In vitro metabolic fate of a novel structural class: Evidence for the formation of a reactive intermediate on a benzothiophene moiety

Chemico-Biological Interactions

Volumn 152, Issue 1, 2005, Pages 25-36

  Evans, Christopher A ^a   Fries, Harvey E ^a   Ward, Keith W ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Arene oxide; Exact mass mass spectrometry; Hepatocytes; In vitro metabolism

Indexed keywords

BENZOTHIOPHENE DERIVATIVE; GLUTATHIONE; POLYCYCLIC AROMATIC HYDROCARBON DERIVATIVE;

ANIMAL CELL; CHEMICAL PROCEDURES; CONFERENCE PAPER; CONTROLLED STUDY; LIQUID CHROMATOGRAPHY; MALE; MASS SPECTROMETRY; METABOLISM; NONHUMAN; RAT; SUBSTITUTION REACTION; TANDEM MASS SPECTROMETRY;

ARENE;

EID: 17644374794     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cbi.2005.01.005     Document Type: Conference Paper

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