메뉴 건너뛰기




Volumn 136, Issue , 2014, Pages 15-21

From fat fruit fly to human obesity

Author keywords

Drosophila melanogaster; Fat deposition; Feeding behavior; Genetic tools; Metabolic homeostasis; Obesity

Indexed keywords

GLYCOGEN; TRIACYLGLYCEROL; FAT;

EID: 84917734608     PISSN: 00319384     EISSN: 1873507X     Source Type: Journal    
DOI: 10.1016/j.physbeh.2014.01.017     Document Type: Review
Times cited : (31)

References (61)
  • 1
    • 60449083172 scopus 로고    scopus 로고
    • The epicurean fly: using Drosophila melanogaster to study metabolism
    • Bharucha K.N. The epicurean fly: using Drosophila melanogaster to study metabolism. Pediatr Res 2009, 65(2):132-137.
    • (2009) Pediatr Res , vol.65 , Issue.2 , pp. 132-137
    • Bharucha, K.N.1
  • 2
    • 59149105634 scopus 로고    scopus 로고
    • A supersized list of obesity genes
    • Hofker M., Wijmenga C. A supersized list of obesity genes. Nat Genet 2009, 41(2):139-140.
    • (2009) Nat Genet , vol.41 , Issue.2 , pp. 139-140
    • Hofker, M.1    Wijmenga, C.2
  • 3
    • 76749087130 scopus 로고    scopus 로고
    • Further understanding of fat biology: lessons from a fat fly
    • Hong J.W., Park K.W. Further understanding of fat biology: lessons from a fat fly. Exp Mol Med 2010, 42(1):12-20.
    • (2010) Exp Mol Med , vol.42 , Issue.1 , pp. 12-20
    • Hong, J.W.1    Park, K.W.2
  • 4
    • 84871821124 scopus 로고    scopus 로고
    • Lipid metabolism in Drosophila: development and disease
    • Liu Z., Huang X. Lipid metabolism in Drosophila: development and disease. Acta Biochim Biophys Sin (Shanghai) 2013, 45(1):44-50.
    • (2013) Acta Biochim Biophys Sin (Shanghai) , vol.45 , Issue.1 , pp. 44-50
    • Liu, Z.1    Huang, X.2
  • 5
    • 84867867191 scopus 로고    scopus 로고
    • What model organisms and interactomics can reveal about the genetics of human obesity
    • Williams M.J., Almen M.S., Fredriksson R., Schioth H.B. What model organisms and interactomics can reveal about the genetics of human obesity. Cell Mol Life Sci 2012, 69(22):3819-3834.
    • (2012) Cell Mol Life Sci , vol.69 , Issue.22 , pp. 3819-3834
    • Williams, M.J.1    Almen, M.S.2    Fredriksson, R.3    Schioth, H.B.4
  • 6
    • 84860260269 scopus 로고    scopus 로고
    • Drosophila: a model for understanding obesity and diabetic complications
    • Teleman A.A., Ratzenbock I., Oldham S. Drosophila: a model for understanding obesity and diabetic complications. Exp Clin Endocrinol Diabetes 2012, 120(4):184-185.
    • (2012) Exp Clin Endocrinol Diabetes , vol.120 , Issue.4 , pp. 184-185
    • Teleman, A.A.1    Ratzenbock, I.2    Oldham, S.3
  • 7
    • 84860350761 scopus 로고    scopus 로고
    • Drosophila as a model to study the genetic mechanisms of obesity-associated heart dysfunction
    • Diop S.B., Bodmer R. Drosophila as a model to study the genetic mechanisms of obesity-associated heart dysfunction. J Cell Mol Med 2012, 16(5):966-971.
    • (2012) J Cell Mol Med , vol.16 , Issue.5 , pp. 966-971
    • Diop, S.B.1    Bodmer, R.2
  • 8
    • 79251646185 scopus 로고    scopus 로고
    • Obesity and nutrient sensing TOR pathway in flies and vertebrates: functional conservation of genetic mechanisms
    • Oldham S. Obesity and nutrient sensing TOR pathway in flies and vertebrates: functional conservation of genetic mechanisms. Trends Endocrinol Metab 2011, 22(2):45-52.
