Evaluation of the use of accelerated infusions for the determination of pharmacokinetic linearity

Journal of Pharmacology and Experimental Therapeutics

Volumn 293, Issue 2, 2000, Pages 468-479

  Ward, Keith W ^a   Griffiths, Robin ^b   Levy, Mark A ^a   Smith, Brian R ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b The Frythe   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ARTICLE; CONCENTRATION RESPONSE; DRUG CLEARANCE; DRUG DETERMINATION; DRUG DISTRIBUTION; DRUG INFUSION; DRUG METABOLISM; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIMULATION;

ALGORITHMS; ANIMALS; DATA INTERPRETATION, STATISTICAL; INFUSIONS, INTRAVENOUS; MALE; MODELS, BIOLOGICAL; NONLINEAR DYNAMICS; PHARMACOKINETICS; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0034014670     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (7)

1. Gabrielsson J and Weiner D (1997) Pharmacokinetic/Pharmacodynamic Data Analysis. Apotekarsocieteten, Stockholm.
2. Gibaldi M and Perrier D (1982) Pharmacokinetics. Academic Press, New York.
3. Kuhlmann J (1997) Drug research: From the idea to the product. Int J Clin Pharmacol Ther 35:541-552.
4. Li J, Dobson GL, Marietta MP, Rhodes GR and Hidalgo IJ (1997) In vivo determination of drug kinetic linearity and individual organ elimination by the accelerated infusion technique. J Pharmacol Toxicol Methods 37:47-53.
5. Ludden TM (1991) Nonlinear pharmacokinetics: Clinical implications. Clin Pharmacokinet 20:429-446.
6. O'Flaherty EJ (1981) Toxicants and Drugs: Kinetics and Dynamics. John Wiley & Sons, New York.
7. Ohlstein EH, Nambi P, Lago A, Hay DWP, Beck G, Fong K-L, Eddy EP, Smith P, Ellens H and Elliott JD (1996) Nonpeptide endothelin receptor antagonists. VI: Pharmacological characterization of SB 217242, a potent and highly bioavailable endothelin receptor antagonist. J Pharmacol Exp Ther 276:609-615.