ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice

ACS Chemical Neuroscience

Volumn 4, Issue 9, 2013, Pages 1278-1286

  Kaufmann, Kristian ^a   Romaine, Ian ^a,b   Days, Emily ^a   Pascual, Conrado ^c   Malik, Adam ^c   Yang, Liya ^c   Zou, Bende ^c   Du, Yu ^a   Sliwoski, Greg ^a   Morrison, Ryan D ^a,b   Denton, Jerod ^a,b   Niswender, Colleen M ^a   Daniels, J Scott ^a,b   Sulikowski, Gary A ^a,b   Xie, Xinmin ^c   Lindsley, Craig W ^a,b   Weaver, C David ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b VANDERBILT UNIVERSITY   (United States)

^c AfaSci Research Laboratory   (United States)

Author keywords

activator; epilepsy; G protein; GIRK; inward rectifier; potassium channel

Indexed keywords

1 (3,4 DIFLUOROPHENYL) 3 (3 METHYL 1 PHENYL 1H PYRAZOL YL)UREA; ANTICONVULSIVE AGENT; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; ML 297; UNCLASSIFIED DRUG; VALPROIC ACID; VU 0456810;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT THERAPY; ARTICLE; BRAIN; CELL STRAIN HEK293; CONTROLLED STUDY; CONVULSION; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG EFFICACY; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; HUMAN; HUMAN CELL; IN VIVO STUDY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REWARD;

ANIMALS; ANTICONVULSANTS; CALCIUM SIGNALING; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; ELECTROSHOCK; G PROTEIN-COUPLED INWARDLY-RECTIFYING POTASSIUM CHANNELS; HEK293 CELLS; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; INJECTIONS, INTRAPERITONEAL; MICE; MICROSOMES, LIVER; MOLECULAR STRUCTURE; PATCH-CLAMP TECHNIQUES; PENTYLENETETRAZOLE; PHENYLUREA COMPOUNDS; PYRAZOLES; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; RECOMBINANT PROTEINS; SEIZURES; VALPROIC ACID;

EID: 84884362547     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn400062a     Document Type: Article

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