A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila

DMM Disease Models and Mechanisms

Volumn 4, Issue 6, 2011, Pages 842-849

  Musselman, Laura Palanker ^a   Fink, Jill L ^a   Narzinski, Kirk ^a   Ramachandran, Prasanna Venkatesh ^a   Hathiramani, Sumitha Sukumar ^a   Cagan, Ross L ^b   Baranski, Thomas J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRIACYLGLYCEROL;

ARTICLE; CARBOHYDRATE METABOLISM; DROSOPHILA MELANOGASTER; FATTY ACID OXIDATION; GLUCONEOGENESIS; HYPERGLYCEMIA; INSULIN RESISTANCE; LARVA; LIPOGENESIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUGAR INTAKE;

ANIMALS; CARBOHYDRATE METABOLISM; DIET; DIETARY CARBOHYDRATES; DROSOPHILA MELANOGASTER; FEEDING BEHAVIOR; GENE EXPRESSION REGULATION; HYPERGLYCEMIA; INSULIN RESISTANCE; LIPID METABOLISM; OBESITY; TRANSCRIPTION, GENETIC;

DROSOPHILA MELANOGASTER;

EID: 81455136679     PISSN: 17548403     EISSN: 17548411     Source Type: Journal    
DOI: 10.1242/dmm.007948     Document Type: Article

References (41)

