY AMINO ACID AGONISTS; HALOPERIDOL; MALE; MOTOR ACTIVITY; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; RESERPINE; TIME FACTORS;

EID: 84894135559     PISSN: 22995684     EISSN: 22995684     Source Type: Journal    
DOI: 10.1016/S1734-1140(13)71477-4     Document Type: Article

References (45)

1. Amalric M, Moukhles H, Nieoullon A, Daszuta A: Complex deficits on reaction time performance following bilateral intrastriatal 6-OHDA infusion in the rat. Eur J Neurosci, 1995, 7, 972-980.
2. Austin PJ, Betts MJ, Broadstock M, O'Neill MJ, Mitchell SN, Duty S: Symptomatic and neuroprotective effects following activation of nigral group III metabotropic glutamate receptors in rodent models of Parkinson's disease. Br J Pharmacol, 2010, 160, 1741-1753.
3. Beurrier C, Lopez S, Révy D, Selvam C, Goudet C, Lhérondel M, Gubellini P et al.: Electrophysiological and behavioral evidence that modulation of metabotropic glutamate receptor 4 with a new agonist reverses experimental parkinsonism. FASEB J, 2009, 23, 3619-3628.
4. Bradley SR, Levey AI, Hersch SM, Conn PJ: Immunocytochemical localization of group III metabotropic glutamate receptors in the hippocampus with subtypespecific antibodies. J Neurosci, 1996, 16, 2044-2056. (Pubitemid 26144017)
5. Bradley SR, Marino MJ, Whittmann M, Rouse ST, Levey AI, Conn PJ: Physiological roles of presynaptically localized type 2, 3 and 7 metabotropic glutamate receptors in the basal ganglia. Soc Neurosci Abstr, 1999, 25, 176.16.
6. Bradley SR, Standaert DG, Rhodes KJ, Rees HD, Testa CM, Levey AI, Conn PJ: Immunohistochemical localization of subtype 4a metabotropic glutamate receptors in the rat and mouse basal ganglia. J Comp Neurol, 1999, 407, 33-46. (Pubitemid 29161991)
7. Broadstock M, Austin P, Betts M, Duty S: Antiparkinsonian potential of targeting group III metabotropic glutamate receptor subtypes in the rodent substantia nigra pars reticulata. Br J Pharmacol, 2012, 165, 1034-1045.
8. Costall B, Naylor RJ, Olley JE: Stereotypic and anticataleptic activities of amphetamine after intracerebral injections. Eur J Pharmacol, 1972, 18, 83-94.
9. Cousins MS, Salamone JD: Involvement of ventrolateral striatal dopamine in movement initiation and execution: a microdialysis and behavioral investigation. Neuroscience, 1996, 70, 849-859. (Pubitemid 26013291)
10. Greco B, Lopez S, van der Putten H, Flor PJ, Amalric M: Metabotropic glutamate 7 receptor subtype modulates motor symptoms in rodent models of Parkinson's disease. J Pharmacol Exp Ther, 2010, 332, 1064-1071.
11. Hansard MJ, Smith LA, Jackson MJ, Cheetham SC, Jenner P: Dopamine, but not norepinephrine or serotonin, reuptake inhibition reverses motor deficits in 1-methyl- 4-phenyl-1,2,3,6-tetrahydropyridine-treated primates. J Pharmacol Exp Ther, 2002, 303, 952-958. (Pubitemid 35424376)
12. Hauber W, Schmidt WJ: The NMDA antagonist dizocilpine (MK-801) reverses haloperidol-induced movement initiation deficits. Behav Brain Res, 1990, 41, 161-166.
13. Kelley AE, Lang CG: Effects of GBR 12909, a selective dopamine uptake inhibitor, on motor activity and operant behavior in the rat. Eur J Pharmacol, 1989, 167, 385-395. (Pubitemid 19216543)
14. Kinoshita A, Shigemoto R, Ohishi H, van der Putten H, Mizuno N: Immunohistochemical localization of metabotropic glutamate receptors, mGluR7a and mGluR7b, in the central nervous system of the adult rat and mouse: a light and electron microscopic study. J Comp Neurol, 1998, 393, 332-352. (Pubitemid 28164590)
15. Konieczny J, Lenda T: Contribution of the mGluR7 receptor to antiparkinsonian-like effects in rats: a behavioral study with the new selective agonist AMN082. Pharmacol Rep, 2007, 59, 807. (Pubitemid 351586577)
16. Konieczny J, Przegalinski E, Pokorski M: N-oleoyldopamine decreases muscle rigidity induced by reserpine in rats. Int J Immunopathol Pharmacol, 2009, 22, 21-28.
