PDE4 inhibitors induce emesis in ferrets via a noradrenergic pathway

Neuropharmacology

Volumn 40, Issue 2, 2001, Pages 262-269

  Robichaud, A ^a   Savoie, C ^a   Stamatiou, P B ^a   Tattersall, F D ^b   Chan, C C ^a  

^a MERCK FROSST CENTRE FOR THERAPEUTIC RESEARCH   (Canada)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

Author keywords

Alpha2 adrenoceptor; Duration of anaesthesia; Emesis; PDE4 inhibitors; Righting reflex

Indexed keywords

1 [4 [1 (3 CYCLOPENTYLOXY 4 METHOXYPHENYL) 2 (4 PYRIDYL)ETHYL]PHENYL] 3 ETHYLUREA; 1,3,4,5',6,6',7,12B OCTAHYDRO 1',3' DIMETHYL 2H SPIRO[BENZO[B]FURO[2,3 A]QUINOLIZINE 2,4' PYRIMIDINE] 2' ONE; 8 (3 NITROPHENYL) 6 (4 PYRIDYLMETHYL0QUINOLINE; ALPHA 2 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CLONIDINE; CT 2450; KETAMINE; N [2 (1,3,4,6,7,12B HEXAHYDRO 2' OXOSPIRO[2H BENZOFURO[2,3 A]QUINOLIZINE 2,4' IMIDAZOLIDIN] 3' YL)ETHYL]METHANESULFONAMIDE; PHOSPHODIESTERASE IV INHIBITOR; PRAZOSIN; ROLIPRAM; UNCLASSIFIED DRUG; XYLAZINE; YOBINE; YOHIMBINE;

ANESTHESIA; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MIXTURE; FERRET; HYPERVENTILATION; MALE; NONHUMAN; NORADRENERGIC SYSTEM; PRIORITY JOURNAL; RAT; SALIVATION; VOMITING;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ADRENERGIC ALPHA-AGONISTS; ADRENERGIC ALPHA-ANTAGONISTS; ANESTHESIA; ANIMALS; FERRETS; MALE; PHOSPHODIESTERASE INHIBITORS; PYRIDINES; QUINOLINES; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, ADRENERGIC, ALPHA-2; ROLIPRAM; VOMITING;

EID: 0035216330     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(00)00142-8     Document Type: Article

References (28)

1. The physiology of emesis induced by anti-cancer therapy
2. Inhibition of adenylate cyclase in the locus coeruleus mediates the hypnotic response to an alpha2 agonist in the rat
3. 2 adrenoceptor antagonist: L-659,066
4. Pharmacology of injectable anesthetics
5. The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects
6. Emetic, central nervous system and pulmonary activities of rolipram in the dog
7. 2-adrenoceptors in the emetic action of xylazine in cats
8. Alpha adrenoceptor subtypes involved in the emetic action in dogs
9. Central α-adrenoceptor subtypes involved in the emetic pathway in cats
10. Clinical effects of neurotropic selective cAMP phosphodiesterase inhibitor rolipram in depressed patients: global evaluation of the preliminary reports
11. Clonidine hydrochloride: review of pharmacological and clinical aspects
12. Pharmacokinetically governed design of animal toxicity studies of a new antidepressant drug
13. Clonidine-induced emesis: a multitransmitter pathway concept
14. Phosphodiesterase 4 inhibitors for the treatment of asthma
15. 2-adrenoceptors
16. Oral clonidine premedication for elderly patients undergoing intraocular surgery
17. Presynaptic regulation of the release of catecholamines
18. Oral clonidine premedication reduces vomiting in children after stabismus surgery
19. The safety and tolerability of Ariflo(TM) (SB207,499), a novel and selective phosphodiesterase 4 inhibitor, in healthy male volunteers
20. Inhibitors of cyclic nucleotide phosphodiesterase isoenzymes - their potential utility in the therapy of asthma
21. SB207,499 (Ariflo(TM)), a second generation, selective oral phosphodiesterase type 4 inhibitor, attenuates exercise induced bronchoconstriction in patients with asthma
22. Pharmacological profile of a new potent and specific α2-adrenceptor antagonist, L-657,743
23. Emesis induced by inhibitors of type IV cyclic nucleotide phosphodiesterase (PDE IV) in the ferret
24. SB-207499
25. Effects of yohimbine on bradycardia and duration of recumbency in ketamine/xylazine anesthetized ferrets
26. Results of a phase II study of antidepressant effect of rolipram