A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. II. Volume of distribution and mean residence time

Drug Metabolism and Disposition

Volumn 32, Issue 6, 2004, Pages 612-619

  Ward, Keith W ^a   Smith, Brian R ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

XENOBIOTIC AGENT;

ALLOMETRY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WATER; BODY WEIGHT; CONTROLLED STUDY; CORRELATION COEFFICIENT; DISTRIBUTION VOLUME; DOG; DRUG CLEARANCE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LIVER BLOOD FLOW; MEAN RESIDENCE TIME; MONKEY; NONHUMAN; NORMAL HUMAN; PREDICTION AND FORECASTING; PRIORITY JOURNAL; RAT; SPECIES DIFFERENCE;

ANIMALS; BIOMETRY; BLOOD VOLUME; DOGS; DRUG EVALUATION, PRECLINICAL; HUMANS; INJECTIONS, INTRAVENOUS; MACACA FASCICULARIS; MACACA MULATTA; PHARMACOKINETICS; RATS; SPECIES SPECIFICITY; XENOBIOTICS;

ANIMALIA; CANIS FAMILIARIS;

EID: 2442691625     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.6.612     Document Type: Article

References (9)

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4. Ings RMJ (1990) Interspecies scaling and comparisons in drug development and toxicokinetics. Xenobiotica 20:1201-1231.
5. Lombardo F, Obach RS, Shalaeva MY, and Gao F (2002) Prediction of volume of distribution values in humans for neutral and basic drugs using physiochemical measurements and plasma protein binding data. J Med Chem 45:2867-2876.
6. Mahmood I (1999) Allometric issues in drug development. J Pharm Sci 88:1101-1106.
7. Mahmood I and Balian JD (1996) Interspecies scaling: a comparative study for the prediction of clearance and volume using two or more than two species. Life Sci 59:579-585.
8. Obach RS, Baxter JG, Liston TE, Silber BM, Jones BC, MacIntyre F, Rance DJ, and Wastall P (1997) The prediction of human pharmacokinetic parameters from preclinical and in vitro metabolism data. J Pharmacol Exp Ther 283:46-58.
9. Ward KW and Smith BR (2004) A comprehensive quantitative and qualitative evaluation of extrapolation of intravenous pharmacokinetic parameters from rat, dog, and monkey to humans. I. Clearance. Drug Metab Dispos 32:603-611.