    • (2011) Trends Endocrinol Metab , vol.22 , Issue.2 , pp. 45-52
    • Oldham, S.1
  • 9
    • 77957745581 scopus 로고    scopus 로고
    • Energy homeostasis regulation in Drosophila: a lipocentric perspective
    • Kuhnlein R.P. Energy homeostasis regulation in Drosophila: a lipocentric perspective. Results Probl Cell Differ 2010, 52:159-173. 10.1007/978-3-642-14426-4_13.:159-173.
    • (2010) Results Probl Cell Differ , vol.52 , pp. 159-173
    • Kuhnlein, R.P.1
  • 10
    • 59649094753 scopus 로고    scopus 로고
    • Insulin/TOR signaling in growth and homeostasis: a view from the fly world
    • Grewal S.S. Insulin/TOR signaling in growth and homeostasis: a view from the fly world. Int J Biochem Cell Biol 2009, 41(5):1006-1010.
    • (2009) Int J Biochem Cell Biol , vol.41 , Issue.5 , pp. 1006-1010
    • Grewal, S.S.1
  • 11
    • 37348999201 scopus 로고    scopus 로고
    • Lessons from "lower" organisms: what worms, flies, and zebrafish can teach us about human energy metabolism
    • Schlegel A., Stainier D.Y. Lessons from "lower" organisms: what worms, flies, and zebrafish can teach us about human energy metabolism. PLoS Genet 2007, 3(11):e199.
    • (2007) PLoS Genet , vol.3 , Issue.11 , pp. e199
    • Schlegel, A.1    Stainier, D.Y.2
  • 12
    • 34548847172 scopus 로고    scopus 로고
    • Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila
    • Baker K.D., Thummel C.S. Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila. Cell Metab 2007, 6(4):257-266.
    • (2007) Cell Metab , vol.6 , Issue.4 , pp. 257-266
    • Baker, K.D.1    Thummel, C.S.2
  • 13
    • 27544460718 scopus 로고    scopus 로고
    • Extended longevity and insulin signaling in adipose tissue
    • Kloting N., Bluher M. Extended longevity and insulin signaling in adipose tissue. Exp Gerontol 2005, 40(11):878-883.
    • (2005) Exp Gerontol , vol.40 , Issue.11 , pp. 878-883
    • Kloting, N.1    Bluher, M.2
  • 14
    • 69449105730 scopus 로고    scopus 로고
    • A taste of the Drosophila gustatory receptors
    • Montell C. A taste of the Drosophila gustatory receptors. Curr Opin Neurobiol 2009, 19(4):345-353.
    • (2009) Curr Opin Neurobiol , vol.19 , Issue.4 , pp. 345-353
    • Montell, C.1
  • 15
    • 84869102868 scopus 로고    scopus 로고
    • Fruit fly behavior in response to chemosensory signals
    • Herrero P. Fruit fly behavior in response to chemosensory signals. Peptides 2012, 38(2):228-237.
    • (2012) Peptides , vol.38 , Issue.2 , pp. 228-237
    • Herrero, P.1
  • 16
    • 84876920031 scopus 로고    scopus 로고
    • +/solute co-transporter in Drosophila
    • +/solute co-transporter in Drosophila. Nat Neurosci 2013, 16(5):526-528.
    • (2013) Nat Neurosci , vol.16 , Issue.5 , pp. 526-528
    • Dus, M.1    Ai, M.2    Suh, G.S.3
  • 17
    • 84874586591 scopus 로고    scopus 로고
    • Modeling obesity and its associated disorders in Drosophila
    • Trinh I., Boulianne G.L. Modeling obesity and its associated disorders in Drosophila. Physiology 2013, 28(2):117-124.