1. Baker, K. D. and Thummel, C. S. (2007). Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila. Cell Metab. 6, 257-266. (Pubitemid 47450188)
2. Beissbarth, T. and Speed, T. P. (2004). GOstat: find statistically overrepresented Gene Ontologies within a group of genes. Bioinformatics 20, 1464-1465. (Pubitemid 38931420)
3. Bohni, R., Riesgo-Escovar, J., Oldham, S., Brogiolo, W., Stocker, H., Andruss, B. F., Beckingham, K. and Hafen, E. (1999). Autonomous control of cell and organ size by CHICO, a Drosophila homolog of vertebrate IRS1-4. Cell 97, 865-875. (Pubitemid 29375046)
4. Brookheart, R. T., Michel, C. I. and Schaffer, J. E. (2009). As a matter of fat. Cell Metab. 10, 9-12.
5. Broughton, S. J., Piper, M. D., Ikeya, T., Bass, T. M., Jacobson, J., Driege, Y., Martinez, P., Hafen, E., Withers, D. J., Leevers, S. J. et al. (2005). Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc. Natl. Acad. Sci. USA 102, 3105-3110. (Pubitemid 40299923)
6. Buch, S., Melcher, C., Bauer, M., Katzenberger, J. and Pankratz, M. J. (2008). Opposing effects of dietary protein and sugar regulate a transcriptional target of Drosophila insulin-like peptide signaling. Cell Metab. 7, 321-332. (Pubitemid 351455218)
7. Carsten, L. D., Watts, T. and Markow, T. A. (2005). Gene expression patterns accompanying a dietary shift in Drosophila melanogaster. Mol. Ecol. 14, 3203-3208.
8. Ceddia, R. B., Bikopoulos, G. J., Hilliker, A. J. and Sweeney, G. (2003). Insulin stimulates glucose metabolism via the pentose phosphate pathway in Drosophila Kc cells. FEBS Lett. 555, 307-310. (Pubitemid 37486046)
9. Chen, C., Jack, J. and Garofalo, R. S. (1996). The Drosophila insulin receptor is required for normal growth. Endocrinology 137, 846-856. (Pubitemid 26070364)
10. Fukuchi, S., Hamaguchi, K., Seike, M., Himeno, K., Sakata, T. and Yoshimatsu, H. (2004). Role of fatty acid composition in the development of metabolic disorders in sucrose-induced obese rats. Exp. Biol. Med. (Maywood) 229, 486-493. (Pubitemid 38736317)
11. Geminard, C., Rulifson, E. J. and Leopold, P. (2009). Remote control of insulin secretion by fat cells in Drosophila. Cell Metab. 10, 199-207.
12. Guan, H. P., Li, Y., Jensen, M. V., Newgard, C. B., Steppan, C. M. and Lazar, M. A. (2002). A futile metabolic cycle activated in adipocytes by antidiabetic agents. Nat. Med. 8, 1122-1128. (Pubitemid 35175967)
13. Holland, W. L., Brozinick, J. T., Wang, L. P., Hawkins, E. D., Sargent, K. M., Liu, Y., Narra, K., Hoehn, K. L., Knotts, T. A., Siesky, A. et al. (2007). Inhibition of ceramide synthesis ameliorates glucocorticoid-, saturated-fat-, and obesity-induced insulin resistance. Cell Metab. 5, 167-179.
14. Honegger, B., Galic, M., Kohler, K., Wittwer, F., Brogiolo, W., Hafen, E. and Stocker, H. (2008). Imp-L2, a putative homolog of vertebrate IGF-binding protein 7, counteracts insulin signaling in Drosophila and is essential for starvation resistance. J. Biol. 7, 10.
15. Junkin, K. A., Dyck, D. J., Mullen, K. L., Chabowski, A. and Thrush, A. B. (2009). Resistin acutely impairs insulin-stimulated glucose transport in rodent muscle in the presence, but not absence, of palmitate. Am. J. Physiol. Regul. Integr. Comp. Physiol. 296, R944-R951.
16. Kim, S. K. and Rulifson, E. J. (2004). Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells. Nature 431, 316-320. (Pubitemid 39265667)
17. Krishnan, S., Rosenberg, L., Singer, M., Hu, F. B., Djousse, L., Cupples, L. A. and Palmer, J. R. (2007). Glycemic index, glycemic load, and cereal fiber intake and risk of type 2 diabetes in US black women. Arch. Intern. Med. 167, 2304-2309. (Pubitemid 350179524)
18. Lee, G. and Park, J. H. (2004). Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormoneencoding gene in Drosophila melanogaster. Genetics 167, 311-323. (Pubitemid 38736390)
19. Lee, S. S., Kennedy, S., Tolonen, A. C. and Ruvkun, G. (2003). DAF-16 target genes that control C. elegans life-span and metabolism. Science 300, 644-647. (Pubitemid 36520589)
20. Leiter, E. H., Coleman, D. L., Ingram, D. K. and Reynolds, M. A. (1983). Influence of dietary carbohydrate on the induction of diabetes in C57BL/KsJ-db/db diabetes mice. J. Nutr. 113, 184-195. (Pubitemid 13130663)
21. Li, C. and Hung Wong, W. (2001). Model-based analysis of oligonucleotide arrays: model validation, design issues and standard error application. Genome Biol. 2, RESEARCH0032.
22. Livesey, G., Taylor, R., Hulshof, T. and Howlett, J. (2008). Glycemic response and health-a systematic review and meta-analysis: the database, study characteristics, and macronutrient intakes. Am. J. Clin. Nutr. 87, 223S-236S.
