The relationship between blood pressure and dementia: A review

Biomedicine and Pharmacotherapy

Volumn 51, Issue 9, 1997, Pages 367-375

  Skoog, I ^a  

^a SAHLGRENSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

Alzheimer's disease; Blood pressure; Dementia; Hypertension

Indexed keywords

ANTIHYPERTENSIVE AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; OXYGEN RADICAL;

ADULT; AGED; ALZHEIMER DISEASE; BLOOD PRESSURE; COGNITION; DEMENTIA; HUMAN; HYPERTENSION; PRIORITY JOURNAL; REVIEW;

EID: 0030667773     PISSN: 07533322     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0753-3322(97)89428-0     Document Type: Review

References (139)

1. 1 Adams JH, Brierley JB, Connor RCR, Treip CS. The effects of systemic hypotension upon the human brain. Clinical and neuropathological observations in 11 cases. Brain 1966;89:235-67
2. 2 Aharon-Peretz J, Cummings JL, Hill MA. Vascular dementia and dementia of the Alzheimer type. Cognition, ventricular size, and leuko-araiosis. Arch Neurol 1988;45:719-21
3. 3 Almkvist O, Wahlund LO, Andersson-Lundman G, Basun H, Bäckman L. White-matter hyperintensity and neuropsychological functions in dementia and healthy aging. Arch Neurol 1992;49:626-32
4. 4 Araga S, Kagimoto H, Funamoto K, Takahashi K. Reduced natural killer cell activity in patients with dementia of the Alzheimer type. Acta Neurol Scand 1991;84:259-63
5. 5 Aronson MK, Ooi WL, Morgenstern H, Hafner A, Masur D, Crystal H, Frishman WH, Fisher D, Katzman R. Women, myocardial infarction, and dementia in the very old. Neurology 1990;40:1102-6
6. 6 Babikian V, Ropper AH. Binswanger's disease: a review. Stroke 1987;18:2-12
7. 7 Baumbach GL, Heistad DD. Cerebrovascular disease in experimental models of hypertension. In: Swales JD, ed. Textbook of Hypertension. Oxford: Blackwell Scientific Publications, 1994
8. 8 Berg S. Psychological functioning in 70-and 75-year-old people. Acta Psychiatr Scand 1980;62(suppl 288):1-47
9. 9 Blennow K, Wallin A, Uhlemann C, Gottfries C. White-matter lesions on CT in Alzheimer patients: relation to clinical symptomatology and vascular factors. Acta Neurol Scand 1991;83:187-93
10. 10 Boller F, Vrtunski B, Mack JL. Kim Y. Neuropsychological correlates of hypertension. Arch Neurol 1977;34:701-5
11. 11 Boone KB, Miller BL, Lesser BL, Mehringer CM, Hill-Gutierrez E, Goldberg MA, Berman NG. Neuropsychological correlates of white-matter lesions in healthy elderly subjects. A threshold effect. Arch Neurol 1992;49:549-54
12. 12 Breteler MMB, Grobbee DE, Hofman A. Blood pressure, hypertension, orthostatic hypotension, and cognitive function in the elderly. The Rotterdam Study. In: Breteler MMB, ed. Cognitive decline in the elderly. Epidemiologic studies on cognitive function and dementia. Thesis, Erasmus University, Rotterdam, The Netherlands, 1993
13. 13 Breteler MMB, Claus JJ, Grobbee DE, Hofman A. Cardiovascular disease and distribution of cognitive function in elderly people: the Rotterdam study. Br Med J 1994;308:1604-8
14. 14 Breteler MMB, van Amerongen NM, van Swieten JC, Claus JJ, Grobbee DE, van Gijn J, Hofman A, van Harskamp F. Cognitive correlates of ventricular enlargement and cerebral white matter lesions on Magnetic Resonance Imaging. The Rotterdam study. Stroke 1994;25:1109-15
15. 15 Brun A, Englund E. A white matter disorder in dementia of the Alzheimer type: a pathoanatomical study. Ann Neurol 1986;19:253-62
16. 16 Burke WJ, Coronado PG, Schmitt CA, Gillespie KM, Chung HD. Blood pressure regulation in Alzheimer's disease. J Auton Nerv Syst 1994;48:65-71
