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Volumn 12, Issue 5, 2010, Pages 533-544

High-fat-diet-induced obesity and heart dysfunction are regulated by the TOR pathway in Drosophila

Author keywords

[No Author keywords available]

Indexed keywords

DROSOPHILA PROTEIN; INITIATION FACTOR 4E BINDING PROTEIN; INSULIN; PROTEIN TCS1; PROTEIN TCS2; TOLL LIKE RECEPTOR; TRANSCRIPTION FACTOR FOXO; TRIACYLGLYCEROL; TRIACYLGLYCEROL LIPASE; UNCLASSIFIED DRUG;

EID: 78049425280     PISSN: 15504131     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cmet.2010.09.014     Document Type: Article
Times cited : (293)

References (59)
  • 1
    • 14844345016 scopus 로고    scopus 로고
    • Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity
    • D.E. Arking, G. Atzmon, A. Arking, N. Barzilai, and H.C. Dietz Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity Circ. Res. 96 2005 412 418
    • (2005) Circ. Res. , vol.96 , pp. 412-418
    • Arking, D.E.1    Atzmon, G.2    Arking, A.3    Barzilai, N.4    Dietz, H.C.5
  • 2
    • 34548847172 scopus 로고    scopus 로고
    • Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila
    • K.D. Baker, and C.S. Thummel Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila Cell Metab. 6 2007 257 266
    • (2007) Cell Metab. , vol.6 , pp. 257-266
    • Baker, K.D.1    Thummel, C.S.2
  • 4
    • 0036068133 scopus 로고    scopus 로고
    • Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance
    • M. Bluher, M.D. Michael, O.D. Peroni, K. Ueki, N. Carter, B.B. Kahn, and C.R. Kahn Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance Dev. Cell 3 2002 25 38
    • (2002) Dev. Cell , vol.3 , pp. 25-38
    • Bluher, M.1    Michael, M.D.2    Peroni, O.D.3    Ueki, K.4    Carter, N.5    Kahn, B.B.6    Kahn, C.R.7
  • 5
    • 0028959673 scopus 로고
    • Heart development in Drosophila and its relationship to vertebrate systems
    • R. Bodmer Heart development in Drosophila and its relationship to vertebrate systems Trends Cardiovasc. Med. 5 1995 21 28
    • (1995) Trends Cardiovasc. Med. , vol.5 , pp. 21-28
    • Bodmer, R.1
  • 6
    • 0031805934 scopus 로고    scopus 로고
    • Heart development in Drosophila and vertebrates: Conservation of molecular mechanisms
    • R. Bodmer, and T.V. Venkatesh Heart development in Drosophila and vertebrates: conservation of molecular mechanisms Dev. Genet. 22 1998 181 186
    • (1998) Dev. Genet. , vol.22 , pp. 181-186
    • Bodmer, R.1    Venkatesh, T.V.2
  • 7
    • 0027160708 scopus 로고
    • Targeted gene expression as a means of altering cell fates and generating dominant phenotypes
    • A.H. Brand, and N. Perrimon Targeted gene expression as a means of altering cell fates and generating dominant phenotypes Development 118 1993 401 415
    • (1993) Development , vol.118 , pp. 401-415
    • Brand, A.H.1    Perrimon, N.2
  • 8
    • 39449118905 scopus 로고    scopus 로고
    • Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles
    • A. Cammarato, C.M. Dambacher, A.F. Knowles, W.A. Kronert, R. Bodmer, K. Ocorr, and S.I. Bernstein Myosin transducer mutations differentially affect motor function, myofibril structure, and the performance of skeletal and cardiac muscles Mol. Biol. Cell 19 2008 553 562
    • (2008) Mol. Biol. Cell , vol.19 , pp. 553-562
    • Cammarato, A.1    Dambacher, C.M.2    Knowles, A.F.3    Kronert, W.A.4    Bodmer, R.5    Ocorr, K.6    Bernstein, S.I.7
  • 9
    • 0037262925 scopus 로고    scopus 로고
    • EcR isoforms in Drosophila: Testing tissue-specific requirements by targeted blockade and rescue
    • L. Cherbas, X. Hu, I. Zhimulev, E. Belyaeva, and P. Cherbas EcR isoforms in Drosophila: testing tissue-specific requirements by targeted blockade and rescue Development 130 2003 271 284
    • (2003) Development , vol.130 , pp. 271-284
    • Cherbas, L.1    Hu, X.2    Zhimulev, I.3    Belyaeva, E.4    Cherbas, P.5
  • 11
    • 0036608009 scopus 로고    scopus 로고
    • Control of cardiac development by an evolutionarily conserved transcriptional network
