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Volumn 16, Issue 5, 2012, Pages 966-971

Drosophila as a model to study the genetic mechanisms of obesity-associated heart dysfunction

Author keywords

Genetic control; Heart dysfunction; Obesity; Triglycerides

Indexed keywords

ANIMAL; DISEASE MODEL; DROSOPHILA MELANOGASTER; GENETICS; HEART DISEASE; LIPID DIET; OBESITY; REVIEW; SIGNAL TRANSDUCTION;

EID: 84860350761     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2012.01522.x     Document Type: Review
Times cited : (41)

References (46)
  • 1
    • 67249137862 scopus 로고    scopus 로고
    • Vertebrate animal models unravel physiological roles for zonula occludens tight junction adaptor proteins
    • Hunziker W, Kiener TK, Xu J. Vertebrate animal models unravel physiological roles for zonula occludens tight junction adaptor proteins. Ann N Y Acad Sci. 2009; 1165: 28-33.
    • (2009) Ann N Y Acad Sci. , vol.1165 , pp. 28-33
    • Hunziker, W.1    Kiener, T.K.2    Xu, J.3
  • 2
    • 38449112356 scopus 로고    scopus 로고
    • Amphibians as animal models for laboratory research in physiology
    • Burggren WW, Warburton S. Amphibians as animal models for laboratory research in physiology. ILAR J. 2007; 48: 260-9.
    • (2007) ILAR J. , vol.48 , pp. 260-269
    • Burggren, W.W.1    Warburton, S.2
  • 3
    • 34247186766 scopus 로고    scopus 로고
    • Animal models of human disease: zebrafish swim into view
    • Lieschke GJ, Currie PD. Animal models of human disease: zebrafish swim into view. Nat Rev Genet. 2007; 8: 353-67.
    • (2007) Nat Rev Genet. , vol.8 , pp. 353-367
    • Lieschke, G.J.1    Currie, P.D.2
  • 4
    • 79951510370 scopus 로고    scopus 로고
    • The contribution of lower vertebrate animal models in human reproduction research
    • Chianese R, Chioccarelli T, Cacciola G, et al. The contribution of lower vertebrate animal models in human reproduction research. Gen Comp Endocrinol. 2011; 171: 17-27.
    • (2011) Gen Comp Endocrinol. , vol.171 , pp. 17-27
    • Chianese, R.1    Chioccarelli, T.2    Cacciola, G.3
  • 6
    • 23144434969 scopus 로고    scopus 로고
    • Using Drosophila melanogaster to map human cancer pathways
    • Brumby AM, Richardson HE. Using Drosophila melanogaster to map human cancer pathways. Nat Rev Cancer. 2005; 5: 626-39.
    • (2005) Nat Rev Cancer. , vol.5 , pp. 626-639
    • Brumby, A.M.1    Richardson, H.E.2
  • 7
    • 33745223646 scopus 로고    scopus 로고
    • Finding function in novel targets: C. elegans as a model organism
    • Kaletta T, Hengartner MO. Finding function in novel targets: C. elegans as a model organism. Nat Rev Drug Discov. 2006; 5: 387-98.
    • (2006) Nat Rev Drug Discov. , vol.5 , pp. 387-398
    • Kaletta, T.1    Hengartner, M.O.2
  • 8
    • 34248598584 scopus 로고    scopus 로고
    • Invertebrate animal models of diseases as screening tools in drug discovery
    • Segalat L. Invertebrate animal models of diseases as screening tools in drug discovery. ACS Chem Biol. 2007; 2: 231-6.
    • (2007) ACS Chem Biol. , vol.2 , pp. 231-236
    • Segalat, L.1
  • 9
    • 79955749505 scopus 로고    scopus 로고
    • Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery
    • Pandey UB, Nichols CD. Human disease models in Drosophila melanogaster and the role of the fly in therapeutic drug discovery. Pharmacol Rev. 2011; 63: 411-36.
    • (2011) Pharmacol Rev. , vol.63 , pp. 411-436
    • Pandey, U.B.1    Nichols, C.D.2
  • 10
    • 7644239149 scopus 로고    scopus 로고
    • Drosophila, an emerging model for cardiac disease
    • Bier E, Bodmer R. Drosophila, an emerging model for cardiac disease. Gene. 2004; 342: 1-11.
    • (2004) Gene. , vol.342 , pp. 1-11
    • Bier, E.1    Bodmer, R.2
  • 11
    • 34250212943 scopus 로고    scopus 로고
    • Genetic control of heart function and aging in Drosophila
    • Ocorr K, Perrin L, Lim HY, et al. Genetic control of heart function and aging in Drosophila. Trends Cardiovasc Med. 2007; 17: 177-82.
    • (2007) Trends Cardiovasc Med. , vol.17 , pp. 177-182
    • Ocorr, K.1    Perrin, L.2    Lim, H.Y.3
  • 12