17. 17 Calabrese JR, Kling MA, Gold PW. Alterations in immunocompetence during stress, bereavement, and depression: focus on neuroendocrine regulation. Am J Psychiatry 1987;144:1123-34
18. 18 Chalmer J, Arnolda L, Llewellyn-Smith I, Minson J, Pilowsky P. Central nervous control of blood pressure. In: Swales JD, ed. Textbook of Hypertension. Oxford: Blackwell Scientific Publications, 1994
19. 19 Corder EH, Saunders AM, Strittmatter WJ, Schmechel DE, Gaskell PC, Small GW, Roses AD, Haines JL, Pericak-Vance MA. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families. Science 1993;261:921-3
20. 20 Davignon J, Gregg RE, Sing CF. Apolipoprotein E polymorphism and atherosclerosis. Arteriosclerosis 1988;8:1-21
21. 21 De la Monte SM. Quantitation of cerebral atrophy in pre-clinical and end-stage Alzheimer's disease. Ann Neurol 1989;25:450-9
22. 22 De Leon MJ, George AE, Kluger A, Franssen E, Ferris SH, Wolf AP. PET-deoxyglucose, CT, and neuropathology of age-related white matter pathology in normals and Alzheimer's patients. Psychiatry Res 1989;29:359-60
23. 23 Del Ser T, Bermejo F, Portera A, Arredondo J, Bouras C, Constantinidis J. Vascular dementia. A clinicopathological study. J Neurol Sci 1990;96:1-17
24. 24 Derix MM, Hijdra A, Verbeeten BW Jr. Mental changes in subcortical arteriosclerotic encephalopathy. Clin Neurol Neurosurg 1987;89:71-8
25. 25 Dewar D, McCulloch J. Abnormalities in non-cholinergic neurotransmitter systems in Alzheimer's disease. In: Burns A, Levy R. eds. Dementia. London: Chapman and Hall, 1994
26. 26 Diaz FJ, Merskey H, Hachinski VC, Lee DH, Boniferro M, Wong CJ, Mirsen TR, Fox H. Improved recognition of leukoaraiosis and cognitive impairment in Alzheimer's disease. Arch Neurol 1991;48:1022-5
27. 27 Eikelenboom P, Stam FC. Immunoglobulins and complement factors in senile plaques. Acta Neuropathol (Berl) 1982;57:239-42
28. 28 Ekeberg O, Kjeldsen SE, Eide I, Leren P. Childhood traumas and psychosocial characteristics of 50-year-old men with essential hypertension. J Psychosom Res 1990;34:643-9
29. 29 Elias MF, Robbins MA, Schultz NR Jr, Streeten DHP, Elias PK. Clinical significance of cognitive performance by hypertensive patients. Hypertension 1987;9:192-7
30. 30 Elias MF, Robbins MA, Schultz NR Jr, Pierce TW. Is blood pressure an important variable in research on aging and neuropsychological test performance? J Gerontol 1990;45:128-35
31. 31 Elias MF, Wolf PA, D'Agostino RB, Cobb J, White LR. Untreated blood pressure level is inversely related to cognitive functioning: the Framingham Study. Am J Epidemiol 1993;138:353-64
32. 32 Englund E, Brun A. White matter changes in dementia of Alzheimer's type. The difference in vulnerability between cell compartments. Histopathology 1990;16:433-9
33. 33 Erkinjuntti T, Sulkava R. Diagnosis of multi-infarct dementia. Alzheimer Dis Assoc Disord 1991;5:112-21
34. 34 Erkinjuntti T, Hachinski V. Dementia post stroke. In: Teasell RW, ed. Physical Medicine and Rehabilitation: State of the Art Reviews Vol 7. Philadelphia: Hanley & Belfus Inc, 1993;195-212
35. 35 Erkinjuntti T, Sulkava R, Palo J, Ketonen L. White matter low attenuation on CT in Alzheimer's disease. Arch Gerontol Geriatr 1989;8:95-104
36. 36 Farmer ME, White LR, Abbott RD, Kittner SJ, Kaplan E, Wolz MM, Brody JA, Wolf PA. Blood pressure and cognitive performance. The Framingham study. Am J Epidemiol 1987;126:1103-14
37. 37 Farmer ME, Kittner SJ, Abbott RD, Wolz MM, Wolf PA, White LR. Longitudinally measured blood pressure antihypertensive medication use. and cognitive performance: the Framingham study. J Clin Epidemiol 1990;43:475-80