17. Konieczny J, Wardas J, Kuter K, Pilc A, Ossowska K: The influence of group III metabotropic glutamate receptor stimulation by (1S,3R,4S)-1- aminocyclo-pentane- -1,3,4-tricarboxylic acid on the parkinsonian-like akinesia and striatal proenkephalin and prodynorphin mRNA expression in rats. Neuroscience, 2007, 145, 611-620. (Pubitemid 46341652)
18. Kosinski CM, Risso Bradley S, Conn PJ, Levey AI, Landwehrmeyer GB, Penney JB Jr., Young AB, Standaert DG: Localization of metabotropic glutamate receptor 7 mRNA and mGluR7a protein in the rat basal ganglia. J Comp Neurol, 1999, 415, 266-284. (Pubitemid 29519881)
19. Li X, Gardner EL, Xi ZX: The metabotropic glutamate receptor 7 (mGluR7) allosteric agonist AMN082 modulates nucleus accumbens GABAand glutamate, but not dopamine, in rats. Neuropharmacology, 2008, 54, 542-551.
20. Li X, Li J, Gardner EL, Xi ZX: Activation of mGluR7s inhibits cocaine-induced reinstatement of drug-seeking behavior by a nucleus accumbens glutamate-mGluR2/3 mechanism in rats. J Neurochem, 2010, 114, 1368-1380.
21. Lopez S, Turle-Lorenzo N, Acher F, De Leonibus E, Mele A, Amalric M: Targeting group III metabotropic glutamate receptors produces complex behavioral effects in rodent models of Parkinson's disease. J Neurosci, 2007, 27, 6701-6711. (Pubitemid 46983444)
22. MacInnes N, Messenger MJ, Duty S: Activation of group III metabotropic glutamate receptors in selected regions of the basal ganglia alleviates akinesia in the reserpine-treated rat. Br J Pharmacol, 2004, 141, 15-22. (Pubitemid 38241159)
23. Marino MJ, Williams DL Jr., O'Brien JA, Valenti O, McDonald TP, Clements MK, Wang R et al.: Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc Natl Acad Sci USA, 2003, 100, 13668-13673. (Pubitemid 37444797)
24. Messenger MJ, Dawson LG, Duty S: Changes in metabotropic glutamate receptor 1-8 gene expression in the rodent basal ganglia motor loop following lesion of the nigrostriatal tract. Neuropharmacology, 2002, 43, 261-271. (Pubitemid 35247614)
25. Mitsukawa K, Yamamoto R, Ofner S, Nozulak J, Pescott O, Lukic S, Stoehr N et al.: A selective metabotropic glutamate receptor 7 agonist: activation of receptor signaling via an allosteric site modulates stress parameters in vivo. Proc Natl Acad Sci USA, 2005, 102, 18712-18717. (Pubitemid 43011291)
26. Nakachi N, Kiuchi Y, Inagaki M, Inazu M, Yamazaki Y, Oguchi K: Effects of various dopamine uptake inhibitors on striatal extracellular dopamine levels and behaviours in rats. Eur J Pharmacol, 1995, 281, 195-203.
27. Niswender CM, Johnson KA, Weaver CD, Jones CK, Xiang Z, Luo Q, Rodriguez AL et al.: Discovery, characterization, and antiparkinsonian effect of novel positive allosteric modulators of metabotropic glutamate receptor 4. Mol Pharmacol, 2008, 74, 1345-1358.
