Hypertension induces brain β-amyloid accumulation, cognitive impairment, and memory deterioration through activation of receptor for advanced glycation end products in brain vasculature

Hypertension

Volumn 60, Issue 1, 2012, Pages 188-197

  Carnevale, Daniela ^a,b   Mascio, Giada ^a   D'Andrea, Ivana ^a   Fardella, Valentina ^a   Bell, Robert D ^c   Branchi, Igor ^d   Pallante, Fabio ^a   Zlokovic, Berislav ^e   Yan, Shirley Shidu ^e,f   Lembo, Giuseppe ^a,b  

^a IRCCS NEUROMED   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^d ISTITUTO SUPERIORE DI SANITÀ   (Italy)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f UNIVERSITY OF KANSAS   (United States)

Author keywords

Alzheimer disease; Basic science; Cognitive impairment; Hypertension; Receptor for advanced glycation end products

Indexed keywords

ADVANCED GLYCATION END PRODUCT RECEPTOR; AMYLOID BETA PROTEIN; ADVANCED GLYCATION END PRODUCT; ADVANCED GLYCOSYLATION END PRODUCT RECEPTOR; ADVANCED GLYCOSYLATION END-PRODUCT RECEPTOR; AMINOGUANIDINE; ENZYME INHIBITOR; GUANIDINE DERIVATIVE; IMMUNOGLOBULIN RECEPTOR; TIRON;

ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; BLOOD BRAIN BARRIER DYSFUNCTION; BRAIN DISEASE; COGNITIVE DEFECT; CONTROLLED STUDY; HIPPOCAMPUS; HYPERTENSION; MALE; MEMORY DISORDER; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; UPREGULATION; ANIMAL; AORTA COARCTATION; BLOOD VESSEL; BRAIN; C57BL MOUSE; DRUG EFFECT; GENE EXPRESSION; GENETICS; MAZE TEST; METABOLISM; MOUSE MUTANT; PATHOPHYSIOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULARIZATION; WESTERN BLOTTING;

1,2-DIHYDROXYBENZENE-3,5-DISULFONIC ACID DISODIUM SALT; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; AORTIC COARCTATION; BLOOD VESSELS; BLOTTING, WESTERN; BRAIN; COGNITION DISORDERS; ENZYME INHIBITORS; GENE EXPRESSION; GLYCOSYLATION END PRODUCTS, ADVANCED; GUANIDINES; HYPERTENSION; MAZE LEARNING; MEMORY DISORDERS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, IMMUNOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84865822723     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.112.195511     Document Type: Article

References (28)