38. 38 Ferrer I, Bella R, Serrano M, Martí E, Guionnet N. Arteriolosclerotic leucoencephalopathy in the elderly and its relation to white matter lesions in Binswanger's disease, multi-infarct encephalopathy and Alzheimer's disease. J Neural Sci 1990;98:37-50
39. 39 Ferrucci L, Guralnik JM, Salive ME, Pahor M, Cort MC, Baroni A, Havlik RJ. Cognitive impairment and risk of stroke in the older popoulation. J Am Geriatr Soc 1996;44:237-41
40. 40 Franceschi M, Tancredi O, Smirne S, Mercinelli A, Canal N. Cognitive processes in hypertension. Hypertension 1982;4:226-9
41. 41 Fredriksson K, Brun A, Gustafson L. Pure subcortical arteriosclerotic encephalopathy (Binswanger's disease): a clinicopathologic study. Part 1 : Clinical features. Cerebrovasc Dis 1992;2:82-6
42. 42 Freidenberg DL, Van Gorp WG, Cummings JL. Subccrtical dementia. In: Katona CL, ed. Dementia Disorders. Advances and Prospects. London, New York: Chapman and Hall, 1989;104-41
43. 43 Fukuda H, Kitani M. Differences between treated and untreated hypertensive subjects in the extent of periventricular hyperintensities observed on brain MRI. Stroke 1995;26:1593-7
44. 44 Gale CR, Martyn CN, Cooper C. Cognitive impairmert and mortality in a cohort of elderly people. Br Med J 1996;12:608-11
45. 45 Ginsberg MD, Hedley-Whyte ET, Richardson EP Jr. Hypoxic-ischemic leukoencephalopathy in man. Arch Neurol 1976;33:5-14
46. 46 Glenner GG. Congophilic microangiopathy in the pathogenesis of Alzheimer's syndrome (presenile dementia). Med Hypotheses 1979;5:12316
47. 47 Goldstein G, Materson BJ, Cushman WC, Reda DJ, Freis ED, Ramirez EA, Talmers FN, White TJ, Nunn S, Chapman RH, Khatri I, Schnaper H, Thomas JR, Henderson WG, Fyc C. Treatment of hypertension in the elderly. II. Cognitive and behavioral function. Results of a Department of Veterans Affairs Cooperative Study. Hypertension 1990;15:361-9
48. 48 Goto K, Ishii N, Fukasawa H. Diffuse white-matter disease in the geriatric population. Radiology 1981;141:687-95
49. 49 Guo Z, Viitanen M, Fratiglioni L, Winblad B. Low blood pressure and dementia in elderly people: the Kungsholmen project. Br Med J 1996;312:805-8
50. 50 Gupta SR, Naheedy MH, Young JC, Ghobrial M, Rubino FA, Hindo W. Periventricular white matter changes and dementia. Clinical, neuropsychological, radiological, and pathological correlation. Arch Neurol 1988;45:637-41
51. 51 Hachinski VC. The decline and resurgence of vascular dementia. Can Med Assoc J 1990;142:107-11
52. 52 Hardy J, Mann D, Wester P, Winblad B. An integrative hypothesis concerning the pathogenesis and progression of Alzheimer's disease. Neurobiol Aging 1986;7:489-502
53. 53 Harik SI, McGunigal T. The protective influence of the locus ceruleus on the blood-brain barrier. Ann Neurol 1984;15:568-74
54. 54 Hatazawa J, Yamaguchi T, Ito M, Yamaura H, Matsuzawa T. Association of hypertension with increased atrophy of brain matter in the elderly. J Am Geriatr Soc 1984;32:370-4
55. 55 Henderson AS. The risk factors for Alzheimer's disease : a review and a hypothesis. Acta Psychiatr Scand 1988;78:257-75
56. 56 Hunt AL, Orrison WW, Yeo RA, Haaland KY, Rhyne RL, Carry PJ, Rosenberg GA. Clinical significance of MRI white matter lesions in the elderly. Neurology 1989;39:1470-4
57. 57 Ikeda T, Yamamoto K, Takahashi K, Yamada M. Immune system-associated antigens on the surface of peripheral blood lymphocytes in patients with Alzheimer's disease. Acta Psychiatr Scand 1991;83:444-8