    • (2013) Physiology , vol.28 , Issue.2 , pp. 117-124
    • Trinh, I.1    Boulianne, G.L.2
  • 18
    • 10644276290 scopus 로고    scopus 로고
    • Drosophila, the golden bug, emerges as a tool for human genetics
    • Bier E. Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet 2005, 6(1):9-23.
    • (2005) Nat Rev Genet , vol.6 , Issue.1 , pp. 9-23
    • Bier, E.1
  • 19
    • 77949899075 scopus 로고    scopus 로고
    • Flightless flies: Drosophila models of neuromuscular disease
    • [e1-20.:e1-20]
    • Lloyd T.E., Taylor J.P. Flightless flies: Drosophila models of neuromuscular disease. Ann N Y Acad Sci 2010, 1184. [e1-20.:e1-20].
    • (2010) Ann N Y Acad Sci , pp. 1184
    • Lloyd, T.E.1    Taylor, J.P.2
  • 20
    • 79955749505 scopus 로고    scopus 로고
    • Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery
    • Pandey U.B., Nichols C.D. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev 2011, 63(2):411-436.
    • (2011) Pharmacol Rev , vol.63 , Issue.2 , pp. 411-436
    • Pandey, U.B.1    Nichols, C.D.2
  • 21
    • 48349102037 scopus 로고    scopus 로고
    • Developmental biology: our fly cousins' gut
    • Pitsouli C., Perrimon N. Developmental biology: our fly cousins' gut. Nature 2008, 454(7204):592-593.
    • (2008) Nature , vol.454 , Issue.7204 , pp. 592-593
    • Pitsouli, C.1    Perrimon, N.2
  • 22
    • 33947403922 scopus 로고    scopus 로고
    • Genetic dissection of neural circuit anatomy underlying feeding behavior in Drosophila: distinct classes of hugin-expressing neurons
    • Bader R., Colomb J., Pankratz B., Schrock A., Stocker R.F., Pankratz M.J. Genetic dissection of neural circuit anatomy underlying feeding behavior in Drosophila: distinct classes of hugin-expressing neurons. J Comp Neurol 2007, 502(5):848-856.
    • (2007) J Comp Neurol , vol.502 , Issue.5 , pp. 848-856
    • Bader, R.1    Colomb, J.2    Pankratz, B.3    Schrock, A.4    Stocker, R.F.5    Pankratz, M.J.6
  • 23
    • 33846279755 scopus 로고    scopus 로고
    • Specialized hepatocyte-like cells regulate Drosophila lipid metabolism
    • Gutierrez E., Wiggins D., Fielding B., Gould A.P. Specialized hepatocyte-like cells regulate Drosophila lipid metabolism. Nature 2007, 445(7125):275-280.
    • (2007) Nature , vol.445 , Issue.7125 , pp. 275-280
    • Gutierrez, E.1    Wiggins, D.2    Fielding, B.3    Gould, A.P.4
  • 26
    • 3242677215 scopus 로고    scopus 로고
    • Gene expression systems in Drosophila: a synthesis of time and space
    • McGuire S.E., Roman G., Davis R.L. Gene expression systems in Drosophila: a synthesis of time and space. Trends Genet 2004, 20(8):384-391.
    • (2004) Trends Genet , vol.20 , Issue.8 , pp. 384-391
    • McGuire, S.E.1    Roman, G.2    Davis, R.L.3
  • 27
    • 14544279308 scopus 로고    scopus 로고
    • Research resources for Drosophila: the expanding universe
    • Matthews K.A., Kaufman T.C., Gelbart W.M. Research resources for Drosophila: the expanding universe. Nat Rev Genet 2005, 6(3):179-193.
    • (2005) Nat Rev Genet , vol.6 , Issue.3 , pp. 179-193
    • Matthews, K.A.1    Kaufman, T.C.2    Gelbart, W.M.3
  • 28
    • 0036244951 scopus 로고    scopus 로고
    • The art and design of genetic screens: Drosophila melanogaster
    • St J.D. The art and design of genetic screens: Drosophila melanogaster. Nat Rev Genet 2002, 3(3):176-188.