23. Lusis, A. J., Attie, A. D. and Reue, K. (2008). Metabolic syndrome: from epidemiology to systems biology. Nat. Rev. Genet. 9, 819-830.
24. Marshall, B. A., Tordjman, K., Host, H. H., Ensor, N. J., Kwon, G., Marshall, C. A., Coleman, T., McDaniel, M. L. and Semenkovich, C. F. (1999). Relative hypoglycemia and hyperinsulinemia in mice with heterozygous lipoprotein lipase (LPL) deficiency. Islet LPL regulates insulin secretion. J. Biol. Chem. 274, 27426-27432.
25. Michael, M. D., Kulkarni, R. N., Postic, C., Previs, S. F., Shulman, G. I., Magnuson, M. A. and Kahn, C. R. (2000). Loss of insulin signaling in hepatocytes leads to severe insulin resistance and progressive hepatic dysfunction. Mol. Cell 6, 87-97.
26. Mokdad, A. H., Ford, E. S., Bowman, B. A., Dietz, W. H., Vinicor, F., Bales, V. S. and Marks, J. S. (2003). Prevalence of obesity, diabetes, and obesity-related health risk factors, 2001. JAMA 289, 76-79. (Pubitemid 36026281)
27. Muoio, D. M. and Newgard, C. B. (2008). Mechanisms of disease: molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat. Rev. Mol. Cell Biol. 9, 193-205. (Pubitemid 351301824)
28. O'Brien, R. M., Lucas, P. C., Forest, C. D., Magnuson, M. A. and Granner, D. K. (1990). Identification of a sequence in the PEPCK gene that mediates a negative effect of insulin on transcription. Science 249, 533-537.
29. Randle, P. J., Garland, P. B., Hales, C. N. and Newsholme, E. A. (1963). The glucose fatty-acid cycle. Its role in insulin sensitivity and the metabolic disturbances of diabetes mellitus. Lancet 1, 785-789.
30. Reed, L. K., Williams, S., Springston, M., Brown, J., Freeman, K., DesRoches, C. E., Sokolowski, M. B. and Gibson, G. (2010). Genotype-by-diet interactions drive metabolic phenotype variation in Drosophila melanogaster. Genetics 185, 1009-1019.
31. Rulifson, E. J., Kim, S. K. and Nusse, R. (2002). Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science 296, 1118-1120. (Pubitemid 34517128)
32. Salans, L. B., Bray, G. A., Cushman, S. W., Danforth, E., Jr, Glennon, J. A., Horton, E. S. and Sims, E. A. (1974). Glucose metabolism and the response to insulin by human adipose tissue in spontaneous and experimental obesity. Effects of dietary composition and adipose cell size. J. Clin. Invest. 53, 848-856.
33. Samuel, V. T., Beddow, S. A., Iwasaki, T., Zhang, X. M., Chu, X., Still, C. D., Gerhard, G. S. and Shulman, G. I. (2009). Fasting hyperglycemia is not associated with increased expression of PEPCK or G6Pc in patients with Type 2 Diabetes. Proc. Natl. Acad. Sci. USA 106, 12121-12126.
34. Sheard, N. F., Clark, N. G., Brand-Miller, J. C., Franz, M. J., Pi-Sunyer, F. X., Mayer- Davis, E., Kulkarni, K. and Geil, P. (2004). Dietary carbohydrate (amount and type) in the prevention and management of diabetes: a statement by the American Diabetes Association. Diabetes Care 27, 2266-2271. (Pubitemid 39167201)
35. Shingleton, A. W., Das, J., Vinicius, L. and Stern, D. L. (2005). The temporal requirements for insulin signaling during development in Drosophila. PLoS Biol. 3, e289.
36. Skorupa, D. A., Dervisefendic, A., Zwiener, J. and Pletcher, S. D. (2008). Dietary composition specifies consumption, obesity, and lifespan in Drosophila melanogaster. Aging Cell 7, 478-490. (Pubitemid 351998608)
37. Song, W., Ren, D., Li, W., Jiang, L., Cho, K. W., Huang, P., Fan, C., Song, Y., Liu, Y. and Rui, L. (2010). SH2B regulation of growth, metabolism, and longevity in both insects and mammals. Cell Metab. 11, 427-437.
38. Tusher, V. G., Tibshirani, R. and Chu, G. (2001). Significance analysis of microarrays applied to the ionizing radiation response. Proc. Natl. Acad. Sci. USA 98, 5116-5121. (Pubitemid 32397092)
39. Villegas, R., Liu, S., Gao, Y. T., Yang, G., Li, H., Zheng, W. and Shu, X. O. (2007). Prospective study of dietary carbohydrates, glycemic index, glycemic load, and incidence of type 2 diabetes mellitus in middle-aged Chinese women. Arch. Intern. Med. 167, 2310-2316. (Pubitemid 350179525)
40. Wild, S., Roglic, G., Green, A., Sicree, R. and King, H. (2004). Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 27, 1047-1053. (Pubitemid 38579764)
41. Yu, C., Chen, Y., Cline, G. W., Zhang, D., Zong, H., Wang, Y., Bergeron, R., Kim, J. K., Cushman, S. W., Cooney, G. J. et al. (2002). Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J. Biol. Chem. 277, 50230-50236. (Pubitemid 36042170)