Anxiolytic- but not antidepressant-like activity of Lu AF21934, a novel, selective positive allosteric modulator of the mGlu4 receptor

Neuropharmacology

Volumn 66, Issue , 2013, Pages 225-235

  Sławińska, Anna ^a   Wierońska, Joanna M ^a   Stachowicz, Katarzyna ^a   Pałucha Poniewiera, Agnieszka ^a   Uberti, Michelle A ^b   Bacolod, Maria A ^b   Doller, Dario ^b   Pilc, Andrzej ^a,c  

^a INSTITUTE OF PHARMACOLOGY   (Poland)

^b LUNDBECK RESEARCH USA   (United States)

^c JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Anxiety; Four plate test; GABA; Glutamate; Lu AF21934; Marble burying test; mGlu4 receptor; Positive allosteric modulator; Serotonin; stress induced hyperthermia

Indexed keywords

ANXIOLYTIC AGENT; DIAZEPAM; LU AF 21934; LU AF 21935; SEROTONIN 1A RECEPTOR; TRANQUILIZER; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG RESPONSE; DRUG STRUCTURE; GABAERGIC SYSTEM; HOT PLATE TEST; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BLOCKING; TRANQUILIZING ACTIVITY;

ALLOSTERIC REGULATION; ANILIDES; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; BRAIN; CYCLOHEXANECARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUMAZENIL; GABA-A RECEPTOR ANTAGONISTS; MALE; MICE; MICE, INBRED C57BL; MOTOR ACTIVITY; PIPERAZINES; PYRIDINES; RATS; RATS, WISTAR; RECEPTORS, METABOTROPIC GLUTAMATE; RITANSERIN; SEROTONIN; SEROTONIN ANTAGONISTS;

EID: 84872152569     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2012.05.001     Document Type: Article

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