    • R.M. Cripps, and E.N. Olson Control of cardiac development by an evolutionarily conserved transcriptional network Dev. Biol. 246 2002 14 28
    • (2002) Dev. Biol. , vol.246 , pp. 14-28
    • Cripps, R.M.1    Olson, E.N.2
  • 12
    • 54049155806 scopus 로고    scopus 로고
    • Hypertrophic cardiomyopathy in high-fat diet-induced obesity: Role of suppression of forkhead transcription factor and atrophy gene transcription
    • C.X. Fang, F. Dong, D.P. Thomas, H. Ma, L. He, and J. Ren Hypertrophic cardiomyopathy in high-fat diet-induced obesity: role of suppression of forkhead transcription factor and atrophy gene transcription Am. J. Physiol. Heart Circ. Physiol. 295 2008 H1206 H1215
    • (2008) Am. J. Physiol. Heart Circ. Physiol. , vol.295
    • Fang, C.X.1    Dong, F.2    Thomas, D.P.3    Ma, H.4    He, L.5    Ren, J.6
  • 13
    • 0037417725 scopus 로고    scopus 로고
    • A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: Modulation by dietary fat content
    • B.N. Finck, X. Han, M. Courtois, F. Aimond, J.M. Nerbonne, A. Kovacs, R.W. Gross, and D.P. Kelly A critical role for PPARalpha-mediated lipotoxicity in the pathogenesis of diabetic cardiomyopathy: modulation by dietary fat content Proc. Natl. Acad. Sci. USA 100 2003 1226 1231
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 1226-1231
    • Finck, B.N.1    Han, X.2    Courtois, M.3    Aimond, F.4    Nerbonne, J.M.5    Kovacs, A.6    Gross, R.W.7    Kelly, D.P.8
  • 15
    • 20144366852 scopus 로고    scopus 로고
    • Rapid iterative negative geotaxis (RING): A new method for assessing age-related locomotor decline in Drosophila
    • J.W. Gargano, I. Martin, P. Bhandari, and M.S. Grotewiel Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in Drosophila Exp. Gerontol. 40 2005 386 395
    • (2005) Exp. Gerontol. , vol.40 , pp. 386-395
    • Gargano, J.W.1    Martin, I.2    Bhandari, P.3    Grotewiel, M.S.4
  • 19
    • 33645739371 scopus 로고    scopus 로고
    • Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis
    • Z. Han, P. Yi, X. Li, and E.N. Olson Hand, an evolutionarily conserved bHLH transcription factor required for Drosophila cardiogenesis and hematopoiesis Development 133 2006 1175 1182
    • (2006) Development , vol.133 , pp. 1175-1182
    • Han, Z.1    Yi, P.2    Li, X.3    Olson, E.N.4
  • 20
    • 0030587603 scopus 로고    scopus 로고
    • NK-2 homeobox genes and heart development
    • R.P. Harvey NK-2 homeobox genes and heart development Dev. Biol. 178 1996 203 216
    • (1996) Dev. Biol. , vol.178 , pp. 203-216
    • Harvey, R.P.1
  • 21
    • 0036742659 scopus 로고    scopus 로고
    • Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila
    • K.M. Hennig, and T.P. Neufeld Inhibition of cellular growth and proliferation by dTOR overexpression in Drosophila Genesis 34 2002 107 110
    • (2002) Genesis , vol.34 , pp. 107-110
    • Hennig, K.M.1    Neufeld, T.P.2
  • 23
    • 4644242353 scopus 로고    scopus 로고
    • Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
    • S.K. Kim, and E.J. Rulifson Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells Nature 431 2004 316 320
    • (2004) Nature , vol.431 , pp. 316-320
    • Kim, S.K.1    Rulifson, E.J.2
  • 25
    • 77649251207 scopus 로고    scopus 로고
    • MTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis
    • M. Laplante, and D.M. Sabatini mTORC1 activates SREBP-1c and uncouples lipogenesis from gluconeogenesis Proc. Natl. Acad. Sci. USA 107 2010 3281 3282
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 3281-3282
    • Laplante, M.1    Sabatini, D.M.2
  • 27
    • 36049044765 scopus 로고    scopus 로고
    • Drosophila and the genetics of the internal milieu
    • P. Leopold, and N. Perrimon Drosophila and the genetics of the internal milieu Nature 450 2007 186 188
    • (2007) Nature , vol.450 , pp. 186-188
    • Leopold, P.1    Perrimon, N.2
  • 28
    • 77649264504 scopus 로고    scopus 로고
    • Bifurcation of insulin signaling pathway in rat liver: MTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis
