Phosphodiesterase type 4 isozymes expression in human brain examined by in situ hybridization histochemistry and [3H]rolipram binding autoradiography: Comparison with monkey and rat brain

Journal of Chemical Neuroanatomy

Volumn 20, Issue 3-4, 2000, Pages 349-374

  Perez Torres S ^a   Miro X ^b   Palacios, J M ^c   Cortes R ^a   Puigdomenech P ^b   Mengod, G ^a  

^a INST D INVESTIGACIONS B   (Spain)

^b INSTITUT DE BIOLOGIA MOLECULAR DE BARCELONA   (Spain)

^c Almirall Prodesfarma SA ^*  (Spain)

Author keywords

cAMP specific phosphodiesterase; mRNA localization; PDE4 inhibitor; Radioligand autoradiography

Indexed keywords

CYCLIC AMP; ISOENZYME; PHOSPHODIESTERASE IV; ROLIPRAM;

ADULT; AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; CELL LEVEL; COMPARATIVE STUDY; CONTROLLED STUDY; CORRELATION FUNCTION; ENZYME LOCALIZATION; FEMALE; HISTOCHEMISTRY; HUMAN; HUMAN TISSUE; IN SITU HYBRIDIZATION; MALE; MONKEY; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SPECIES DIFFERENCE; TISSUE DISTRIBUTION;

3',5'-CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; AGED; ANIMALS; AUTORADIOGRAPHY; BRAIN; FEMALE; GENE EXPRESSION; HUMANS; IN SITU HYBRIDIZATION; ISOENZYMES; MACACA FASCICULARIS; MALE; MIDDLE AGED; PHOSPHODIESTERASE INHIBITORS; RADIOLIGAND ASSAY; RATS; RATS, WISTAR; RNA, MESSENGER; ROLIPRAM; SPINAL CORD; TRITIUM;

EID: 0034468228     PISSN: 08910618     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0891-0618(00)00097-1     Document Type: Article

References (64)

1. Optimal conditions for hybridization with oligonucleotides: A study with myc-oncogene DNA probes
2. Mapping of second messenger and rolipram receptors in mammalian brain
3. Age-related defects in spatial memory are correlated with defects in the late phase of hippocampal long-term potentiation in vitro and are attenuated drugs that enhance the cAMP signaling
4. Rolipram, a type IV-specific phosphodiesterase inhibitor, facilitates the establishment of long-lasting long-term potentiation and improves memory
5. Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
6. Rolipram versus imipramine in inpatients with major, 'minor' or atypical depressive disorder: A double-blind double-dummy study aimed at testing a novel therapeutic approach
7. Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases
8. 3H]cAMP binding to cytosolic and particulate protein kinase A in post-mortem brain staged for Alzheimer's disease neurofibrillary changes and amyloid deposits
9. Physiology and pharmacology of vomiting
10. Lipopolysaccharide induces expression of tumour necrosis factor alpha in rat brain: Inhibition by methylprednisolone and by rolipram
11. Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila
12. Excitation of area postrema neurons by transmitters, peptides, and cyclic nucleotides
13. Cyclic AMP Phosphodiesterases are localized in regions of the mouse brain associated with reinforcement, movement and affect
14. Physiology and biochemistry of Drosophila learning mutants
15. Cloning and characterisation of mammalian homologs of the Drosophila dunce+gene
16. Anatomy of the normal human thalamus
17. Dunce, a mutant of Drosophila deficient in learning
18. Expression and regulation of human and rat phosphodiesterase type IV isogenes
19. Brain distribution of four rat homologues of the Drosophila Dunce cAMP phosphodiesterase
20. Molecular cloning and functional expression in yeast of a human cAMP-specific phosphodiesterase subtype (PDE IV-C)
21. Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A
22. Regional tritium quenching in quantitative autoradiography of the central nervous system
23. Absence of muscarinic cholinergic airway responses in mice deficient in the cyclic nucleotide phosphodiesterase PDE4D
24. Emetic, central nervous system, and pulmonary activities of rolipram in the dog
25. Rolipram in major depressive disorder: Results of a double-blind comparative study with imipramine
26. Clinical effects of the neurotropic selective cAMP phosphodiesterase inhibitor rolipram in depressed patients: Global evaluation of the preliminary reports
27. The multienzyme PDE4 cyclic adenosine monophosphate-specific phosphodiesterase family: Intracellular targeting, regulation, and selective inhibition by compounds exerting anti-inflammatory and anti-depressant actions
28. Differential distribution of mRNA encoding cAMP-specific phosphodiesterase isoforms in the rat brain
29. Impaired growth and fertility of cAMP-specific phosphodiesterase PDE4D-deficient mice
30. Molecular biology of learning: Modulation of transmitter release
31. A 'direct coloring' thiocholine method for cholinesterases
32. Rolipram, a cyclic AMP-selective phosphodiesterase inhibitor, reduces neuronal damage following cerebral ischemia in the gerbil
33. Tyrosine hydroxylase
34. 3H]rolipram
35. Signal transduction and gene regulation: The nuclear response to cAMP
36. The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
37. Anti-inflammatory drugs and Alzheimer's disease
38. Granule cells of the olfactory tubercle and the question of the Islands of Calleja
39. Cell configurations in the olfactory tubercle of the rat
40. Identification of cyclic AMP as the response regulator for neurosecretory potentiation: A memory model system
41. Multiple splice variants of phosphodiesterase PDE4C cloned from human lung and testis
42. Human phosphodiesterase 4A: Characterization of full-length and truncated enzymes in COS cells
43. Brain cAMP response to phosphodiesterase inhibitors in rats killed by microwave irradiation or decapitation
44. Stereospecific binding of the antidepressant rolipram to brain protein structures
45. Effects of rolipram on the elevated plus-maze test in rats: A preliminary study
46. Preliminary evidence,of an involvement of the cholinergic system in the sedative affects of rolipram in rats
47. Regulation of cAMP and cGMP signalling: New phosphodiesterases and new functions
48. The antidepressant rolipram suppresses cytokine production and prevents autoimmune encephalomyelitis
49. A semi-quantitative atlas of 5-hydroxytryptamine-1 receptors in the primate
50. A stereotaxic atlas of the brain of the cynomolgus monkey (Macaca fascicularis)
51. Chronic antidepressant administration increases the expression of cAMP-specific phosphodiesterase 4A and 4B isoforms
52. Multiple cyclic nucleotide phosphodiesterase activities in rat brain
53. Distribution of AMPA receptor subunit mRNAs in the human basal ganglia: An in situ hybridization study
54. Phosphodiesterases: The journey towards therapeutics
55. Potential anti-depressant activity of rolipram and other selective cyclic adenosine 3′, 5′-monophosphate phosphodiesterase inhibitors
56. Rolipram, a novel anti-depressant drug, reverses the hypothermia and hypokinesia of monoamine-depleted mice by an action beyond postsynaptic monoamine receptors
57. Rolipram, a phosphodiesterase-4-selective inhibitor, promotes the survival of cultured rat dopaminergic neurons
58. Results of a phase II study of the anti-depressant effect of rolipram
59. Altered synaptic plasticity in drosophila memory mutants with a defective cyclic AMP cascade