    • (2002) Nat Rev Genet , vol.3 , Issue.3 , pp. 176-188
    • St, J.D.1
  • 29
    • 33745684796 scopus 로고    scopus 로고
    • One hundred years of high-throughput Drosophila research
    • Beller M., Oliver B. One hundred years of high-throughput Drosophila research. Chromosome Res 2006, 14(4):349-362.
    • (2006) Chromosome Res , vol.14 , Issue.4 , pp. 349-362
    • Beller, M.1    Oliver, B.2
  • 30
    • 30844437476 scopus 로고    scopus 로고
    • Signaling and function of insulin-like peptides in insects
    • Wu Q., Brown M.R. Signaling and function of insulin-like peptides in insects. Annu Rev Entomol 2006, 51:1-24.
    • (2006) Annu Rev Entomol , vol.51 , pp. 1-24
    • Wu, Q.1    Brown, M.R.2
  • 32
    • 33845900934 scopus 로고    scopus 로고
    • The cytohesin Steppke is essential for insulin signalling in Drosophila
    • Fuss B., Becker T., Zinke I., Hoch M. The cytohesin Steppke is essential for insulin signalling in Drosophila. Nature 2006, 444(7121):945-948.
    • (2006) Nature , vol.444 , Issue.7121 , pp. 945-948
    • Fuss, B.1    Becker, T.2    Zinke, I.3    Hoch, M.4
  • 33
    • 42249108516 scopus 로고    scopus 로고
    • Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance
    • Honegger B., Galic M., Kohler K., Wittwer F., Brogiolo W., Hafen E., Stocker H. Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance. J Biol 2008, 7(3):10.
    • (2008) J Biol , vol.7 , Issue.3 , pp. 10
    • Honegger, B.1    Galic, M.2    Kohler, K.3    Wittwer, F.4    Brogiolo, W.5    Hafen, E.6    Stocker, H.7
  • 34
    • 34447530305 scopus 로고    scopus 로고
    • A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila
    • Dietzl G., Chen D., Schnorrer F., Su K.C., Barinova Y., Fellner M., et al. A genome-wide transgenic RNAi library for conditional gene inactivation in Drosophila. Nature 2007, 448(7150):151-156.
    • (2007) Nature , vol.448 , Issue.7150 , pp. 151-156
    • Dietzl, G.1    Chen, D.2    Schnorrer, F.3    Su, K.C.4    Barinova, Y.5    Fellner, M.6
  • 35
    • 38049029093 scopus 로고    scopus 로고
    • Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster
    • Chen J., Shi X., Padmanabhan R., Wang Q., Wu Z., Stevenson S.C., et al. Identification of novel modulators of mitochondrial function by a genome-wide RNAi screen in Drosophila melanogaster. Genome Res 2008, 18(1):123-136.
    • (2008) Genome Res , vol.18 , Issue.1 , pp. 123-136
    • Chen, J.1    Shi, X.2    Padmanabhan, R.3    Wang, Q.4    Wu, Z.5    Stevenson, S.C.6
  • 36
    • 44449095056 scopus 로고    scopus 로고
    • Functional genomic screen reveals genes involved in lipid-droplet formation and utilization
    • Guo Y., Walther T.C., Rao M., Stuurman N., Goshima G., Terayama K., et al. Functional genomic screen reveals genes involved in lipid-droplet formation and utilization. Nature 2008, 453(7195):657-661.
    • (2008) Nature , vol.453 , Issue.7195 , pp. 657-661
    • Guo, Y.1    Walther, T.C.2    Rao, M.3    Stuurman, N.4    Goshima, G.5    Terayama, K.6
  • 37
    • 84871024376 scopus 로고    scopus 로고
    • Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model
    • Liu J., Li T., Yang D., Ma R., Moran T.H., Smith W.W. Synphilin-1 alters metabolic homeostasis in a novel Drosophila obesity model. Int J Obes (Lond) 2012, 36(12):1529-1536.