28. Ohishi H, Nomura S, Ding YQ, Shigemoto R, Wada E, Kinoshita A, Li JL et al.: Presynaptic localization of a metabotropic glutamate receptor, mGluR7, in the primary afferent neurons: an immunohistochemical study in the rat. Neurosci Lett, 1995, 202, 85-88. (Pubitemid 26011563)
29. Ossowska K, Konieczny J, Wolfarth S, Pilc A: MTEP, a new selective antagonist of the metabotropic glutamate receptor subtype 5 (mGluR5), produces antiparkinsonian- like effects in rats. Neuropharmacology, 2005, 49, 447-455. (Pubitemid 41169969)
30. Paucha A, Klak K, Branski P, van der Putten H, Flor PJ, Pilc A: Activation of the mGlu7 receptor elicits antidepressant-like effects in mice. Psychopharmacology (Berl), 2007, 194, 555-562. (Pubitemid 47492987)
31. Paucha-Poniewiera A, Brañski P, Lenda T, Pilc A: The antidepressant-like action of metabotropic glutamate 7 receptor agonist N,N'-bis(diphenylmethyl)-1,2- ethanediamine (AMN082) is serotonin-dependent. J Pharmacol Exp Ther, 2010, 334, 1066-1074.
32. Paxinos G, Watson C: The rat brain in stereotactic coordinates. Academic Press, San Diego,1986.
33. Pearce RK, Smith LA, Jackson MJ, Banerji T, Scheel- Krüger J, Jenner P: The monoamine reuptake blocker brasofensine reverses akinesia without dyskinesia in MPTP-treated and levodopa-primed common marmosets. Mov Disord, 2002, 17, 877-886. (Pubitemid 36040992)
34. Pelkey KA, Yuan X, Lavezzari G, Roche KW, McBain CJ: mGluR7 undergoes rapid internalization in response to activation by the allosteric agonist AMN082. Neuropharmacology, 2007, 52, 108-117. (Pubitemid 46026829)
35. Pisani A, Calabresi P, Centonze D, Bernardi G: Activation of group III metabotropic glutamate receptors depresses glutamatergic transmission at corticostriatal synapse. Neuropharmacology, 1997, 36, 845-851. (Pubitemid 27286738)
36. Sarre S, Yuan H, Jonkers N, Van Hemelrijck A, Ebinger G, Michotte Y: In vivo characterization of somatodendritic dopamine release in the substantia nigra of 6-hydroxydopamine-lesioned rats. J Neurochem, 2004, 90, 29-39. (Pubitemid 38879159)
37. Schoepp DD: Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system. J Pharmacol Exp Ther, 2001, 299, 12-20. (Pubitemid 32905113)
38. Shigemoto R, Kinoshita A,Wada E, Nomura S, Ohishi H, Takada M, Flor PJ et al.: Differential presynaptic localization of metabotropic glutamate receptor subtypes in the rat hippocampus. J Neurosci, 1997, 17, 7503-7522. (Pubitemid 27413281)
39. Sukoff Rizzo SJ, Leonard SK, Gilbert A, Dollings P, Smith DL, Zhang MY, Di L et al.: The metabotropic glutamate receptor 7 allosteric modulator AMN082: a monoaminergic agent in disguise? J Pharmacol Exp Ther, 2011, 338, 345-352.
40. Valenti O, Marino MJ, Wittmann M, Lis E, DiLella AG, Kinney GG, Conn PJ: Group III metabotropic glutamate receptor-mediated modulation of the striatopallidal synapse. J Neurosci, 2003, 23, 7218-7226. (Pubitemid 36975886)
41. Vernon AC, Zbarsky V, Datla KP, Dexter DT, Croucher MJ: Selective activation of group III metabotropic glutamate receptors by L-(+)-2-amino-4- phosphonobutryic acid protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo. J Pharmacol Exp Ther, 2007, 320, 397-409. (Pubitemid 46025754)
42. Wardas J, Konieczny J, Lorenc-Koci E: SCH 58261, an A2A adenosine receptor antagonist, counteracts parkinsonian- like muscle rigidity in rats. Synapse, 2001, 41, 160-171.
43. Wittmann M, Marino MJ, Bradley SR, Conn PJ: Activation of group III mGluRs inhibits GABAergic and glutamatergic transmission in the substantia nigra pars reticulata. J Neurophysiol, 2001, 85, 1960-1968. (Pubitemid 32440675)
44. Wittmann M, Marino MJ, Conn PJ: Dopamine modulates the function of group II and group III metabotropic glutamate receptors in the substantia nigra pars reticulata. J Pharmacol Exp Ther, 2002, 302, 433-441. (Pubitemid 34787205)
45. Yuan J, Callahan BT, McCann UD, Ricaurte GA: Evidence against an essential role of endogenous brain dopamine in methamphetamine-induced dopaminergic neurotoxicity. J Neurochem, 2001, 77, 1338-1347. (Pubitemid 32523687)