Therapeutic basis of glycyrrhizin on chronic hepatitis B

Antiviral Research

Volumn 30, Issue 2-3, 1996, Pages 171-177

  Sato, Hitoshi ^a   Goto, Wakana ^a,b   Yamamura, Jun Ichi ^a   Kurokawa, Masahiko ^a   Kageyama, Seiji ^a   Takahara, Terumi ^a   Watanabe, Akiharu ^a   Shiraki, Kimiyasu ^a  

^a UNIVERSITY OF TOYAMA   (Japan)

^b SANTEN PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Chronic hepatitis B; Glycyrrhizin; Hepatitis B surface antigen

Indexed keywords

GLYCYRRHETINIC ACID; GLYCYRRHETINIC ACID DERIVATIVE; GLYCYRRHIZIC ACID; HEPATITIS B SURFACE ANTIGEN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN EXPRESSION; ARTICLE; CELL CULTURE; CHRONIC HEPATITIS; CONTROLLED STUDY; DRUG BINDING; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG TISSUE LEVEL; GUINEA PIG; HEPATITIS B; INTRAVENOUS DRUG ADMINISTRATION; LIVER CELL; NONHUMAN; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ANIMALIA; CAVIA; CAVIA PORCELLUS; GLYCYRRHIZA; HEPATITIS B VIRUS; SUS SCROFA;

EID: 0029924751     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/0166-3542(96)00942-4     Document Type: Article

References (26)

