Effects of rolipram and roflumilast, phosphodiesterase-4 inhibitors, on hypertension-induced defects in memory function in rats

European Journal of Pharmacology

Volumn 746, Issue , 2015, Pages 138-147

  Jabaris, Sobhana George Sugin Lal ^a   Sumathy, Haridass ^a   Kumar, Ramadass Satiesh ^b   Narayanan, Shridhar ^c   Thanikachalam, Sadagopan ^a   Babu, Chidambaram Saravana ^a  

^a SRI RAMACHANDRA UNIVERSITY   (India)

^b CENTRAL LEATHER RESEARCH INSTITUTE   (India)

^c ASTRAZENECA   (United Kingdom)

Author keywords

Cognition; Hypertension; N oxide; Roflumilast; Rolipram

Indexed keywords

CLONIDINE; MESSENGER RNA; PHOSPHODIESTERASE IV; ROFLUMILAST; ROLIPRAM; AMINOPYRIDINE DERIVATIVE; BENZAMIDE DERIVATIVE; CORTICOSTERONE; CYCLOPROPANE DERIVATIVE; PHOSPHODIESTERASE IV INHIBITOR; ROFLUMILAST N-OXIDE;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG ACCUMULATION; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG EFFECT; ELEVATED PLUS MAZE TEST; GENE EXPRESSION; HIPPOCAMPUS; HYPERTENSION; LEARNING DISORDER; MALE; MEMORY DISORDER; NONHUMAN; NOVEL OBJECT RECOGNITION TEST; RAT; SYSTOLIC BLOOD PRESSURE; ANIMAL; BLOOD; BLOOD PRESSURE; BRAIN; COGNITION; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; MAZE TEST; MEMORY; METABOLISM; PATHOPHYSIOLOGY; PHYSIOLOGY; RECOGNITION; WISTAR RAT;

AMINOPYRIDINES; ANIMALS; BENZAMIDES; BLOOD PRESSURE; BRAIN; COGNITION; CORTICOSTERONE; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; CYCLOPROPANES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HYPERTENSION; MALE; MAZE LEARNING; MEMORY; PHOSPHODIESTERASE 4 INHIBITORS; RATS; RATS, WISTAR; RECOGNITION (PSYCHOLOGY); RNA, MESSENGER; ROLIPRAM;

EID: 84914170739     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2014.10.039     Document Type: Article

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