Optimization of a higher throughput microsomal stability screening assay for profiling drug discovery candidates

Journal of Biomolecular Screening

Volumn 8, Issue 4, 2003, Pages 453-462

  Di, Li ^a   Kerns, Edward H ^a   Hong, Yan ^a   Kleintop, Teresa A ^a   McConnell, Oliver J ^a   Huryn, Donna M ^a  

^a PFIZER INC   (United States)

Author keywords

Drug metabolism; High throughput screening; LCMSMS; Microsomal stability

Indexed keywords

BUSPIRONE; DESIPRAMINE; IMIPRAMINE; LOPERAMIDE; MIDAZOLAM; PROPRANOLOL; THIORIDAZINE; WARFARIN; DRUG; DYES, REAGENTS, INDICATORS, MARKERS AND BUFFERS;

ANIMAL TISSUE; ARTICLE; AUTOMATION; COMBINATORIAL CHEMISTRY; DRUG BIOAVAILABILITY; DRUG DETERMINATION; DRUG HALF LIFE; FIRST PASS EFFECT; HIGH THROUGHPUT SCREENING; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MICROSOME; MOUSE; NONHUMAN; PRIORITY JOURNAL; QUALITY CONTROL; RAT; REPRODUCIBILITY; ROBOTICS; ANIMAL; DRUG DESIGN; DRUG STABILITY; EVALUATION; LIVER MICROSOME; METABOLISM; METHODOLOGY;

ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG DESIGN; DRUG STABILITY; INDICATORS AND REAGENTS; MASS SPECTROMETRY; MICROSOMES, LIVER; PHARMACEUTICAL PREPARATIONS; QUALITY CONTROL; RATS; REPRODUCIBILITY OF RESULTS;

EID: 2142722247     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/1087057103255988     Document Type: Article

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