    • S. Li, M.S. Brown, and J.L. Goldstein Bifurcation of insulin signaling pathway in rat liver: mTORC1 required for stimulation of lipogenesis, but not inhibition of gluconeogenesis Proc. Natl. Acad. Sci. USA 107 2010 3441 3446
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 3441-3446
    • Li, S.1    Brown, M.S.2    Goldstein, J.L.3
  • 30
    • 8444224619 scopus 로고    scopus 로고
    • Balancing Akt with S6K: Implications for both metabolic diseases and tumorigenesis
    • B.D. Manning Balancing Akt with S6K: implications for both metabolic diseases and tumorigenesis J. Cell Biol. 167 2004 399 403
    • (2004) J. Cell Biol. , vol.167 , pp. 399-403
    • Manning, B.D.1
  • 31
    • 0034976004 scopus 로고    scopus 로고
    • The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila
    • M. Miron, J. Verdu, P.E. Lachance, M.J. Birnbaum, P.F. Lasko, and N. Sonenberg The translational inhibitor 4E-BP is an effector of PI(3)K/Akt signalling and cell growth in Drosophila Nat. Cell Biol. 3 2001 596 601
    • (2001) Nat. Cell Biol. , vol.3 , pp. 596-601
    • Miron, M.1    Verdu, J.2    Lachance, P.E.3    Birnbaum, M.J.4    Lasko, P.F.5    Sonenberg, N.6
  • 32
    • 0032453237 scopus 로고    scopus 로고
    • Type II diabetes, essential hypertension, and obesity as "syndromes of impaired genetic homeostasis": The "thrifty genotype" hypothesis enters the 21st century
    • J.V. Neel, A.B. Weder, and S. Julius Type II diabetes, essential hypertension, and obesity as "syndromes of impaired genetic homeostasis": the "thrifty genotype" hypothesis enters the 21st century Perspect. Biol. Med. 42 1998 44 74
    • (1998) Perspect. Biol. Med. , vol.42 , pp. 44-74
    • Neel, J.V.1    Weder, A.B.2    Julius, S.3
  • 34
    • 33846176040 scopus 로고    scopus 로고
    • Age-related cardiac disease model of Drosophila
    • K. Ocorr, T. Akasaka, and R. Bodmer Age-related cardiac disease model of Drosophila Mech. Ageing Dev. 128 2007 112 116
    • (2007) Mech. Ageing Dev. , vol.128 , pp. 112-116
    • Ocorr, K.1    Akasaka, T.2    Bodmer, R.3
  • 36
    • 36848999524 scopus 로고    scopus 로고
    • Genetic variation for cardiac dysfunction in Drosophila
    • K.A. Ocorr, T. Crawley, G. Gibson, and R. Bodmer Genetic variation for cardiac dysfunction in Drosophila PLoS ONE 2 2007 e601 10.1371/journal.pone. 0000601
    • (2007) PLoS ONE , vol.2 , pp. 601
    • Ocorr, K.A.1    Crawley, T.2    Gibson, G.3    Bodmer, R.4
  • 37
    • 0037306190 scopus 로고    scopus 로고
    • Insulin/IGF and target of rapamycin signaling: A TOR de force in growth control
    • S. Oldham, and E. Hafen Insulin/IGF and target of rapamycin signaling: a TOR de force in growth control Trends Cell Biol. 13 2003 79 85
    • (2003) Trends Cell Biol. , vol.13 , pp. 79-85
    • Oldham, S.1    Hafen, E.2
  • 38
    • 21344455935 scopus 로고    scopus 로고
    • Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats
    • D.M. Ouwens, C. Boer, M. Fodor, P. de Galan, R.J. Heine, J.A. Maassen, and M. Diamant Cardiac dysfunction induced by high-fat diet is associated with altered myocardial insulin signalling in rats Diabetologia 48 2005 1229 1237
    • (2005) Diabetologia , vol.48 , pp. 1229-1237
    • Ouwens, D.M.1    Boer, C.2    Fodor, M.3    De Galan, P.4    Heine, R.J.5    Maassen, J.A.6    Diamant, M.7
  • 39
    • 60649099790 scopus 로고    scopus 로고
    • Drosophila HNF4 regulates lipid mobilization and beta-oxidation
    • L. Palanker, J.M. Tennessen, G. Lam, and C.S. Thummel Drosophila HNF4 regulates lipid mobilization and beta-oxidation Cell Metab. 9 2009 228 239
    • (2009) Cell Metab. , vol.9 , pp. 228-239
    • Palanker, L.1    Tennessen, J.M.2    Lam, G.3    Thummel, C.S.4
  • 41
    • 0043172415 scopus 로고    scopus 로고
    • The SREBP pathway - Insights from Insigs and insects
    • R.B. Rawson The SREBP pathway - insights from Insigs and insects Nat. Rev. Mol. Cell Biol. 4 2003 631 640
    • (2003) Nat. Rev. Mol. Cell Biol. , vol.4 , pp. 631-640