1. Abe, N., Ebina, T. and Ishida, N. (1982) Interferon induction by glycyrrhizin and glycyrrhetinic acid in mice. Microbiol. Immunol. 26, 535-539.
2. Akao, T., Akao, T. and Kobashi, K. (1990) Metabolism of glycyrrhetic acid by rat liver microsomes: glycyrrhetinate dehydrogenase. Biochim. Biophys. Acta 1042, 241-246.
3. Akao, T., Akao T., Hattori, M., et al. (1991) Hydrolysis of glycyrrhizin to 18β-glycyrrhetyl monoglucuronide by lysozomal β-D-glucuronidase of animal livers. Biochem. Pharmacol. 41, 1025-1029.
4. Alexander, J.J., van der Merve, C.F., Saunders, R.M., McEligott, S.E. and Desmyter, J. (1982) A comparison between in vitro experiment with a hepatoma cell line and in vivo studies. Hepatology 2 (Suppl.), 92S-96S.
5. Baba, M. and Shigeta, S. (1987) Antiviral activity of glycyrrhizin against varicella-zoster virus in vitro. Antiviral Res. 7, 99-107.
6. Crance, J.-M., Leveque, F., Biziagos, E., van Cuyck-Grandre, H., Jouan, A. and Deloince, R. (1994) Studies on mechanism of glycyrrhizin against hepatitis A virus replication. Antiviral Res. 23, 63-76.
7. Finney, R.S.H. and Somers, G.F. (1958) The anti-inflammatory activity of glycyrrhetinic acid and derivatives. J. Pharm. Pharmcol. 10, 613-620.
8. Fujisawa, K., Watanabe, H. and Kimata, K. (1973) Therapeutic approach to chronic active hepatitis with glycyrrhizin. Asian Med. J. 23, 745-756.
9. Ishida, S., Sakiya, Y., Ichikawa, T., Taira, Z. and Awazu, S. (1990) Prediction of glycyrrhizin disposition in rat and man by a physiologically based pharmacokinetic model. Chem. Pharm. Bull. 38, 212-218.
10. Ishida, S., Sakiya, Y., Ichikawa, T. and Taira, Z. (1993) Uptake of glycyrrhizin by isolated rat hepatocytes. Biol. Pharm. Bull. 16, 293-297.
11. Ito, M., Nakashima, H., Baba, M., Pauwels, R., De Clercq, E., Shigeta, S. and Yamamoto, N. (1987) Inhibitory effect of glycyrrhizin on the in vitro infectivity and cytopathic activity of the human immunodeficiency virus [HIV(HTLV-III/LAV)]. Antiviral. Res. 7, 127-137.
12. Ito, M., Sato, A., Hirabayashi, K., Tanabe, F., Shigeta, S., Baba, M., De Clercq, E., Nakashima, H. and Yamamoto, N. (1988) Mechanism of inhibitory effect of glycyrrhizin on replication of human immunodeficiency virus (HIV). Antiviral Res. 10, 289-298.
13. Kanaoka, M., Yano, S., Kato, H., Nakano, N. and Kinoshita, E. (1983) Studies on the enzyme immunoassay of bio-active constituents contained in oriental medicinal drugs. II.1) Enzyme immunoassay of glycyrrhizin. Chem. Pharm. Bull. 31, 1866-1873.
14. Kimura, M., Watanabe, H. and Abo, T. (1992) Selective activation of extrathymic T cells in the liver by glycyrrhizin. Biotherapy 5, 167-176.
15. Kitagawa, I., Hori, K., Sakagami, M., Zhou, J.-L. and Yoshikawa, M. (1993a) Saponin and sapogenol. XLVIII.1) On the constituents of the roots of glycyrrhiza uralensis FISCHER from northeastern China. (2). Licorice-saponins D3, E2, F3, G2, H2, J2, and K2. Chem. Pharm. Bull. 41, 1337-1345.
16. Kitagawa, I., Hori, K., Sakagami, M., Hashiuchi, F., Yoshikawa, M. and Ren, J. (1993b) Saponin and sapogenol. XLIX.1) On the constituents of the roots of glycyrrhiza inflata BATALIN from Xinjiang, China. Characterization of two sweet oleanane-type triterpene oligoglycosides, apioglycyrrhizin and araboglycyrrhizin. Chem. Pharm. Bull. 41, 1350-1357.
17. Nose, M., Ito, M., Kamimura, K., Shimizu, M. and Ogihara, Y. (1994) A comparison of the antihepatotoxic activity between glycyrrhizin and glycyrrhetinic acid. Planta Med. 60, 136-139.
18. Okimatsu, E., Shiraishi, N., Watanabe, S., Morimoto, Y. and Utsumi, K. (1982) Inhibitory effect of glycyrrhizin on the phospholipase A2 activity. Igaku no Ayumi 122, 174-177.
19. Pompei, R., Flore, O., Marccialis, M.A., Pani, A. and Loddo, B. (1979) Glycyrrhizic acid inhibits virus growth and inactivates virus particles. Nature (London) 281, 689-690.
20. Shinada, M., Azuma, M., Kawai, H., et al. (1986) Enhancement of interferon-γ production in glycyrrhizin-treated human peripheral lymphocytes in response to concanavalin A and to surface antigen of hepatitis B virus. Proc. Soc. Exp. Biol. Med. 181, 205-210.
21. Shiraki, K., Hayakawa, Y., Mori, H., et al. (1991) Development of immunogenic recombinant Oka varicella vaccine expressing hepatitis B virus surface antigen. J. Gen. Virol. 72, 1393-1399.
22. Shiraki, K., Ochiai, H., Matsui, S., et al. (1992) Processing of hepatitis B virus surface antigen expressed by Oka varicella vaccine virus. J. Gen. Virol. 73, 1401-1407.
23. Suzuki, H., Ohta, Y., Takino, T., Fujisawa, K. and Hirayama, C. (1983) Effects of glycyrrhizin on biological tests in patients with chronic hepatitis. A double-blind trial. Asian Med. J. 26, 423-438.
24. Takahara, T., Watanabe, A. and Shiraki, K. (1994) Effects of glycyrrhizin on hepatitis B surface antigen: a biochemical and morphological study. J. Hepatol. 21, 601-609.
25. Zhang, Y.-H., Yoshida, T., Isobe, K., Rahman, S.M.J., Nagase, F., Ding, L. and Nakashima, I. (1990) Modulation by glycyrrhizin of the cell-surface expression of H-2 class I antigens on murine tumor cell lines and normal cell populations. Immunology 70, 405-410.
26. Zhang, Y.-H., Isobe, K., Iwamoto, T. and Nakashima, I. (1992) Bidirectional control by glycyrrhizin of the growth response of lymphocytes stimulated through a receptor-by-passed pathway. Immunol. Lett. 32, 147-152.