    • 0034837386 scopus 로고    scopus 로고
    • A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster
    • Reiter LT, Potocki L, Chien S, et al. A systematic analysis of human disease-associated gene sequences in Drosophila melanogaster. Genome Res. 2001; 11: 1114-25.
    • (2001) Genome Res. , vol.11 , pp. 1114-1125
    • Reiter, L.T.1    Potocki, L.2    Chien, S.3
  • 13
    • 0028959673 scopus 로고
    • Heart development in Drosophila and its relationship to vertebrate systems
    • Bodmer R. Heart development in Drosophila and its relationship to vertebrate systems. Trends Cardiovasc Med. 1995; 5: 21-7.
    • (1995) Trends Cardiovasc Med. , vol.5 , pp. 21-27
    • Bodmer, R.1
  • 15
    • 79955553504 scopus 로고    scopus 로고
    • A mighty small heart: the cardiac proteome of adult Drosophila melanogaster
    • Cammarato A, Ahrens CH, Alayari NN, et al. A mighty small heart: the cardiac proteome of adult Drosophila melanogaster. PLoS ONE. 2011; 6: e18497.
    • (2011) PLoS ONE. , vol.6
    • Cammarato, A.1    Ahrens, C.H.2    Alayari, N.N.3
  • 16
    • 0027282774 scopus 로고
    • The gene tinman is required for specification of the heart and visceral muscles in Drosophila
    • Bodmer R. The gene tinman is required for specification of the heart and visceral muscles in Drosophila. Development. 1993; 118: 719-29.
    • (1993) Development. , vol.118 , pp. 719-729
    • Bodmer, R.1
  • 17
    • 0029090829 scopus 로고
    • Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5
    • Lyons I, Parsons LM, Hartley L, et al. Myogenic and morphogenetic defects in the heart tubes of murine embryos lacking the homeo box gene Nkx2-5. Genes Dev. 1995; 9: 1654-66.
    • (1995) Genes Dev. , vol.9 , pp. 1654-1666
    • Lyons, I.1    Parsons, L.M.2    Hartley, L.3
  • 18
    • 0032479573 scopus 로고    scopus 로고
    • Congenital heart disease caused by mutations in the transcription factor NKX2-5
    • Schott JJ, Benson DW, Basson CT, et al. Congenital heart disease caused by mutations in the transcription factor NKX2-5. Science. 1998; 281: 108-11.
    • (1998) Science. , vol.281 , pp. 108-111
    • Schott, J.J.1    Benson, D.W.2    Basson, C.T.3
  • 19
    • 33749317433 scopus 로고    scopus 로고
    • Gene regulatory networks for the development and evolution of the chordate heart
    • Satou Y, Satoh N. Gene regulatory networks for the development and evolution of the chordate heart. Genes Dev. 2006; 20: 2634-8.
    • (2006) Genes Dev. , vol.20 , pp. 2634-2638
    • Satou, Y.1    Satoh, N.2
  • 20
    • 4644242353 scopus 로고    scopus 로고
    • Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells
    • Kim SK, Rulifson EJ. Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells. Nature. 2004; 431: 316-20.
    • (2004) Nature. , vol.431 , pp. 316-320
    • Kim, S.K.1    Rulifson, E.J.2
  • 21
    • 34548847172 scopus 로고    scopus 로고
    • Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila
    • Baker KD, Thummel CS. Diabetic larvae and obese flies-emerging studies of metabolism in Drosophila. Cell Metab. 2007; 6: 257-66.
    • (2007) Cell Metab. , vol.6 , pp. 257-266
    • Baker, K.D.1    Thummel, C.S.2
  • 22
    • 20044393471 scopus 로고    scopus 로고
    • Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands
    • Broughton SJ, Piper MD, Ikeya T, et al. Longer lifespan, altered metabolism, and stress resistance in Drosophila from ablation of cells making insulin-like ligands. Proc Natl Acad Sci USA. 2005; 102: 3105-10.
    • (2005) Proc Natl Acad Sci USA. , vol.102 , pp. 3105-3110
    • Broughton, S.J.1    Piper, M.D.2    Ikeya, T.3
  • 23
    • 0038522675 scopus 로고    scopus 로고
    • Mode of action of neuropeptides from the adipokinetic hormone family
    • Gade G, Auerswald L. Mode of action of neuropeptides from the adipokinetic hormone family. Gen Comp Endocrinol. 2003; 132: 10-20.
    • (2003) Gen Comp Endocrinol. , vol.132 , pp. 10-20
    • Gade, G.1    Auerswald, L.2
  • 24
    • 0028906170 scopus 로고
    • Identification and expression of the Drosophila adipokinetic hormone gene