1. Quaegebeur A, Lange C, Carmeliet P. The neurovascular link in health and disease: molecular mechanisms and therapeutic implications. Neuron. 2011;71:406-424.
2. Fotuhi M, Hachinski VP, Whitehouse J. Changing perspectives regarding late-life dementia. Nat Rev Neurol. 2009;5:649-658.
3. Iadecola C, Park L, Capone C. Threats to the mind: aging, amyloid, and hypertension. Stroke. 2009;40(3 suppl):S40-S44.
4. Iadecola C, Davisson RL. Hypertension and cerebrovascular dysfunction. Cell Metab. 2008;7:476-484.
5. Skoog D, Gustafson D. Update on hypertension and Alzheimer's disease. Neurol Res. 2006;28:605-611.
6. Zlokovic BV. New therapeutic targets in the neurovascular pathway in Alzheimer's disease. Neurotherapeutics. 2008;5:409-414.
7. Lustbader JW, Cirilli M, Lin C, Xu HW, Takuma K, Wang N, Caspersen C, Chen X, Pollak S, Chaney M, Trinchese F, Liu S, Gunn-Moore F, Lue LF, Walker DG, Kuppusamy P, Zewier ZL, Arancio O, Stern D, Yan SS, Wu H. ABAD directly links Aβ to mitochondrial toxicity in Alzheimer's disease. Science. 2004;304:448-452.
8. Zlokovic BV. The blood-brain barrier in health and chronic neurodegenerative disorders. Neuron. 2008;57:178-201.
9. Deane R, Du Yan S, Submamaryan RK, La Rue B, Jovanovic S, Hogg E, Welch D, Manness L, Lin C, Yu J, Zhu H, Ghiso J, Frangione B, Stern A, Schmidt AM, Armstrong DL, Arnold B, Liliensiek B, Nawroth P, Hofman F, Kindy M, Stern D, Zlokovic B. RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain. Nat Med. 2003;9:907-913.
10. Zlokovic BV, Deane R, Sagare AP, Bell RD, Winkler EA. Low-density lipoprotein receptor-related protein-1: a serial clearance homeostatic mechanism controlling Alzheimer's amyloid β-peptide elimination from the brain. J Neurochem. 2010;115:1077-1089.
11. Carnevale D, Mascio G, Ajmone-Cat MA, D'Andrea I, Cifelli G, Madonna M, Cocozza G, Frati A, Carullo P, Carnevale L, Alleva E, Branchi I, Lembo G, Minghetti L. Role of neuroinflammation in hypertension-induced brain amyloid pathology. Neurobiol Aging. 2012;205:e19-e29.
12. Gentile MT, Poulet R, Di Pardo A, Cifelli G, Maffei A, Vecchione C, Passarelli F, Landolfi A, Carullo P, Lembo G. β-Amyloid deposition in brain is enhanced in mouse models of arterial hypertension. Neurobiol Aging. 2009;30:222-228.
13. Selkoe DJ. Alzheimer's disease is a synaptic failure. Science. 2002;298:789-791.
14. Querfurth HW, La Ferla FM. Alzheimer's disease. N Engl J Med. 2010;362:329-344.
15. Deane R, Singh I, Sagare AP, Bell RD, Ross NT, La Rue B, Love R, Perry S, Paquette N, Deane RJ, Meenakshisundaram T, Zarcone T, Fritz G, Friedman AE, Miller BL, and Zlokovic BV. A multimodal RAGE-specific inhibitor reduces amyloid β-mediated brain disorder in a mouse model of Alzheimer disease. J Clin Invest. 2012;122:1377-1392.
16. Park L, Wang G, Zhou P, Zhou J, Pitstick R, Previti ML, Younkin L, Younkin SG, Van Nostrand WE, Cho S, Anrather J, Carlson GA, Iadecola C. Scavenger receptor CD36 is essential for the cerebrovascular oxidative stress and neurovascular dysfunction induced by amyloid-β. Proc Natl Acad Sci USA. 2011;108:5063-5068.
17. Donahue JE, Flaherty SL, Johanson CE, Duncan JA III, Silverberg GD, Miller MC, Tavares R, Yang W, Wu Q, Sabo E, Hovanesian V, Stopa EG. RAGE, LRP-1, and amyloid-β protein in Alzheimer's disease. Acta Neuropathol. 2006;112:405-415.
18. Fang F, Lue LF, Yan S, Xu H, Luddy JS, Chen D, Walker DG, Stern DM, Schmidt AM, Chen JX, Yan SS. RAGE-dependent signaling in microglia contributes to neuroinflammation, Aβ accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease. FASEB J. 2010;24:1043-1055.
19. Takuma K, Fang F, Zhang W, Yan S, Fukuzaki E, Du H, Sosunov A, McKhann G, Funatsu Y, Nakamichi N, Nagai T, Mizoguchi H, Ibi D, Hori O, Ogawa S, Stern DM, Yamada K, Yan SS. RAGE-mediated signaling contributes to intraneuronal transport of amyloid-β and neuronal dysfunction. Proc Natl Acad Sci USA. 2009;106:20021-20026.
20. Yan SF, Ramasamy R, Schmidt AM. The RAGE axis: a fundamental mechanism signaling danger to the vulnerable vasculature. Circ Res. 2010;106:842-853.
21. Li XH, Lv BL, Xie JZ, Liu J, Zhou XW, Wang JZ. AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation. Neurobiol Aging. March 31, 2011. DOI: 10.1016/j.neurobiolaging.2011.02.003. http://www.neurobiologyofaging.org/article/S0197-4580(11)00016-9/fulltext Accessed May 11, 2012.
22. Yamagishi S, Matsui T, Nakamura K, Inoue H, Takeuchi M, Ueda S, Fukami K, Okuda S, Imaizumi T. Olmesartan blocks advanced glycation end products (AGEs)-induced angiogenesis in vitro by suppressing receptor for AGEs (RAGE) expression. Microvasc Res. 2008;75:130-134.
23. Ihara Y, Egashira K, Nakano K, Ohtani K, Kubo M, Koga J, Iwai M, Horiuchi M, Gang Z, Yamagishi S, Sunagawa K. Upregulation of the ligand-RAGE pathway via the angiotensin II type I receptor is essential in the pathogenesis of diabetic atherosclerosis. J Mol Cell Cardiol. 2007;43:455-464.
24. McNulty M, Mahmud A, Feely J. Advanced glycation end-products and arterial stiffness in hypertension. Am J Hypertens. 2007;20:242-247.
25. Zieman SJ. Advanced glycation endproduct crosslink breaker (alagebrium) improves endothelial function in patients with isolated systolic hypertension. J Hypertens. 2007;25:577-583.
26. Liu H, Xing A, Wang X, Liu G, Li L. Regulation of β-amyloid level in the brain of rats with cerebrovascular hypoperfusion. Neurobiol Aging. 2012;826:e31-e42.
27. Papaharalambus CA, Griendling KK. Basic mechanisms of oxidative stress and reactive oxygen species in cardiovascular injury. Trends Cardiovasc Med. 2007;17:48-54.
28. Vecchione C, Carnevale D, Di Pardo A, Gentile MT, Damato A, Cocozza G, Antenucci G, Mascio G, Bettarini U, Landolfi A, Iorio L, Maffei A, Lembo G. Pressure-induced vascular oxidative stress is mediated through activation of integrin-linked kinase 1/βPIX/Rac-1 pathway. Hypertension. 2009;54:1028-1034.