    • (2012) Int J Obes (Lond) , vol.36 , Issue.12 , pp. 1529-1536
    • Liu, J.1    Li, T.2    Yang, D.3    Ma, R.4    Moran, T.H.5    Smith, W.W.6
  • 40
    • 78049425280 scopus 로고    scopus 로고
    • High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila
    • Birse R.T., Choi J., Reardon K., Rodriguez J., Graham S., Diop S., et al. High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila. Cell Metab 2010, 12(5):533-544.
    • (2010) Cell Metab , vol.12 , Issue.5 , pp. 533-544
    • Birse, R.T.1    Choi, J.2    Reardon, K.3    Rodriguez, J.4    Graham, S.5    Diop, S.6
  • 41
    • 84866363269 scopus 로고    scopus 로고
    • A novel obesity model: synphilin-1-induced hyperphagia and obesity in mice
    • Li X., Tamashiro K.L., Liu Z., Bello N.T., Wang X., Aja S., et al. A novel obesity model: synphilin-1-induced hyperphagia and obesity in mice. Int J Obes (Lond) 2012, 36(9):1215-1221.
    • (2012) Int J Obes (Lond) , vol.36 , Issue.9 , pp. 1215-1221
    • Li, X.1    Tamashiro, K.L.2    Liu, Z.3    Bello, N.T.4    Wang, X.5    Aja, S.6
  • 42
    • 84864867757 scopus 로고    scopus 로고
    • Diet-induced obesity: rodent model for the study of obesity-related disorders
    • Rosini T.C., Silva A.S., Moraes C. Diet-induced obesity: rodent model for the study of obesity-related disorders. Rev Assoc Med Bras 2012, 58(3):383-387.
    • (2012) Rev Assoc Med Bras , vol.58 , Issue.3 , pp. 383-387
    • Rosini, T.C.1    Silva, A.S.2    Moraes, C.3
  • 43
    • 36049044765 scopus 로고    scopus 로고
    • Drosophila and the genetics of the internal milieu
    • Leopold P., Perrimon N. Drosophila and the genetics of the internal milieu. Nature 2007, 450(7167):186-188.
    • (2007) Nature , vol.450 , Issue.7167 , pp. 186-188
    • Leopold, P.1    Perrimon, N.2
  • 44
    • 78649701176 scopus 로고    scopus 로고
    • A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability
    • Reis T., Van Gilst M.R., Hariharan I.K. A buoyancy-based screen of Drosophila larvae for fat-storage mutants reveals a role for Sir2 in coupling fat storage to nutrient availability. PLoS Genet 2010, 6(11):e1001206.
    • (2010) PLoS Genet , vol.6 , Issue.11 , pp. e1001206
    • Reis, T.1    Van Gilst, M.R.2    Hariharan, I.K.3
  • 47
    • 34548244121 scopus 로고    scopus 로고
    • Adipose is a conserved dosage-sensitive antiobesity gene
    • Suh J.M., Zeve D., McKay R., Seo J., Salo Z., Li R., et al. Adipose is a conserved dosage-sensitive antiobesity gene. Cell Metab 2007, 6(3):195-207.
    • (2007) Cell Metab , vol.6 , Issue.3 , pp. 195-207
    • Suh, J.M.1    Zeve, D.2    McKay, R.3    Seo, J.4    Salo, Z.5    Li, R.6
  • 48
    • 73349104451 scopus 로고    scopus 로고
    • Pick Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities
    • Zhang H., Liu J., Li C.R., Momen B., Kohanski R.A., Pick Deletion of Drosophila insulin-like peptides causes growth defects and metabolic abnormalities. Proc Natl Acad Sci U S A 2009, 106(46):19617-19622.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , Issue.46 , pp. 19617-19622
    • Zhang, H.1    Liu, J.2    Li, C.R.3    Momen, B.4    Kohanski, R.A.5
  • 49
  • 52
    • 73349130440 scopus 로고    scopus 로고
    • Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate
    • Pospisilik J.A., Schramek D., Schnidar H., Cronin S.J., Nehme N.T., Zhang X., et al. Drosophila genome-wide obesity screen reveals hedgehog as a determinant of brown versus white adipose cell fate. Cell 2010, 140(1):148-160.