    • Noyes BE, Katz FN, Schaffer MH. Identification and expression of the Drosophila adipokinetic hormone gene. Mol Cell Endocrinol. 1995; 109: 133-41.
    • (1995) Mol Cell Endocrinol. , vol.109 , pp. 133-141
    • Noyes, B.E.1    Katz, F.N.2    Schaffer, M.H.3
  • 25
    • 2942590660 scopus 로고    scopus 로고
    • Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster
    • Lee G, Park JH. Hemolymph sugar homeostasis and starvation-induced hyperactivity affected by genetic manipulations of the adipokinetic hormone-encoding gene in Drosophila melanogaster. Genetics. 2004; 167: 311-23.
    • (2004) Genetics. , vol.167 , pp. 311-323
    • Lee, G.1    Park, J.H.2
  • 26
    • 12344305171 scopus 로고    scopus 로고
    • AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila
    • Isabel G, Martin JR, Chidami S, et al. AKH-producing neuroendocrine cell ablation decreases trehalose and induces behavioral changes in Drosophila. Am J Physiol Regul Integr Comp Physiol. 2005; 288: R531-8.
    • (2005) Am J Physiol Regul Integr Comp Physiol. , vol.288
    • Isabel, G.1    Martin, J.R.2    Chidami, S.3
  • 27
    • 0141733277 scopus 로고    scopus 로고
    • A nutrient sensor mechanism controls Drosophila growth
    • Colombani J, Raisin S, Pantalacci S, et al.A nutrient sensor mechanism controls Drosophila growth. Cell. 2003; 114: 739-49.
    • (2003) Cell. , vol.114 , pp. 739-749
    • Colombani, J.1    Raisin, S.2    Pantalacci, S.3
  • 28
    • 78049425280 scopus 로고    scopus 로고
    • High fat diet-induced obesity and heart dysfunction is regulated by the TOR pathway in the Drosophila model
    • Birse R, Choi J, Reardon K, et al. High fat diet-induced obesity and heart dysfunction is regulated by the TOR pathway in the Drosophila model. Cell Metab. 2010; 12: 533-44.
    • (2010) Cell Metab. , vol.12 , pp. 533-544
    • Birse, R.1    Choi, J.2    Reardon, K.3
  • 29
    • 81455136679 scopus 로고    scopus 로고
    • A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila
    • Musselman LP, Fink JL, Narzinski K, et al.A high-sugar diet produces obesity and insulin resistance in wild-type Drosophila. Dis Model Mech. 2011; 4: 842-9.
    • (2011) Dis Model Mech. , vol.4 , pp. 842-849
    • Musselman, L.P.1    Fink, J.L.2    Narzinski, K.3
  • 30
    • 47249095129 scopus 로고    scopus 로고
    • The metabolic syndrome: a historical context
    • Crepaldi G, Maggi, S. The metabolic syndrome: a historical context. Diabetes Voice. 2006; 51: 8-10.
    • (2006) Diabetes Voice. , vol.51 , pp. 8-10
    • Crepaldi, G.1    Maggi, S.2
  • 31
    • 64949151149 scopus 로고    scopus 로고
    • A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts
    • Fink M, Callol-Massot C, Chu A, et al. A new method for detection and quantification of heartbeat parameters in Drosophila, zebrafish, and embryonic mouse hearts. BioTechniques. 2009; 46: 101-13.
    • (2009) BioTechniques. , vol.46 , pp. 101-113
    • Fink, M.1    Callol-Massot, C.2    Chu, A.3
  • 32
    • 77749264562 scopus 로고    scopus 로고
    • Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies
    • Lee JH, Budanov AV, Park EJ, et al. Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies. Science. 2010; 327: 1223-8.
    • (2010) Science. , vol.327 , pp. 1223-1228
    • Lee, J.H.1    Budanov, A.V.2    Park, E.J.3
  • 33
    • 78651490662 scopus 로고    scopus 로고
    • Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila
    • Lim HY, Wang W, Wessells RJ, et al. Phospholipid homeostasis regulates lipid metabolism and cardiac function through SREBP signaling in Drosophila. Genes Dev. 2011; 25: 189-200.
    • (2011) Genes Dev. , vol.25 , pp. 189-200
    • Lim, H.Y.1    Wang, W.2    Wessells, R.J.3
  • 34
    • 33744544947 scopus 로고    scopus 로고
    • Fatty acid auxotrophy in Drosophila larvae lacking SREBP
    • Kunte AS, Matthews KA, Rawson RB. Fatty acid auxotrophy in Drosophila larvae lacking SREBP. Cell Metab. 2006; 3: 439-48.
    • (2006) Cell Metab. , vol.3 , pp. 439-448
    • Kunte, A.S.1    Matthews, K.A.2    Rawson, R.B.3
  • 35
    • 79961165137 scopus 로고    scopus 로고
    • mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway
    • Peterson TR, Sengupta SS, Harris TE, et al. mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. Cell 2011; 146: 408-20.
    • (2011) Cell , vol.146 , pp. 408-420
    • Peterson, T.R.1    Sengupta, S.S.2    Harris, T.E.3
  • 36
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, Wu Z, Park CW, et al. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell. 1998; 92: 829-39.
    • (1998) Cell. , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3
  • 37
    • 0033977890 scopus 로고    scopus 로고
    • The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes
    • Vega RB, Huss JM, Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor alpha in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes. Mol Cell Biol. 2000; 20: 1868-76.
    • (2000) Mol Cell Biol. , vol.20 , pp. 1868-1876
    • Vega, R.B.1    Huss, J.M.2    Kelly, D.P.3
  • 38
    • 0037326196 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator
    • Puigserver P, Spiegelman BM. Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator. Endocr Rev. 2003; 24: 78-90.
    • (2003) Endocr Rev. , vol.24 , pp. 78-90
    • Puigserver, P.1    Spiegelman, B.M.2
  • 39
    • 8844276054 scopus 로고    scopus 로고
    • Regulation of muscle fiber type and running endurance by PPARdelta
    • Wang YX, Zhang CL, Yu RT, et al. Regulation of muscle fiber type and running endurance by PPARdelta. PLoS Biol. 2004; 2: e294.
    • (2004) PLoS Biol. , vol.2
    • Wang, Y.X.1    Zhang, C.L.2    Yu, R.T.3
  • 40
    • 5344252327 scopus 로고    scopus 로고
    • Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice
    • Lin J, Wu PH, Tarr PT, et al. Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alpha null mice. Cell. 2004; 119: 121-35.
    • (2004) Cell. , vol.119 , pp. 121-135
    • Lin, J.1    Wu, P.H.2    Tarr, P.T.3
  • 41
    • 79959635928 scopus 로고    scopus 로고
    • Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase
    • Lustig Y, Ruas JL, Estall JL, et al. Separation of the gluconeogenic and mitochondrial functions of PGC-1{alpha} through S6 kinase. Genes Dev. 2011; 25: 1232-44.
    • (2011) Genes Dev. , vol.25 , pp. 1232-1244
    • Lustig, Y.1    Ruas, J.L.2    Estall, J.L.3
  • 42
    • 0033803048 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis
    • Lehman JJ, Barger PM, Kovacs A, et al. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest. 2000; 106: 847-56.
    • (2000) J Clin Invest. , vol.106 , pp. 847-856
    • Lehman, J.J.1    Barger, P.M.2    Kovacs, A.3
  • 43
    • 80052812434 scopus 로고    scopus 로고
    • The PGC-1 cascade as a therapeutic target for heart failure
    • Schilling J, Kelly DP. The PGC-1 cascade as a therapeutic target for heart failure. J Mol Cell Cardiol. 2011; 51: 578-83.
    • (2011) J Mol Cell Cardiol. , vol.51 , pp. 578-583
    • Schilling, J.1    Kelly, D.P.2
  • 44
    • 47549114849 scopus 로고    scopus 로고
    • Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart
    • Lai L, Leone TC, Zechner C, et al. Transcriptional coactivators PGC-1alpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart. Genes Dev. 2008; 22: 1948-61.
    • (2008) Genes Dev. , vol.22 , pp. 1948-1961
    • Lai, L.1    Leone, T.C.2    Zechner, C.3
  • 45
    • 34248207609 scopus 로고    scopus 로고
    • High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO
    • Gershman B, Puig O, Hang L, et al. High-resolution dynamics of the transcriptional response to nutrition in Drosophila: a key role for dFOXO. Physiol Genomics. 2007; 29: 24-34.
    • (2007) Physiol Genomics. , vol.29 , pp. 24-34
    • Gershman, B.1    Puig, O.2    Hang, L.3
  • 46
    • 75649131899 scopus 로고    scopus 로고
    • The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling
    • Tiefenbock SK, Baltzer C, Egli NA, et al. The Drosophila PGC-1 homologue Spargel coordinates mitochondrial activity to insulin signalling. EMBO J. 2010; 29: 171-83.
    • (2010) EMBO J. , vol.29 , pp. 171-183
    • Tiefenbock, S.K.1    Baltzer, C.2    Egli, N.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.