Optimizing pharmacokinetic properties and attaining candidate selection

Topics in Medicinal Chemistry

Volumn 11, Issue , 2014, Pages 73-96

  Ward, Keith W ^a  

^a Reata Pharmaceuticals Inc   (United States)

Author keywords

Bioavailability; Clearance; Pharmacokinetic; Volume

Indexed keywords

EID: 84914179474     PISSN: 18622461     EISSN: 1862247X     Source Type: Book Series    
DOI: 10.1007/7355_2012_19     Document Type: Article

References (66)

1. Frank R, Hargreaves R (2003) Nat Rev Drug Discov 2:566
2. Ekins S, Waller CL, Swaan PW, Cruciani G, Wrighton SA, Wikel JH (2000) J Pharmacol Toxicol Methods 44:251
3. Lipinski CA, Lombardo F, Dominy BW, Feeny PJ (1997) Adv Drug Deliv Rev 23:3
4. Veber DF, Johnson SR, Cheng H-Y, Smith BR, Ward KW, Kopple KD (2002) J Med Chem 45:2615
5. Stouch TR, Kenyon JR, Johnson SR, Chen X-Q, Doweyko A, Li Y (2003) J Comput Aided Mol Des 17:83
6. Steward RB, Cooper JW (1994) Drugs Aging 4:449
7. Huang S-M (2004) Drug-drug interactions. In: Krishna R (ed) Applications of pharmacokinetic principles in drug development. Kluwer Academic/Plenum Publishers, New York, p 307
8. Cupp MJ, Tracy TS (1998) Am Fam Physician 57:107
9. Miller VP, Stresser DM, Blanchard AP, Turner S, Crespi CL (2000) Ann NY Acad Sci 919:26
10. Ward KW, Stelman GJ, Morgan JA, Zeigler KS, Azzarano LM, Kehler JR, McSurdy-Freed JE, Proksch JW, Smith BR (2004) Drug Metab Dispos 32:172
11. Ward KW, Griffiths R, Levy MA, Smith BR (2000) J Pharmacol Exp Ther 293:468
12. Lin JH (2006) Pharm Res 23:1089
13. Dickens M (2004) Curr Top Med Chem 4:1745
14. Woolf TF (ed) (1999) Handbook of drug metabolism. Marcel Dekker, New York
15. Mizuno N, Niwa T, Yotsumoto Y, Sugiyama Y (2003) Pharm Rev 55:425
16. Chandra P, Brouwer KLR (2004) Pharm Res 21:719
17. Dietrich CG, Geier A, Oude Elferink RPJ (2003) Gut 52:1788
18. Chan LMS, Lowes S, Hirst BH (2004) Eur J Pharm Sci 21:25
19. Dresser ML, Leabman MK, Giacomini KM (2001) J Pharm Sci 90:397
20. Kusuhara H, Sugiyama Y (2004) Adv Drug Deliv Rev 56:1741
21. Polli JW, Wring SA, Humphreys JE, Huang L, Morgan JB, Webster LO, Serabjit-Singh CS (2001) J Pharmacol Exp Ther 299:620
22. Ninomiya M, Ito K, Horie T (2005) Drug Metab Dispos 33:225
23. Godinot N, Iversen PW, Tabas L, Xia X, Williams DC, Dantzig AH, Perry WL 3rd (2003) Mol Cancer Ther 2:307
24. Akita H, Suzuki H, Sugiyama Y (2001) Pharm Res 18:1119
25. Oguro T, Kaneko E, Kaneko Y, Numazawa S, Imaoka S, Funae Y, Mikami T, Yoshia T (1996) J Pharmacol Exp Ther 277:1676
26. Schuetz EG, Umbenhauer DR, Yasuda K, Brimer C, Nguyen L, Relling MV, Schuetz JD, Schinkel AH (2000) Mol Pharmacol 57:188
27. Chiou WL, Chung SM, Wu TC, Ma C (2001) Int J Clin Pharmacol Ther 39:93
28. Lin JH, Yamazaki M (2003) Drug Metab Rev 35:417
29. Lin JH (2004) Drugs Today 40:5
30. Summerfield SG, Stevens AJ, Cutler L, del Carmen Osuna M, Hammond B, Tang SP, Hersey A, Spalding DJ, Jeffrey P (2006) J Pharmacol Exp Ther 316:1282