58. 58 Janota I. Dementia, deep white matter damage and hypertension: 'Binswanger's disease'. Psychol Med 1981;11:39-48
59. 59 Johansson BB. Pathogenesis of vascular dementia: the possible role of hypertension. Dementia 1994;5:174-6
60. 60 Junqué C, Pujol J, Vendrell P, Bruna O, Jödar M, Ribas JC, Vinas J, Capdevila A, Marti-Vilalta JL. Leuko-araiosis on magnetic resonance imaging and speed of mental processing. Arch Neurol 1990;47:151-6
61. 61 Kalaria RN, Golde TE, Cohen ML, Younkin SG. Serum amyloid P in Alzheimer's disease. Implications for dysfunction of the blood-brain barrier. Ann NY Acad Sci 1991;640:145-8
62. 62 Kalra L, Jackson SHD, Swift CG. Review: Neuropsychological test performance as an indicator of silent cerebrovascular disease in elderly hypertensives. Age Ageing 1994;23:517-23
63. 63 Kertesz A, Polk M, Carr T. Cognition and white matter changes on magnetic resonance imaging in dementia. Arch Neurol 1990;47:387-91
64. 64 Kobari M, Meyer JS, Ichijo M, Oravez WT. Leukoaraiosis: correlation of MR and CT findings with blood flow, atrophy, and cognition. AJNR 1990;11:273-81
65. 65 Korczyn AD. High blood pressure and dementia. Lancet 1996;348:65
66. 66 Lantos PL, Cairns NJ. The neuropathology of Alzheimer's disease. In: Burns A, Levy R, eds. Dementia. London: Chapman and Hall, 1994
67. 67 Launer LJ, Masaki K, Petrovitch H, Foley D, Havlik RJ. The association between midlife blood pressure levels and late-life cognitive function. The Honolulu-Asia Aging Study. JAMA 1995;274:1846-51
68. 68 Licandro A, Ferla S, Tavolato B. Alzheimer's disease and senile brains: an immunofluorescence study. Riv Pat Nerv Ment 1983;104:75-87
69. 69 Light KC. Slowing of response time in young and middle aged hypertensive patients. Exp Aging Res 1975;1:209-27
70. 70 Loeb C, Gandolfo C, Croce R, Conti M. Dementia associated with lacunar infarction. Stroke 1992;23:1225-9
71. 71 Lotz PR, Ballinger WE Jr, Quisling RG. Subcortical arteriosclerotic encephalopathy: CT spectrum and pathologic correlation. AJNR 1986;7:817-22
72. 72 MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, Abbott R, Godwin J, Dyer A, Stamler J. Blood pressure, stroke, and coronary heart disease. Part I : Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet 1990;335:765-74
73. 73 Mazzucchi A, Mutti A, Poletti A, Ravanetti C, Novarini A, Parma M. Neuropsychological deficits in arterial hypertension. Acta Neurol Scand 1986;73:619-27
74. 74 McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM. Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer's disease. Neurology 1984;34:939-44
75. 75 McQuinn BA, O'Leary DH. White matter lucencies on computed tomography, subacute arteriosclerotic encephalopathy (Binswanger's disease), and blood pressure. Stroke 1987;18:900-5
76. 76 Meaney MJ, Aitken DH, van Berkel C, Bhatnagar S, Sapolsky RM. Effect of neonatal handling on age-related impairments associated with the hippocampus. Science 1988;239:766-8
77. 77 Meyer JS, Judd BW, Tawakina T, Rogers RL, Mortel KF. Improved cognition after control of risk factor for multi-infarct dementia. JAMA 1986;256:2203-9
78. 78 Miller RE, Shapiro AP, King EH, Ginchereau EH, Hosutt JA. Effect of antihypertensive treatment on the behavioral consequences of elevated blood pressure. Hypertension 1984;6:202-8
79. 79 Nag S. Cerebral changes in chronic hypertension: combined permeability and immunohistochemical studies. Acta Neuropathol (Berl) 1984;62:178-84
