Methanol solvent may cause increased apparent metabolic instability in in vitro assays

Drug Metabolism and Disposition

Volumn 29, Issue 2, 2001, Pages 185-193

  Yin, Hequn ^a   Tran, Phi ^a   Greenberg, Gerald E ^a   Fischer, Volker ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [(5 CHLORO 2 PYRIDINYL)AMINO] 1,1 DIMETHYLETHYLAMINE; CYTOCHROME P450; DRUG; FORMALDEHYDE; GLUTATHIONE; HETEROCYCLIC COMPOUND; HYDROXYL GROUP; ISOPRENALINE; METARAMINOL; METHANOL; NICOTINAMIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL INTERACTION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG DETERMINATION; DRUG METABOLISM; DRUG STABILITY; DRUG STRUCTURE; ENZYME ACTIVITY; HUMAN; HUMAN CELL; LIVER MICROSOME; POLYMERIZATION; PRIORITY JOURNAL;

CYTOCHROME P-450 ENZYME SYSTEM; DRUG STABILITY; FORMALDEHYDE; HUMANS; ISOPROTERENOL; KINETICS; METARAMINOL; METHANOL; MICROSOMES, LIVER; PYRIDINES; SOLVENTS;

EID: 0035147085     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

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