    • Rawson, R.B.1
  • 42
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • A.R. Saltiel, and C.R. Kahn Insulin signalling and the regulation of glucose and lipid metabolism Nature 414 2001 799 806
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 43
    • 0038509036 scopus 로고    scopus 로고
    • Lipotoxicity: When tissues overeat
    • J.E. Schaffer Lipotoxicity: when tissues overeat Curr. Opin. Lipidol. 14 2003 281 287
    • (2003) Curr. Opin. Lipidol. , vol.14 , pp. 281-287
    • Schaffer, J.E.1
  • 44
    • 2142829558 scopus 로고    scopus 로고
    • Therapeutic lifestyle changes in the management of obesity
    • J.R. Sowers Therapeutic lifestyle changes in the management of obesity Endocr. Pract. 9 Suppl 2 2003 97 98
    • (2003) Endocr. Pract. , vol.9 , Issue.SUPPL. 2 , pp. 97-98
    • Sowers, J.R.1
  • 47
    • 0037470501 scopus 로고    scopus 로고
    • The endocrine regulation of aging by insulin-like signals
    • M. Tatar, A. Bartke, and A. Antebi The endocrine regulation of aging by insulin-like signals Science 299 2003 1346 1351
    • (2003) Science , vol.299 , pp. 1346-1351
    • Tatar, M.1    Bartke, A.2    Antebi, A.3
  • 48
    • 0345374579 scopus 로고    scopus 로고
    • Minireview: Weapons of lean body mass destruction: The role of ectopic lipids in the metabolic syndrome
    • R.H. Unger Minireview: weapons of lean body mass destruction: the role of ectopic lipids in the metabolic syndrome Endocrinology 144 2003 5159 5165
    • (2003) Endocrinology , vol.144 , pp. 5159-5165
    • Unger, R.H.1
  • 50
    • 33845914986 scopus 로고    scopus 로고
    • Mechanisms linking obesity with cardiovascular disease
    • L.F. Van Gaal, I.L. Mertens, and C.E. De Block Mechanisms linking obesity with cardiovascular disease Nature 444 2006 875 880
    • (2006) Nature , vol.444 , pp. 875-880
    • Van Gaal, L.F.1    Mertens, I.L.2    De Block, C.E.3
  • 51
    • 42949116365 scopus 로고    scopus 로고
    • Lipid accumulation in non-adipose tissue and lipotoxicity
    • N.A. van Herpen, and V.B. Schrauwen-Hinderling Lipid accumulation in non-adipose tissue and lipotoxicity Physiol. Behav. 94 2008 231 241
    • (2008) Physiol. Behav. , vol.94 , pp. 231-241
    • Van Herpen, N.A.1    Schrauwen-Hinderling, V.B.2
  • 53
    • 80055115988 scopus 로고    scopus 로고
    • Visualizing the beating heart in Drosophila
    • 10.3791/1425
    • G. Vogler, and K. Ocorr Visualizing the beating heart in Drosophila J. Vis. Exp. 2009 10.3791/1425
    • (2009) J. Vis. Exp.
    • Vogler, G.1    Ocorr, K.2
  • 54
    • 25444529050 scopus 로고    scopus 로고
    • AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism
    • P. Wang, Y. Zhang, H. Li, H.K. Chieu, A.L. Munn, and H. Yang AAA ATPases regulate membrane association of yeast oxysterol binding proteins and sterol metabolism EMBO J. 24 2005 2989 2999
    • (2005) EMBO J. , vol.24 , pp. 2989-2999
    • Wang, P.1    Zhang, Y.2    Li, H.3    Chieu, H.K.4    Munn, A.L.5    Yang, H.6
  • 55
    • 34848926300 scopus 로고    scopus 로고
    • Epidemiological studies of physical activity and diabetes risk, and implications for diabetes prevention
    • N.J. Wareham Epidemiological studies of physical activity and diabetes risk, and implications for diabetes prevention Appl. Physiol. Nutr. Metab. 32 2007 778 782
    • (2007) Appl. Physiol. Nutr. Metab. , vol.32 , pp. 778-782
    • Wareham, N.J.1
  • 58
    • 0038801547 scopus 로고    scopus 로고
    • Cardiogenesis in the Drosophila model: Control mechanisms during early induction and diversification of cardiac progenitors
    • S. Zaffran, X. Xu, P.C. Lo, H.H. Lee, and M. Frasch Cardiogenesis in the Drosophila model: control mechanisms during early induction and diversification of cardiac progenitors Cold Spring Harb. Symp. Quant. Biol. 67 2002 1 12
    • (2002) Cold Spring Harb. Symp. Quant. Biol. , vol.67 , pp. 1-12
    • Zaffran, S.1    Xu, X.2    Lo, P.C.3    Lee, H.H.4    Frasch, M.5
  • 59


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