80. 80 Passant U. Posture and brain function in dementia. A study with special reference to orthostatic hypotension. Thesis, University of Lund, Lund, Sweden, 1996
81. 81 Passant U, Warkentin S, Minthon L, Fäldt R, Edvinsson L. Cortical blood flow during head-up postural change in subjects with orthostatic hypotension. Clin Auton Res 1993;3:311-8
82. 82 Passant U, Warkentin S, Karlson S, Nilsson K, Edvinsson L, Gustafson L. Orthostatic hypotension in organic dementia. Relationship between blood pressure, cortical blood flow and symptoms. Clin Auton Res 1996;6:29-36
83. 83 Perlmutter LS, Myers MA, Barrón E. Vascular basement membrane components and the lesions of Alzheimer's disease: light and electron microscopic analyses. Microscopy Res Tech 1994;28:204-15
84. 84 Persson G, Skoog I. A prospective population study of psychosocial risk factors for late-onset dementia. Int J Geriatr Psychiatry 1996;11:15-22
85. 85 Plum F, Posner JB, Hain RF. Delayed neurological deterioration after anoxia. Arch Intern Med 1962;110:56-63
86. 86 Pohjasvaara T, Erkinjuntti T, Vataja R. Cognitive impairment and dementia after stroke: baseline frequency in the Helsinki Aging Memory Study (the SAM) Stroke Cohort. 7th IPA Congress, Sidney, Australia, 1995 (abstr)
87. 87 Poirier J, Davignon J, Bouthillier D, Kogan S, Bertrand P, Gauthier S. Apolipoprotein E polymorphism and Alzheimer's disease. Lancet 1993;342:697-9
88. 88 Prince M. Vascular risk factors and atherosclerosis as risk factors for cognitive decline and dementia (editorial). J Psychosomat Res 1995;39:525-30
89. 89 Prince MJ, Bird AS, Blizard RA, Mann AH. Is the cognitive function of older patients affected by antihypertensive treatment? Results from 54 months of the Medical Research Council's treatment trial of hypertension in older adults. Br Med J 1996;312:801-5
90. 90 Rao SM, Mittenberg W, Bernardin L, Haughton V, Leo GJ. Neuropsychological test findings in subjects with letikoaraiosis. Arch Neurol 1989;46:40-4
91. 91 Reis DJ. The brain and hypertension Arch Neurol 1988;45:180-3
92. 92 Rockwood K, Lindsay J, McDowell I. High blood pressure and dementia. Lancet 1996;348:65
93. 93 Román GC. Senile dementia of the Binswanger type. A vascular form of dementia in the elderly. JAMA 1987;258:1782-8
94. 94 Román GC, Tatemichi TK, Erkinjuntti T, Cummings JL, Masdeu JC, Garcia JH, Amaducci L, Orgogozo JM, Brun A, Hofman A, Moody DM, O'Brien MD, Yamaguchi T, Grafman J, Drayer BP, Bennett DA, Fisher M, Ogata J, Kokmen E, Bermejo F, Wolf PA, Gorelick PB, Bick KL, Pajeau AK, Bell MA, DeCarli C, Culebras A, Korczyn AD, Bogousslavsky J, Hartmann A, Scheinberg P. Vascular dementia: diagnostic criteria for research studies. Report of the NINDS-AIREN international workshop. Neurology 1993;43:250-60
95. 95 Salerno JA, Murphy GM, Horwitz B, DeCarli C, Haxby JV, Rapoport SI, Schapiro MB. Brain atrophy in hypertension. A volumetric magnetic resonance imaging study. Hypertension 1992;20:340-8
96. 96 Sapolsky RM, Krey LC, McEwen BS. Prolonged glucocorticoid exposure reduces hippocampal neuron number: implications for aging. J Neurosci 1986;5:1222-7
97. 97 Sapolsky R, Armanini M, Packan D, Tombaugh G. Stress and glucocorticoids in aging. Endocrinol Metabol Clin N Am 1987;16:965-80
98. 98 Saunders AM, Strittmatter WJ, Schmechel D, St George-Hyslop PH, Pericak-Vance MA, Joo SH, Rosi BL, Gusella JF, Crapper-MacLachlan DR, Alberts MJ, Hulette C, Crain B, Goldgaber D, Roses AD. Association of apolipoprotein E allele ε4 with late-onset familial and sporadic Alzheimer's disease. Neurology 1993;43:1467-72