    • (2010) Cell , vol.140 , Issue.1 , pp. 148-160
    • Pospisilik, J.A.1    Schramek, D.2    Schnidar, H.3    Cronin, S.J.4    Nehme, N.T.5    Zhang, X.6
  • 53
    • 84863020848 scopus 로고    scopus 로고
    • Genome-wide screens for gene products regulating lipid droplet dynamics
    • Fei W., Yang H. Genome-wide screens for gene products regulating lipid droplet dynamics. Methods Cell Biol 2012, 108:303-316. 10.1016/B978-0-12-386487-1.00014-6.:303-316.
    • (2012) Methods Cell Biol , vol.108 , pp. 303-316
    • Fei, W.1    Yang, H.2
  • 54
    • 84893508942 scopus 로고    scopus 로고
    • A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity
    • Baumbach J., Hummel P., Bickmeyer I., Kowalczyk K.M., Frank M., Knorr K., et al. A Drosophila in vivo screen identifies store-operated calcium entry as a key regulator of adiposity. Cell Metab 2014, 19(2):331-343.
    • (2014) Cell Metab , vol.19 , Issue.2 , pp. 331-343
    • Baumbach, J.1    Hummel, P.2    Bickmeyer, I.3    Kowalczyk, K.M.4    Frank, M.5    Knorr, K.6
  • 55
    • 41849119497 scopus 로고    scopus 로고
    • A brief introduction to FOXOlogy
    • Burgering B.M. A brief introduction to FOXOlogy. Oncogene 2008, 27(16):2258-2262.
    • (2008) Oncogene , vol.27 , Issue.16 , pp. 2258-2262
    • Burgering, B.M.1
  • 56
    • 33646538482 scopus 로고    scopus 로고
    • The TOR signalling network from yeast to man
    • De V.C., Loewith R. The TOR signalling network from yeast to man. Int J Biochem Cell Biol 2006, 38(9):1476-1481.
    • (2006) Int J Biochem Cell Biol , vol.38 , Issue.9 , pp. 1476-1481
    • De, V.C.1    Loewith, R.2
  • 57
    • 0037306190 scopus 로고    scopus 로고
    • Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control
    • Oldham S., Hafen E. Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control. Trends Cell Biol 2003, 13(2):79-85.
    • (2003) Trends Cell Biol , vol.13 , Issue.2 , pp. 79-85
    • Oldham, S.1    Hafen, E.2
  • 59
    • 60449114381 scopus 로고    scopus 로고
    • Humana Press, Totowa, C. Dahmann (Ed.)
    • Drosophila: methods and protocols 2008, Humana Press, Totowa. C. Dahmann (Ed.).
    • (2008) Drosophila: methods and protocols
  • 60
    • 84860600817 scopus 로고    scopus 로고
    • Analysis of feeding behavior of Drosophila larvae on liquid food
    • Cold Spring Harbor Laboratory Press
    • Shen Ping Analysis of feeding behavior of Drosophila larvae on liquid food. Cold Spring Harb Protoc 2013, Cold Spring Harbor Laboratory Press. 10.1101/pdb.prot069310.
    • (2013) Cold Spring Harb Protoc
    • Shen, P.1
  • 61
    • 84860592411 scopus 로고    scopus 로고
    • Analysis of Feeding Behavior of Drosophila Larvae on Solid Food
    • Cold Spring Harbor Laboratory Press
    • Shen Ping Analysis of Feeding Behavior of Drosophila Larvae on Solid Food. Cold Spring Harb Protoc 2013, Cold Spring Harbor Laboratory Press. 10.1101/pdb.prot069328.
    • (2013) Cold Spring Harb Protoc
    • Shen, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.