Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure

Journal of Pharmaceutical Sciences

Volumn 94, Issue 7, 2005, Pages 1467-1483

  Jolivette, Larry J ^a   Ward, Keith W ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

Clearance; Computational ADME; Distribution; Mean residence time; Physicochemical properties; Preclinical pharmacokinetics

Indexed keywords

1 AMINOCYCLOPROPANECARBOXYLIC ACID; 6 (1 METHYL 1,2,3 TRIAZOL 4 YLMETHYLENE)PENEM 3 CARBOXYLIC ACID; ACICLOVIR; ACIVICIN; ACTISOMIDE; ALFENTANIL; AMIFLOXACIN; AMPHOTERICIN B; AZTREONAM; BETAMIPRON; BIAPENEM; CAPTOPRIL; CEFAZOLIN; CEFCLIDIN; CEFEPIME; CEFMETAZOLE; CEFODIZIME; CEFOPERAZONE; CEFOTETAN; CEFOZOPRAN; CEFPIRAMIDE; CEFTIZOXIME; CEFTRIAXONE; CITALOPRAM; CLONAZEPAM; COUMARIN; DRUG; LEVODOPA; PHENAZONE; UNINDEXED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DATA ANALYSIS; DOG; DRUG CLEARANCE; DRUG DISTRIBUTION; HISTOGRAM; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; HYDROGEN BOND; MEAN RESIDENCE TIME; MOLECULAR WEIGHT; MONKEY; NONHUMAN; NORMAL HUMAN; PARTITION COEFFICIENT; RAT; RELIABILITY; SURFACE PROPERTY;

EID: 23844500635     PISSN: 00223549     EISSN: None     Source Type: Journal    
DOI: 10.1002/jps.20373     Document Type: Article

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