99. 99 Scheinberg P. Dementia due to vascular disease - a multifactorial disorder. Stroke 1988;19:1291-9
100. 100 Scheltens P, Barkhof F, Valk J, Algra PR, Gerritsen van der Hoop R, Nauta J, Wolters EC. White matter lesions on Magnetic Resonance Imaging in clinically diagnosed Alzheimer's disease. Evidence for a heterogeneity. Brain 1992;115:735-48
101. 101 Scherr PA, Hebert LE, Smith LA, Evans DA. Relation of blood pressure to cognitive function in the elderly. Am J Epidemiol 1991; 134:1303-15
102. 102 Schiffrin EL, Deng LY, Larochelle P. Progressive improvement in the structure of resistance arteries of hypertensive patients after 2 years of treatment with an angiotensin I-converting enzyme inhibitor. Comparison with effects of a b-blocker. J Hypertens 1995;8:229-36
103. 103 Schmidt R, Fazekas F, Offenbacher H et al. Magnetic resonance imaging white matter lesions and cognitive impairment in hypertensive individuals. Arch Neurol 1991;48:417-20
104. 104 Schultz NR, Dineen JT, Elias MF, Pentz CA III, Wood WG. WAIS performance for different age groups of hypertensive and control subjects during the administration of a diuretic. J Gerontol 1979;34:246-53
105. 105 Shapiro AP, Miller RE, King HE, Ginchereau EH, Fitzgibbon K. Behavioral consequences of mild hypertension. Hypertension 1982;4:355-60
106. 106 Skoog I. Risk factors for vascular dementia. A review. Dementia 1994;5:137-44
107. 107 Skoog I. Blood pressure and dementia. In: Hansson L, Birkenhäger WH, eds. Handbook of Hypertension. Vol 18. Assessment of Hypertensive Organ Damage. Amsterdam: Elsevier Science BV, 1997;303-31
108. 108 Skoog I, Nilsson L, Palmertz B, Andreasson LA, Svanborg A. A population-based study of dementia in 85-year-olds. N Engl J Med 1993;328:153-8
109. 109 Skoog I, Palmertz B, Andreasson LA. The prevalence of white matter lesions on computed tomography of the brain in demented and non-demented 85-year-olds. J Geriatr Psychiatry Neurol 1994;7:169-75
110. 110 Skoog I, Berg S, Johansson B, Palmertz B, Andreasson LA. The influence of white matter lesions on neuropsychological functioning in demented and non-demented 85-year-olds. Acta Neurol Scand 1996;93:142-8
111. 111 Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson LA, Nilsson L, Persson G, Odén A, Svanborg A. A 15-year longitudinal study on blood pressure and dementia. Lancet 1996;347:1141-5
112. 112 Skoog I, Lernfelt B, Landahl S. High blood pressure and dementia. Lancet 1996;348:65-6
113. 113 Soneira CF, Scott TM. Severe cardiovascular diseasa and Alzheimer's disease: senile plaque formation in cortical areas. Clin Anat 1996;9:118-27
114. 114 Sparks DL, Hunsaker JC III, Scheff SW, Kryscio RJ, Henson JL, Markesbery WR. Cortical senile plaques in coronary artery disease, aging and Alzheimer's disease. Neurobiol Aging 1990;11:601-7
115. 115 Sparks DL, Scheff SW, Liu H, Landers TM, Coyne CM, Hunsaker JC III. Increased incidence of neurofibrillary tangles (NFT) in non-demented individuals with hypertension. J Neurol Sci 1995;131:162-9
116. 116 Starr JM, Whalley LJ. Senile hypertension and cognitive impairment: an overview. J Hypertens 1992;10(suppl 2):S31-42
117. 117 Starr JM, Whalley LJ, Inch S, Sheing PA. Blood pressure and cognitive function in healthy old people. J Am Geriatr Soc 1993;41:753-6
118. 118 Steingart A, Hachinski VC, Lau C, Fox AJ, Diaz F, Cape R, Lee D, Inzitari D, Merskey H. Cognitive and neurologic findings in subjects with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis). Arch Neurol 1987;44:32-5