31. van Breeman RB, Li Y (2005) Expert Opin Drug Metab Toxicol 1:175
32. Zuegge J, Schneider G, Coassolo P, Lave T (2001) Clin Pharmacokinet 40:553
33. Gabrielsson J, Weiner D (1997) Pharmacokinetic and pharmacodynamic data analysis: concepts and applications. Apotekarsocieteten, Stockholm
34. Ward KW, Smith BR (2004) Drug Metab Dispos 32:612
35. Ward KW, Smith BR (2004) Drug Metab Dispos 32:603
36. Jolivette LJ, Ward KW (2005) J Pharm Sci 94:1467
37. Ward KW, Nagilla R, Jolivette LJ (2005) Xenobiotica 35:191
38. Frick LW, Adkison KK, Wells-Knecht KJ, Woollard P, Higton DM (1998) Pharm Sci Technol Today 1:12
39. Mei H, Korfmacher W, Morrison R (2006) AAPS J 8:E493
40. Hop CE, Wang Z, Chen Q, Kei G (1998) J Pharm Sci 87:901
41. Borchardt RT, Smith PL, Wilson G (eds) (1996) Models for assessing drug absorption and metabolism. Plenum Press, New York
42. Di L, Kerns EH, Hong Y, Kleintop TA, McConnell OJ, Huryn DM (2003) J Biomol Screen 8:453
43. Wilson ZE, Rostami-Hodjegan A, Burn JL, Tooley A, Boyle J, Ellis SW, Tucker GT (2003) Br J Clin Pharm 56:433
44. Shimada T, Yamazaki H, Mimura M, Inui Y, Guengerich FP (1994) J Pharmacol Exp Ther 270:414
45. Jones HM, Houston JB (2004) Drug Metab Dispos 32:973
46. Kalvass JC, Tess DA, Giragossian C, Linhares MC, Maurer TS (2001) Drug Metab Dispos 29:1332
47. Obach RS (1999) Drug Metab Dispos 27:1350
48. Yin H, Tran P, Greenberg GE, Fischer V (2001) Drug Metab Dispos 29:185
49. Uchaipichat V, MacKenzie PI, Guo X-H, Gardner-Stephen D, Galetin A, Houston JB, Miners JO (2004) Drug Metab Dispos 32:413
50. Nagilla R, Frank KA, Jolivette LJ, Ward KW (2006) J Pharmacol Toxicol Methods 53:106
51. Lappin G, Garner RC (2003) Nat Rev Drug Discov 2:233
52. Wilding I, Garner RC (2004) Good Clin Pract J 11:2
53. Sandhu P, Vogel JS, Rose MJ, Ubick EA, Brunner JE, Wallace MA, Adelsberger JK, Baker MP, Henderson PT, Pearson PG, Baillie TA (2004) Drug Metab Dispos 32:1254
54. Rowland M, Tozer TN (eds) (1995) Clinical pharmacokinetics. Lippincott Williams & Wilkins, Philadelphia
55. Craig WA, Ebert SC (1989) Infect Dis Clin North Am 3:407
56. Pajouhesh H, Lenz GR (2005) NeuroRx 2:541
57. Trainor GL (2007) Exp Opin Drug Discovery 2:51
58. Tillement J-P, Landenlaub E (eds) (1986) Protein binding and drug transport. FK Schattauer Verlag, Stuttgart
59. Annesley TM (2003) Clin Chem 49:1041
60. Wu S, Liu B (2005) BioDrugs 19:383
61. Li Y-W, Hill G, Wong H, Kelly N, Ward K, Pierdomenico M, Ren S, Gilligan P, Grossman S, Trainor G, Taub R, McElroy J, Zazcek R (2003) J Pharmacol Exp Ther 305:86
62. Uetrecht J (2003) Drug Discov Today 8:832
63. Dalvie DK, Kalgutkar AS, Khojasteh-Bakht SD, Obach RS, O’Donnell JP (2002) Chem Res Toxicol 15:269
64. Evans DC, Watt AP, Nicoll-Griffith DA, Baillie TA (2004) Chem Res Toxicol 17:3
65. Samuel K, Yin W, Stearns RA, Tang YS, Chaudhary AG, Jewell JP, Lanza T Jr, Lin SA, Hagmann WK, Evans DC, Kumar S (2003) J Mass Spectrom 38:211
66. Evans CA, Fries HE, Ward KW (2005) Chem Biol Interact 152:25