119. 119 Steingart A, Hachinski VC, Lau C, Fox AJ, Fox H, Lee D, Inzitari D, Merskey H. Cognitive and neurologic findings in demented patients with diffuse white matter lucencies on computed tomographic scan (leuko-araiosis). Arch Neurol 1987;44:36-9
120. 120 Strandgaard S, Paulson OB. Cerebrovascular consequences of hypertension. Lancet 1994;344:519-21
121. 121 Sulkava R, Erkinjuntti T. Vascular dementia due to cardiac arrythmias and systemic hypotension. Acta Neurol Scand 1987;76:123-8
122. 122 Talman WT. Cardiovascular regulation and lesions of the central nervous system. Ann Neurol 1985;18:1-12
123. 123 Tatemichi TK. How acute brain fauilure becomes chronic: a view of the mechanisms of dementia related to stroke. Neurology 1990;40:1652-9
124. 124 Tatemichi TK, Foulkes MA, Mohr JP, Hewitt JR, Hier DB, Price TR, Wolf PA. Dementia in stroke survivors in the Stroke Data Bank cohort. Prevalence, incidence, risk factors, and computed tomographic findings. Stroke 1990;21:858-66
125. 125 Tatemichi TK, Desmond DW, Mayeux R, Paik M, Stern Y, Sano M, Remien RH, Williams JBW, Mohr JP, Hauser WA, Figueroa M. Dementia after stroke: baseline frequency, risks, and clinical features in a hospitalized cohort. Neurology 1992;42:1185-93
126. 126 Terry RD, Gonatas NK, Weiss M. Ultrastructural studies in Alzheimer's presenile dementia. Am J Pathol 1964;44:269-81
127. 127 Thomas T, Thomas G, McLendon C, Sutton T, Mullan M. β-amyloid-mediated vasoactivity and vascular endothelial damage. Nature 1996;380:168-71
128. 128 Tomonaga M, Yamanouchi H, Tohgi H, Kameyama M. Clinicopathologic study of progressive subcortical vascular encephalopathy (Binswanger type) in the elderly. J Am Geriatr Soc 1982;30:524-9
129. 129 Torvik A. The pathogenesis of watershed infarcts in the brain. Stroke 1984;15:221-3
130. 130 Tupler LA, Coffey CE, Logue PE, Djang WT, Fagan SM. Neuropsychological importance of subcortical white matter hyperintensity. Arch Neurol 1992;49:1248-52
131. 131 van Bockxmeer FM, Mamotte CDS. Apolipoprotein E4 homocygosity in young men with coronary heart disease. Lancet 1992;340:879-80
132. 132 van Swieten JC, Geyskes GG, Derix MA et al. Hypertension in the elderly is associated with white matter lesions and cognitive decline. Ann Neurol 1991;30:825-30
133. 133 Vitiello B, Veith RC, Molchan SE, Martinez RA, Lawlor B, Radcliffe J, Hill JL, Sunderland T. Autonomic dysfunction in patients with dementia of the Alzheimer type. Biol Psychiatry 1993;34:428-33
134. 134 Wallace RB, Lemke JH, Morris MC, Goodenberger M, Kohout F, Hinrichs JV. Relationship of free-recall memory to hypertension in the elderly. The Iowa 65+ rural health study. J Chronic Dis 1985;38:475-81
135. 135 Wallin A, Blennow K, Uhlemann C, Långström G, Gottfries CG. White matter low attenuation on computed tomography in Alzheimer's disease and vascular dementia - diagnostic and pathogenetic aspects. Acta Neurol Scand 1989;80:518-23
136. 136 Wilkie F, Eisdorfer C. Intelligence and blood presure in the aged. Science 1971;172:959-62
137. 137 Wilson PWF, Myers RH, Larson MG, Ordovas JM, Wolf PA, Schaefer EJ. Apolipoprotein E alleles, dyslipidemia, and coronary heart disease: the Framingham offspring study. JAMA 1994;272:1666-71
138. 138 Wisniewski HM, Kozlowski PB. Evidence for bloodbrain barrier changes in senile dementia of the Alzheimer type (SDAT). Ann NY Acad Sci 1982;396:119-31
139. 139 Ylikoski R, Ylikoski A, Erkinjuntti T, Sulkava R, Raininko R, Tilvis R. White matter changes in healthy elderly correlate with attention and speed of mental processing. Arch Neurol 1993;50:818-24